Biomarker News and Research

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A biomarker is a biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule.

Computational DNA droplet recognizes a specific combination of tumor biomarker microRNAs

The formation of aqueous droplets in macromolecules by liquid-liquid phase separation (or coacervation) is a popular topic in life sciences research. DNA is particularly interesting among the numerous macromolecules that form droplets because it is predictable and programmable, both of which are desirable properties in nanotechnology.

6 Jun 2022

Researchers conduct a comprehensive survey of the aging epigenome across the chromatin hierarchy

Highly structured chromatin encodes the program of life with only one set of genes in the core of every cell. Since various genes are stimulated at different periods of life while staying silent elsewhere, this is feasible. Some genes from a former life stage are hidden deep within the nuclear perimeter, while others manage to break out.

1 Jun 2022

Researchers devise a new treatment approach to cure aggressive brain tumors

Glioblastomas (GBMs) are cancerous tumors of the brain and spinal cord that are incredibly aggressive.

23 May 2022

Cancer biomarkers relying on methylation could forecast tumor type

In cancer management, biomarkers are commonly used to guide treatment decisions and evaluate patient outcomes.

23 May 2022

Study underscores the crucial role of genomic profiling in diagnosing and grading brain tumors

Patients diagnosed with a type of brain tumor survived for longer when they were treated aggressively with surgery, radiation and chemotherapy.

22 Apr 2022

Research reveals how RNA elements control cleavage activity of DICER enzyme in pre-miRNA and shRNAs

A research team led by scientists from the Hong Kong University of Science and Technology has revealed how secondary structure RNA elements control the cleavage activity of the DICER enzyme in both pre-miRNA and short-hairpin RNAs, improving the understanding of the DICER cleavage mechanism and providing a foundation for the design of accurate and efficient short-hairpin RNAs for gene-silencing.

20 Apr 2022

Spatial maps offer insights into the battle between melanoma cells and immune cells

Melanoma is a somewhat unusual cancer-;one that blooms before our very eyes, often on sun-exposed skin, and can quickly become deadly as it turns our own skin against us and spreads to other organs.

From Harvard Medical School 15 Apr 2022

Biologists unravel the mystery behind nuclear anomaly in blood cancer cells

The mystery is being unraveled of why the control centers, or nuclei, of certain blood cancer cells have a distinctly odd shape.

5 Apr 2022

Proteins in saliva could serve as a biomarker to identify patients at risk for severe COVID-19

Researchers have identified a family of proteins that is significantly elevated in the saliva of patients hospitalized with COVID-19.

5 Apr 2022

Researchers identify new set of protein biomarkers for cancer using breast milk

A simple blood test for women of all ages and risk levels could one day be possible thanks to a new set of protein biomarkers that researchers identified using breast milk.

5 Apr 2022

Researchers discover abnormal gene mutations that lead to cancer development

The reason why the control centers, or nuclei, of certain blood cancer cells, have a peculiar structure is still a mystery.

1 Apr 2022

Specific gene variant linked with poor response to sublingual immunotherapy for allergies

Although sublingual immunotherapy (SLIT) has become an effective treatment option for many allergies, about 20-30% of patients don’t respond to SLIT for Japanese cedar pollinosis–a highly common disease.

8 Mar 2022

Two distinct classes of stem cells drive treatment resistance in patients with myelodysplastic syndromes

Researchers from The University of Texas MD Anderson Cancer Center discovered that treatment resistance in patients with myelodysplastic syndromes (MDS) is caused by two distinct classes of stem cells and identified possible therapeutic approaches that target these cells.

3 Mar 2022

Researchers discover how pancreatic cells remodel themselves to reduce the immune response in patients at risk for T1D

Scientists have observed for the very first time that insulin-producing cells in the pancreas are attacked by T lymphocytes during the evolution of Type 1 Diabetes.

2 Mar 2022

Researchers study how metabolomic assessment finds postmortem biomarkers indicating decedent’s diabetes mellitus history

One of the most important and difficult aspects of a forensic examination is identifying the cause of death.

2 Mar 2022

Newly developed radio-labeled molecule may be able to pinpoint areas of inflammation

Researchers at The University of Texas MD Anderson Cancer Center have developed a new radio-labeled molecule capable of selectively reacting with certain high-energy radicals that are characteristic of innate immune activity, which may allow a non-invasive approach to monitor inflammation in real time by positron emission tomography (PET) imaging.

22 Feb 2022

CNIO researchers design new platform to test drugs for possible use in brain metastases

It is estimated that about a quarter of cancer patients are at risk of brain metastases, a rate that is increasing especially among those who suffer relapses after having undergone different cancer treatments.

18 Feb 2022

Illumina partners with centers across France to advance a precision medicine approach for patients with late-stage cancer

Joint study will assess clinical value of comprehensive genomic profiling (CGP) on cancer therapy options in patients with advanced disease

17 Feb 2022

Clemson University research focuses on identifying networks of genes involved in uterine cancer

No single gene causes uterine cancer, the fourth most common cancer among women, which is on the rise in the U.S.

31 Jan 2022

Diet induces permanent genetic alterations in the gut microbes, study reveals

A recent study found that diet can influence the evolutionary path of bacteria in the gut within host-relevant timescales.

31 Jan 2022

Biomarker News and Research

Computational DNA droplet recognizes a specific combination of tumor biomarker microRNAs

Researchers conduct a comprehensive survey of the aging epigenome across the chromatin hierarchy

Researchers devise a new treatment approach to cure aggressive brain tumors

Cancer biomarkers relying on methylation could forecast tumor type

Study underscores the crucial role of genomic profiling in diagnosing and grading brain tumors

Research reveals how RNA elements control cleavage activity of DICER enzyme in pre-miRNA and shRNAs

Spatial maps offer insights into the battle between melanoma cells and immune cells

Biologists unravel the mystery behind nuclear anomaly in blood cancer cells

Proteins in saliva could serve as a biomarker to identify patients at risk for severe COVID-19

Researchers identify new set of protein biomarkers for cancer using breast milk

Researchers discover abnormal gene mutations that lead to cancer development

Specific gene variant linked with poor response to sublingual immunotherapy for allergies

Two distinct classes of stem cells drive treatment resistance in patients with myelodysplastic syndromes

Researchers discover how pancreatic cells remodel themselves to reduce the immune response in patients at risk for T1D

Researchers study how metabolomic assessment finds postmortem biomarkers indicating decedent’s diabetes mellitus history

Newly developed radio-labeled molecule may be able to pinpoint areas of inflammation

CNIO researchers design new platform to test drugs for possible use in brain metastases

Illumina partners with centers across France to advance a precision medicine approach for patients with late-stage cancer

Clemson University research focuses on identifying networks of genes involved in uterine cancer

Diet induces permanent genetic alterations in the gut microbes, study reveals

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