Skin cancer is the most common type of cancer in the U.S. It occurs in more than a million people each year, including many older people. There are three main types of skin cancer: basal cell carcinoma, squamous cell carcinoma, and melanoma. Of the three, melanoma is the most serious. Skin cancer occurs when abnormal cells form and multiply in an uncontrolled way in the epidermis, or abnormal cells from the epidermis invade the dermis of the skin. Basal cell carcinoma, squamous cell carcinoma, and melanoma are skin cancers that are named for the epidermal cells from which they develop.
Tumors have developed many strategies and tricks to gain advantages in the body. Led by cell biology professor Sabine Werner, researchers at ETH Zurich have now discovered another surprising trick that certain tumors resort to in ensuring their survival and growth.
Weill Cornell Medicine researchers have discovered that PD-1—a molecule best known for putting the brakes on immune cells—also plays a critical role in helping T cells become long-term immune defenders in the skin.
The skin microbiome plays an important role in health and disease. Researchers have now substantiated that certain skin bacteria can protect us from the sun's ultraviolet (UV) radiation specifically by metabolizing cis-urocanic acid using an enzyme called urocanase.
Over the past 15 years, developments in the gene-editing technique known as CRISPR-Cas9 have produced significant new understandings of the functions that particular genes play in a variety of disorders.
Ultraviolet (UV) radiation from the sun is a well-known cause of DNA damage, which can lead to diseases like skin cancer.
LMU researchers have discovered how the interplay between a key protein and an endolysosomal ion channel promotes tumor development in skin cancer.
Researchers utilized specialized genomic technology at the University of Calgary to enhance our understanding of Marjolin's ulcer (MU), a rare, highly aggressive skin cancer that affects chronic wounds that can often arise from established scars like those caused by severe burns.
Scientists from the Texas A&M College of Veterinary Medicine and Biomedical Sciences (VMBS) and Uppsala University in Sweden now understand why some gray horses turn completely white as they age, while others remain an eye-catching "dappled" gray color.
AMLo Biosciences Ltd (Newcastle upon Tyne, UK) announces the successful receipt of the UKCA mark for AMBLor. AMBLor is a groundbreaking histopathological biomarker test for the personal identification of early-stage melanomas at low risk of progression, post staging diagnosis.
An extensive family of proteins that gives human skin mechanical strength also appears to organize molecular signals that control skin cell activity, a study led by UT Southwestern Medical Center researchers shows.
An international research team has discovered a new way to effectively treat cancer, by using nutrients to reactivate suppressed metabolic pathways in cancer cells.
The way the protein XPD recognizes severe DNA damage and regulates its repair was uncovered by researchers at the University of Würzburg, under the direction of Caroline Kisker and Claudia Höbartner.
Most people associate skin cancer warnings with sunburn and tanning beds. “Cancer genes” or inherited risks are associated with diseases such as breast and colon cancer.
Melanoma is the deadliest form of skin cancer. With global incidence rates rising, new, more effective treatments are necessary to alleviate the health burden of the disease. Important advances in recent years include doctors using genetic tests to look for specific mutations they can target for more personalised, effective treatment.
Researchers have unveiled groundbreaking insights into CD4+ T cells, a kind of immune cell, demonstrating the potential for immunotherapies targeting melanoma, the most fatal kind of skin cancer.
Scientists have, for the first time, demonstrated the presence of hemoglobin—a protein primarily known for its role in binding with oxygen within red blood cells—in the epidermis, the outermost tissue layer of human skin.
University of Rochester scientists have successfully transmitted a longevity gene from naked mole rats to mice, resulting in better health and an extension of the mouse’s lifespan.
Tumors are not just isolated clumps of abnormal cells but are associated with more complex system known as the "tumor microenvironment" (TME).
Even as pancreatic cancer treatments advance, only around 9% of patients live beyond five years. Scientists have failed to identify genetic distinctions that explain why some patients live for a long time and others do not, so they have moved their emphasis to the gut microbiome.
Aging, or senescent cells, which stop dividing but don't die, can accumulate in the body over the years and fuel chronic inflammation that contributes to conditions such as cancer and degenerative disorders.
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