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New and unconventional nuclear function for oncogenic microRNA discovered

microRNAs (miRNA), non-coding RNA molecules, are widely known for regulating mRNA stability and translation. miR-10b has been increasingly implicated in the pathogenesis of gliomas, cancers of the brain.

16 Feb 2022

Noramco Announces Submission of Drug Master File for Lisdexamfetamine Dimesylate ─ Active Pharmaceutical Ingredient

Leading Producer of Controlled Substance APIs Now Supplying Lisdex API to Generic Drug Manufacturers Preparing for the 2023 Patent Expiry of Top-Selling Branded ADHD Therapy

3 Dec 2021

Persistency allows value signals to be most effectively coded across different brain areas

In 2019 University of California San Diego researchers discovered the area of the brain where "value decisions" are made.

24 Nov 2021

Study proposes a novel approach for developing safer analgesics

Opioids are potent painkillers; however, their use is hampered as patients become tolerant to them, necessitating more and more doses.

From The University of California, Davis 31 Aug 2021

Massive study identifies 579 genomic locations linked to self-regulating behaviors

Researchers have identified 579 locations in the human genome associated with a predisposition to self-regulation-related behaviors, including addiction and child behavioral problems. With data from 1.5 million people of European descent, the effort is considered to be one of the largest genome-wide association studies to date.

27 Aug 2021

Old habit-controlling neurons may also play a key role in learning new tricks

Imagine working on your computer and typing the same long password you have used for years to access your email.

26 Aug 2021

Study identifies variants and genes linked to alcohol consumption

Scientists from the Icahn School of Medicine at Mount Sinai published the first of its kind research in the field of addiction genetics employing a multi-omics method to offer a huge list of causal candidate genes linked with alcohol consumption and alcohol use disorder (AUD).

24 Aug 2021

Study analyzes the neuronal mechanism of fruit flies in decision making

According to scientists, people tend to prioritize food over sex after being deprived of both. The researchers examined this behavioral conflict in fruit flies.

10 Aug 2021

Study unravels genetic markers involved in life’s momentous milestones

A team of Oxford researchers successfully identified hundreds of genetic markers that are involved in two of life’s most momentous milestones.

5 Jul 2021

Developing a portable tool to detect street drug ‘spice’

AZoLifeSciences speaks to researchers from the University of Bath about their latest research that led to the development of a device that can detect 'spice'.

From University of Bath 28 Apr 2021

Unique mini-microscope enables imaging of brain activity in freely moving mice

Researchers from the University of Minnesota Twin Cities College of Science and Engineering and Medical School have developed a unique head-mounted mini-microscope device that allows them to image complex brain functions of freely moving mice in real time over a period of more than 300 days.

6 Apr 2021

Many light smokers meet the criteria for nicotine addiction

Even people who consider themselves to be casual cigarette smokers may be addicted, according to current diagnostic criteria. Researchers at Penn State College of Medicine and Duke University found that many light smokers -- those who smoke one to four cigarettes per day or fewer -- meet the criteria for nicotine addiction and should therefore be considered for treatment.

24 Dec 2020

Researchers describe how drug use change specific brain cells responsible for motivation

In the October 28, 2020 issue of the Journal of Neuroscience, researchers from the Medical University of South Carolina and the National Institutes of Health describe how reminders of drug use can change specific brain cells responsible for motivation, increasing the desire to seek drugs.

30 Oct 2020

Study shows cocaine use in mice leads to formation of synapses

Drugs of abuse, like cocaine, are so addictive due in part to their cellular interaction, creating strong cellular memories in the brain that promote compulsive behaviors.

16 Oct 2020

Cocaine addiction: Impact of genetic mutations elucidated

Cocaine addiction is a chronic disorder with a high rate of relapse for which no effective treatment is currently available.

28 Sep 2020

Long-term opioid use in back-pain patients leads to production of anti-opioid antibodies

University of Wisconsin-Madison scientists have discovered that a majority of back-pain patients they tested who were taking opioid painkillers produced anti-opioid antibodies.

19 Aug 2020

West Virginia University performs revolutionary Alzheimer's treatment

A hospital nurse for 33 years, Nanette Miller would call her husband Frank at the end of each shift to let him know she was coming home.

10 Aug 2020

Substances that target oxytocin receptors can help treat various diseases

Oxytocin is the so-called “cuddle hormone” or “love hormone” that plays a role in strengthening the relationship between the mother and child and controlling social bonding.

17 Jul 2020

UVA scientists identify oncogene responsible for glioblastoma

Scientists have identified an oncogene (a cancer-causing gene) responsible for glioblastoma, the deadliest brain tumor.

15 Jul 2020

Less addictive opioid may have the ability to slow progression of osteoarthritis

A novel preclinical study by Keck Medicine of USC researchers, published in Arthritis & Rheumatology, reveals that a potential new opioid medication may have the ability to slow the progression of osteoarthritis while being less addictive than commonly prescribed opioid drugs.

14 Jul 2020