CRISPR News and Research

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In the late 1980s and mid-1990s, genomes of diverse lineages of bacteria and archaea (the latter representing a domain of single-celled prokaryotic microorganisms) revealed clusters of regularly interspaced short palindromic repeats, known today under the abbreviation CRISPR. Later it was found that these repeat sequences (previously considered disparate) share a common set of features.

New Gene Editing Technique Reduces Chalkiness in Rice

As global temperatures continue to rise, maintaining the quality and yield of crops adapted to lower temperatures will increasingly become a challenge.

31 Jul 2023

Study Identifies a Gene That Largely Controls Weeping Growth in Apple

Plant geneticists have identified a mutation in a gene that causes the "weeping" architecture – branches growing downwards – in apple trees, a finding that could improve orchard fruit production.

21 Jul 2023

The Function of Stem Cell Barriers in the Treatment of Fertility

A set of molecules controls cells as they proliferate and take on certain identities and spatial placements within a human embryo as it develops.

18 Jul 2023

Using CRISPR to Improve Forest Resilience and Productivity

Researchers at North Carolina State University used a CRISPR gene-editing system to breed poplar trees with reduced levels of lignin, the major barrier to sustainable production of wood fibers, while improving their wood properties.

14 Jul 2023

Gene Recognition of CRISPR-Cas Visualized With New Method

A novel technique has been devised by researchers from the University of Leipzig and the University of Vilnius in Lithuania to monitor the smallest twists and torques of molecules in milliseconds.

13 Jul 2023

Genome of Xerces Blue Butterfly Reveals Extinction Story

The Xerces Blue butterfly (Glaucopsyche xerces) was native to the coastal dunes of San Francisco, in the United States. As the city grew, much of the butterfly's habitat was destroyed and its population was relegated to Golden Gate National Park.

12 Jul 2023

New Culture System may Improve Efficiency and Safety of Genome Editing in HSCs

Hematopoietic stem cells (HSCs) are rare cells found in the bone marrow that produce red blood cells, white blood cells, and platelets.

11 Jul 2023

Researchers Develop New Way to Genetically Suppress Malaria-Carrying Mosquitoes

Malaria remains one of the world's deadliest diseases. Each year malaria infections result in hundreds of thousands of deaths, with the majority of fatalities occurring in children under five.

6 Jul 2023

Deep Learning Model Accurately Predicts RNA-Targeting CRISPR Activity

According to new research published in Nature Biotechnology, artificial intelligence can predict on- and off-target behavior of CRISPR tools that target RNA rather than DNA.

5 Jul 2023

Genetically Modified iPS Cell Applications for Fabry Disease

iPS cells have had a significant impact on biology and medicine, and they are expected to increase regenerative medicine. Clinical trials with various cell types derived from iPS cells have been performed since 2014 when a sheet of retinal pigment epithelial cells obtained from iPS cells was transplanted into patients with age-related macular degeneration.

4 Jul 2023

The First Programmable RNA-Guided System in Eukaryotes Uncovered

Feng Zhang of the Broad Institute at MIT and Harvard and the McGovern Institute for Brain Research at MIT headed a team of researchers who discovered the first programmable RNA-guided mechanism in eukaryotes, which include fungi, plants, and animals.

29 Jun 2023

Albino Squid Illuminates Cephalopod Brain Activity

A team of researchers at the Marine Biological Laboratory (MBL) has successfully engineered an albino strain of Euprymna berryi, the hummingbird bobtail squid.

21 Jun 2023

Review: Role of Alternative Splicing Defects in Major Neurodegenerative Diseases

Alternative splicing, a clever way a cell generates many different variations of messenger RNAs -; single-stranded RNAs involved in protein synthesis -; and proteins from the same stretch of DNA, plays an important role in molecular biology.

21 Jun 2023

Utilizing Genome Editing to Encourage High Crop Yields

According to a recent study released in the journal Nature on June 14th, 2023, scientists from the University of California, Davis, and an international team of researchers utilized the genome-editing tool CRISPR-Cas to generate disease-resistant rice plants.

16 Jun 2023

Dual CRISPR Gene Drive Systems Target a Specific Gene

According to recent research from North Carolina State University, scientists have created a “homing gene drive system” based on CRISPR/Cas9 that could be used to suppress populations of Drosophila suzukii vinegar flies—so-called “spotted-wing Drosophila” that severely damage soft-skinned fruit in North America, Europe, and parts of South America.

13 Jun 2023

CRISPR/Cas9 Unlocks the Key Gene in the Development of Coral Skeleton Formation

Recent research conducted by Phillip Cleves of Carnegie employs sophisticated CRISPR/Cas9 genome editing technologies to identify a gene essential to stony corals’ capacity to construct complex reef designs. Proceedings of the National Academy of Sciences published this.

6 Jun 2023