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New Approach to Constructing Human Artificial Chromosomes Avoids Unintended Multimerization

New Approach to Constructing Human Artificial Chromosomes Avoids Unintended Multimerization

Constructing human artificial chromosomes (HACs) in budding yeast overcomes the long-standing problem of uncontrolled multimerization – the rampant joining of similar molecules – and results in HACs that are large, stable, and structurally well-defined, researchers report.

22 Mar 2024

New Insights Into How Genes Are Activated

New Insights Into How Genes Are Activated

Genetic information contained within DNA has to be read by specific proteins that enable the process of gene activation to begin – but in many cases, these proteins can't access their targets because DNA strands are bundled up to control what genes are used in the wide range of different cell types.

12 Jul 2023

New insights into the distribution and regulation of meiotic DSB hotspots

New insights into the distribution and regulation of meiotic DSB hotspots

A new method, DNA End tailing and sequencing (DEtail-seq), for meiotic DNA double-strand break (DSB) profiling was developed recently.

3 Mar 2023

Researchers show how the production of different macromolecules peaks at different times

Researchers show how the production of different macromolecules peaks at different times

Textbooks will tell you that in dividing cells, the production of new DNA peaks during the S-phase, while production of other macromolecules, such as proteins, lipids, and polysaccharides, continues at more or less the same level.

28 Feb 2023

Novel insights into the elongation dynamics of eukaryotic cells

Novel insights into the elongation dynamics of eukaryotic cells

The proper functioning of numerous proteins generated in cells by ribosomes is essential for life. This diversified variety of proteins, called proteome, is sustained by the ribosomes’ vigorous translation elongation of amino acid sequences.

6 Jan 2023

Scientists discover that most synonymous mutations are strongly harmful

Scientists discover that most synonymous mutations are strongly harmful

University of Michigan scientists reveal that most synonymous mutations are severely damaging in a study published in Nature that entailed genetic manipulation of yeast cells in the lab.

9 Jun 2022

AMN1: New gene target for antifungal therapy against cluster-forming pathogenic fungus

AMN1: New gene target for antifungal therapy against cluster-forming pathogenic fungus

A recent study indicates that regulating and deleting a particular gene (AMN1) in yeast might lay the groundwork for a novel method of addressing drug resistance in microbial infections and cancer.

18 Apr 2022

High-resolution map of yeast genome can shed light on development responses in higher organisms

High-resolution map of yeast genome can shed light on development responses in higher organisms

A new study explains an effort to create the most detailed and high-resolution map of gene regulation and chromosome architecture in yeast organisms.

15 Mar 2021

New insights into recombination of sex chromosomes during meiosis

New insights into recombination of sex chromosomes during meiosis

As chromosomes go, X and Y make an unlikely pair. The X is large and contains thousands of genes critical for life.

29 May 2020

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