Autoimmune Disease is a condition in which the body recognizes its own tissues as foreign and directs an immune response against them.
Immune cells must learn not to attack the body itself. A team of researchers from the Technical University of Munich (TUM) and the Ludwig Maximilian University of Munich (LMU) has discovered a previously unknown mechanism behind this: other immune cells, the B cells, contribute to the "training" of the T cells in the thymus gland.
Bacteria have an immune system that protects them against viruses known as bacteriophages. A research team from the Universities of Tübingen and Würzburg has now shown how this immune system enhances the effect of specific antibiotics against the cholera pathogen Vibrio cholerae.
An autoimmune disease occurs when the body’s own cells are attacked by the immune system in addition to external pathogens.
Martin Taylor, MD, PhD, a physician investigator in the Department of Pathology at Massachusetts General Hospital and an instructor in Pathology at Harvard Medical School, is the lead corresponding author of a new study in Nature, Structural Analysis and Inhibition of Human LINE-1 ORF2 Protein Reveals Novel Adaptations and Functions.
In a study of historic scale, scientists at Gladstone Institutes have created an intricate map of how the immune system functions, examining the detailed molecular structures governing human T cells using the next-generation CRISPR tool known as base editing.
Scientists at La Jolla Institute for Immunology (LJI) are investigating a talented type of T cell.
We speak to Dr. Ruth Kroschewski about new research that details the existence of an 'exclusome', a cytoplasmic container that appears to explain where extra-chromosomal DNA goes once it is in a cell.
But the condition is less common in men, even though they are more likely to have the 4 genetic variations implicated in heightened risk, suggesting that there may be sex specific causes, say the researchers.
Platelets, or thrombocytes, are specialized cellular fragments that form blood clots when we get scrapes and traumatic injuries. Viral infections, autoimmune disease, and other conditions can cause platelet levels to drop throughout the body, termed thrombocytopenia.
Scripps Researchers have found that looking at a certain type of immune cell in the blood can help pinpoint those who are most vulnerable to acquiring type 1 diabetes, a fatal autoimmune disease
N6-methyladenosine (m6A) is the most extensively studied RNA modification across multiple species, and its importance in the immune system has been demonstrated in a variety of contexts, including mRNA metabolism, cell differentiation, proliferation, and response to stimulation.
Research of over 22,000 patients with multiple sclerosis (MS) has for the first time discovered a genetic variant linked with speedier progression of the disease, a buildup of disability that can deprive patients of their mobility and independence over time.
A gene expression signature that has the potential to forecast the advance of type 1 diabetes has been determined by scientists from Turku Bioscience Centre and InFLAMES Flagship at the University of Turku in Finland.
Throughout the world, IgA deficiency is considered to be the most common primary immune deficiency, but its presentation has continued to confuse researchers and physicians.
A breakthrough in gene variants of an inflammation “brake” brings researchers one step closer to developing personalized treatments for those at risk of kidney disease and kidney failure.
The University of Hong Kong (HKU) School of Biological Sciences research team led by Dr. Gary Ying Wai Chan has uncovered the function of a unique enzyme called ANKLE1.
According to a recent study headed by the Children’s Hospital of Philadelphia (CHOP), a regulatory class of human T cells is descended from two distinct origins, one related to autoimmunity and one related to protective immunity.
Scientists at the Francis Crick Institute have found that high consumption of a common artificial sweetener, sucralose, lowers activation of T-cells, an important component of the immune system, in mice.
The biological function of the C-reactive protein, CRP, has long been unidentified. Investigators at LiU have discovered that this protein has a useful function in the inflammatory disease systemic lupus erythematosus or SLE.
The biological function of the C-reactive protein, CRP, has long been unknown. Researchers at Linköping University in Sweden now show that this protein has a beneficial function in systemic lupus erythematosus, SLE, an inflammatory disease.