CRISPR News and Research

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In the late 1980s and mid-1990s, genomes of diverse lineages of bacteria and archaea (the latter representing a domain of single-celled prokaryotic microorganisms) revealed clusters of regularly interspaced short palindromic repeats, known today under the abbreviation CRISPR. Later it was found that these repeat sequences (previously considered disparate) share a common set of features.

New Class of CRISPR-Cas Enzymes for Precise Genome Editing

Recent research published in the journal “Science Bulletin” detailed the creation of a tool called ChCas12b that can accurately edit genomes and identify single-base mutations.

9 Dec 2024

New Discovery Reveals Unintended Genetic Damage in CRISPR-Cas9 Therapy

Genome editing with various CRISPR-Cas molecule complexes has progressed rapidly in recent years.

5 Dec 2024

AI Tool for Accelerating Biological Discovery

Brian Hie leads the Laboratory of Evolutionary Design at Stanford, focusing on the intersection of artificial intelligence and biology.

5 Dec 2024

From Yeast to Humans: Decoding the Link Between Nucleolar Size and Aging

Research reveals that nucleolar enlargement in yeast disrupts genomic integrity, linking size to lifespan and offering insights into aging mechanisms.

5 Dec 2024

Comprehensive Review of Intracellular Checkpoints in NK Cell Biology and Cancer

Natural killer (NK) cells play an important role in the innate immune response to cancer and viral infections, and their presence in tumors correlates with improved patient outcomes in a variety of cancers.

29 Nov 2024

Self-Eliminating e-Drive System Reverses Insecticide Resistance in Fruit Flies

Insecticides have been used for centuries to counteract widespread pest damage to valuable food crops. Eventually, over time, beetles, moths, flies and other insects develop genetic mutations that render the insecticide chemicals ineffective.

25 Nov 2024

How CRISPRi is Helping Combat Drug-Resistant Tuberculosis

Findings on isoniazid-resistant M. tuberculosis reveal key vulnerabilities, suggesting new avenues for treatment strategies against drug-resistant tuberculosis.

20 Nov 2024

CRISPR Reveals Hidden Functions of Noncoding RNA

Genes contain instructions for protein production, with the central dogma of biology stating that this information flows from DNA to RNA to proteins.

8 Nov 2024

Unveiling the Metabolic Strategies of Deep-Sea Coral-Associated Bacteria

Two incredible bacterial species have been found in the tissue of two deep-sea corals from the Gulf of Mexico by a German-American research team headed by Dr. Samuel Vohsen from Lehigh University in the USA and Professor Dr. Iliana Baums from the Helmholtz Institute for Functional Marine Biodiversity at the University of Oldenburg (HIFMB).

5 Nov 2024

3D Tumor Microenvironment Model Highlights Role of Ischemia and Acidification in Cancer Spread

Developed 3MIC model simulates tumor microenvironments, enabling direct observation of ischemic effects on cancer cell invasiveness and drug resistance.

4 Nov 2024

A New Understanding of Viral Infection

Scientists studying animal viruses with the potential to infect humans have discovered a critical protein that could facilitate the spread of a family of organisms known as arteriviruses.

1 Nov 2024

Unveiling the Molecular Mechanisms of CRISPR-Cas10's Cellular Shutdown

CRISPR-Cas9 can elegantly and precisely cut away any desired region of DNA and has long been compared to a type of genetic scissors.

29 Oct 2024

Unraveling the Mechanics Behind Transcription-Dependent Motions of Single Genes

A group of researchers has found unexpected links between genome packing, gene activity, and genome-wide motions, exposing features of the genome's structure that have a direct impact on gene expression and regulation.

23 Oct 2024

Advancements in Understanding Intestinal Hormone Secretion

A multi-institutional group of researchers led by the Hubrecht Institute and Roche's Institute of Human Biology has developed strategies to identify regulators of intestinal hormone secretion.

21 Oct 2024

Human Organoids Provide Insights Into Gut Hormone Release

A collaborative team of researchers from the Hubrecht Institute and Roche’s Institute of Human Biology has formulated strategies to identify the regulators involved in intestinal hormone secretion.

18 Oct 2024

New Approach Aims to Enhance CRISPR Safety and Precision

CRISPR is a revolutionary tool that allows scientists to precisely modify the genome and gene expression of cells in any organism.

8 Oct 2024

Mapping the Complex Structure and Function of CRISPR-Cas Protein Scissors

CRISPR-Cas systems help to protect bacteria from viruses. Several different types of CRISPR-Cas defense systems are found in bacteria, which differ in their composition and functions.

3 Oct 2024

Structural Discovery of Fanzor Proteins Offers New Directions in Genome Engineering

A revolution in biomedicine is currently underway, driven by the application of genome engineering tools such as the prokaryotic CRISPR-Cas9.

3 Oct 2024

Enhancing Global Nutrition Through Gene-Edited High-Protein Crops

A Mississippi State biologist's groundbreaking research in improving global nutrition and sustainability is featured this week in New Phytologist, a leading plant biology journal.

26 Sep 2024

New Gene Editing Tool Shows Promise for Treating Diseases

Bacterial and archaeal CRISPR-Cas systems, comprising protein and RNA components, were initially developed as a natural defense mechanism against invading viruses.

24 Sep 2024