Antiretroviral News and Research

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Latest CRISPR-Cas Gene Editing Can Eliminate All Traces of HIV Virus From Infected Cells

New research presented early ahead of this year's European Congress of Clinical Microbiology and Infectious Diseases (ECCMID 2024, Barcelona, 27-30 April) from a team of researchers in the Netherlands shows how the latest CRISPR-Cas gene editing technology can be used to eliminate all traces of the HIV virus from infected cells in the laboratory, raising hopes of a cure.

20 Mar 2024

Drug Candidates Show Promise to Reverse HIV's Ability to Escape Immune System Detection

University of Pittsburgh School of Medicine scientists have identified drug candidates that show promise to reverse the ability of HIV to escape detection by the immune system.

20 Mar 2024

Study Sheds Light on Factors Contributing to Low-Level Viremia in HIV Patients

Human immunodeficiency virus (HIV) works by entering specific immune cells and replicating inside them.

15 Nov 2023

Age-Related Hearing Loss Associated With Decrease of Cholesterol in the Inner Ear

Researchers led by María Eugenia Gomez-Casati, the Institute of Pharmacology, School of Medicine, University of Buenos Aires-CONICET; Mauricio Martin, the Institute of Medical Research Mercedes; and Martín Ferreyra, (INIMEC-CONICET-UNC), National University of Córdoba in Argentina report that age-related hearing loss is associated with a decrease of cholesterol in the inner ear.

25 Aug 2023

Microglial Cells Serve as a Stable Viral Reservoir for Latent HIV

Human immunodeficiency virus-1 (HIV) introduces a copy of its DNA into human immune cells as part of its life cycle. Some of these newly infected immune cells can subsequently enter an inactive, latent state for an extended length of time, which is known as HIV latency.

19 Jun 2023

Identifying Drugs to Put the Brakes On Accelerated Aging From HIV Infection, Treatment

Antiretroviral cocktails can make human immunodeficiency virus, or HIV, undetectable and untransmittable, but both the virus and its treatment can also accelerate aging of bone and muscle.

24 May 2023

The Pivotal Role of Combinatorial CRISPR Gene Editing in the Elimination of HIV-1 Infection

Recent research from Temple University’s Lewis Katz School of Medicine and the University of Nebraska Medical Center demonstrates that gene-editing therapy aimed at two targets - HIV-1, the virus that causes AIDS, and CCR5, the co-receptor that aids the virus getting into cells—can effectively eliminate HIV infection.

2 May 2023

Novel inhibitor, hopeaphenol, blocks HIV expression

In the United States, around 1.2 million people are living with HIV as of 2022. Many of these people can now live productive, symptom-free lives thanks to antiretroviral therapies, but a solution that permanently removes HIV from an infected person’s body is still a long way off.

30 Mar 2023

Myeloid cells contribute to a long-lived HIV reservoir, study shows

A subset of white blood cells, known as myeloid cells, can harbor HIV in people who have been virally suppressed for years on antiretroviral therapy, according to findings from a small study supported by the National Institutes of Health.

28 Mar 2023

Monocytes harbor stable HIV DNA capable of infecting neighboring cells

To develop treatments that may one day entirely rid the body of HIV infection, scientists have long sought to identify all of the places that the virus can hide its genetic code.

28 Mar 2023

Psychological trauma related to HIV could make it difficult to end the AIDS epidemic

Failing to address the psychological trauma experienced by many older people living with HIV/AIDS will make it difficult, if not impossible, to end the epidemic, according to a Rutgers study.

8 Feb 2023

HIV’s covert methods of evading treatment and immunity

According to Duke Health researchers, the human immunodeficiency virus (HIV) appears to be driven into a latent state, lurking in cells only to erupt once more. This immune response likely evolved to help fight infections.

15 Nov 2022

HIV latent cells produce a possible cure investigation

Researchers from the National Institute of Allergy and Infectious Diseases (NIAID) Vaccine Research Center (VRC) and their collaborators gave a presentation recently at AIDS 2022, the 24th International AIDS Conference in Montreal.

1 Aug 2022

Study finds broadly neutralizing antibodies might help to treat or cure HIV infection

According to research, carefully formulated combinations of broadly neutralizing antibodies might effectively cure HIV while reducing the chance that the virus would evade therapy.

22 Jul 2022

Study reveals why infected individuals cannot get rid of HIV altogether

Thanks to antiretroviral therapy, HIV infection is no longer the life sentence it once was. But despite the effectiveness of drugs to manage and treat the virus, it can never be fully eliminated from the human body, lingering in some cells deep in different human tissues where it goes unnoticed by the immune system.

28 Mar 2022

Antiretroviral News and Research

Latest CRISPR-Cas Gene Editing Can Eliminate All Traces of HIV Virus From Infected Cells

Drug Candidates Show Promise to Reverse HIV's Ability to Escape Immune System Detection

Study Sheds Light on Factors Contributing to Low-Level Viremia in HIV Patients

Age-Related Hearing Loss Associated With Decrease of Cholesterol in the Inner Ear

Microglial Cells Serve as a Stable Viral Reservoir for Latent HIV

Identifying Drugs to Put the Brakes On Accelerated Aging From HIV Infection, Treatment

The Pivotal Role of Combinatorial CRISPR Gene Editing in the Elimination of HIV-1 Infection

Novel inhibitor, hopeaphenol, blocks HIV expression

Myeloid cells contribute to a long-lived HIV reservoir, study shows

Monocytes harbor stable HIV DNA capable of infecting neighboring cells

Psychological trauma related to HIV could make it difficult to end the AIDS epidemic

HIV’s covert methods of evading treatment and immunity

HIV latent cells produce a possible cure investigation

Study finds broadly neutralizing antibodies might help to treat or cure HIV infection

Study reveals why infected individuals cannot get rid of HIV altogether

VOYAGER adjustable tip spacing pipette increases productivity in a real-life situation

INTEGRA’s VOYAGER helps HIV researchers get more results in significantly less time

Metabolic restoration could provide natural protection against HIV

New approach to identify molecular targets for improved prostate cancer therapy

Study may help develop multi-pronged HIV eradication strategies

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