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In the late 1980s and mid-1990s, genomes of diverse lineages of bacteria and archaea (the latter representing a domain of single-celled prokaryotic microorganisms) revealed clusters of regularly interspaced short palindromic repeats, known today under the abbreviation CRISPR. Later it was found that these repeat sequences (previously considered disparate) share a common set of features.

Study clears potential obstacle to using gene drive strategy to control mosquitoes

New research from entomologists at UC Davis clears a potential obstacle to using CRISPR-Cas9 "gene drive" technology to control mosquito-borne diseases such as malaria, dengue fever, yellow fever and Zika.

From The University of California, Davis 17 Apr 2020

Diagnostics, Meet CRISPR

The simplicity of urine sampling has been combined with the excellent sensing abilities of CRISPR to improve diagnostic testing for kidney transplant patients.

17 Apr 2020

How human cells recognize undesirable guests

Until now, the immune sensor TLR8 has remained in the shadows of science. A research team led by the University of Bonn has now discovered how this sensor plays an important role in defending human cells against intruders.

15 Apr 2020

New genetic techniques expand microbial research

A team of international scientists has developed a suite of more than 200 new genetic techniques for using marine microbes to investigate a host of questions in biology.

7 Apr 2020

Study examines molecular causes of spondylocostal dysostosis

Researchers from EMBL Barcelona’s Ebisuya group collaborated with colleagues from RIKEN, Kyoto University, and Meijo Hospital in Nagoya, Japan, to investigate oscillating patterns of gene expression, coordinated across time and space within a tissue grown in vitro.

7 Apr 2020

Primitive bacterial parasites were first to use CRISPR to combat against one another

Humans are not the first to leverage the benefits of CRISPR. Pioneering research at the University of Copenhagen (UCPH) has enabled redefining what CRISPR is.

25 Mar 2020

New CRISPR technology targets thousands of genes

Thanks to CRISPR-based genetic screens, researchers were able to detect genes that play a major role in lung cancer metastasis, cancer immunotherapy, sickle-cell anemia, and a host of other medical disorders.

18 Mar 2020

Study explains “dark” portion of human genome implicated in various disorders

A “dark” part of the human genome has puzzled researchers for many years, similar to an enigmatic dark matter that accounts for 85% of the universe.

12 Mar 2020

Study reports first-ever application of CRISPR-Cas12b system in plant genome engineering

In a study reported recently in Nature Plants, Yiping Qi—assistant professor of Plant Science at the University of Maryland—has found a new CRISPR genome engineering system, called CRISPR-Cas12b, that is viable in plants for the first time.

10 Mar 2020

Study explores the impact of solute carriers on the activity and potency of cytotoxic drugs

At the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, scientists have investigated how solute carriers (SLCs)—a large class of membrane transport proteins—affect the activity and potency of cytotoxic drugs, for example, those used to treat leukemia and other cancers.

10 Mar 2020