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Drugs used for myelodysplastic syndrome could potentially activate a sleeping oncogene

Hypomethylating agents (HMA) are currently used as a first-line treatment for patients with myelodysplastic syndrome (MDS) - a group of disorders where there is insufficient production of healthy mature blood cells in the bone marrow - and increasingly in other diseases, but their mechanism of action remains unclear.

From National University of Singapore (NUS) 27 May 2022

Genetic testing advances help to uncover primary immune deficiency diseases

Infections caused by primary immunodeficiency diseases (PID) can be persistent and life-threatening. More than 450 PIDs have been identified, yet diagnosing them quickly and accurately remains a difficulty.

27 May 2022

Easy-to-find soft corals make the elusive "anti-cancer" compound, scientists report

The bottom of the ocean is full of mysteries but scientists have recently uncovered one of its best-kept secrets. For 25 years, drug hunters have been searching for the source of a natural chemical that had shown promise in initial studies for treating cancer.

From The University of Utah 24 May 2022

Researchers devise a new treatment approach to cure aggressive brain tumors

Glioblastomas (GBMs) are cancerous tumors of the brain and spinal cord that are incredibly aggressive.

23 May 2022

Immune-boosting drugs with antibiotics may reduce the health risks of fungal infections

Patients are more susceptible to fungal infections because the immune system in the gut is disrupted when patients are given antibiotics in the hospital.

18 May 2022

Research shows how visible hotspots may be easy to target with immune-stimulating drugs

Many cancers include genetic “hotspots,” or sections of DNA that are subject to mutation. For example, a mutation in the TP53 gene is found in more than 50% of all cancers, generally within a narrow DNA range.

18 May 2022

Scientists detect rare genetic signs of drug-resistant tuberculosis with the aim to stop disease progression

Many people believe tuberculosis (TB) is a disease of the past. Nonetheless, it claims over a million lives each year. Furthermore, the problem is escalating as Mycobacterium tuberculosis—the pathogen that causes tuberculosis develops resistance to the antibiotics used to treat the disease.

12 May 2022

Researchers highlight a phage-antibiotic combo against antibiotic-resistant superbug

A preclinical study performed by Monash University researchers discovered that utilizing a combination of phages and antibiotics to treat bacterial infections may be considerably more successful than using the drugs separately.

12 May 2022

Elective course in biodesign enables students to expand their abilities as medical device innovators

Educators at the Renaissance School of Medicine (RSOM) at Stony Brook University highlighted the success of their three-year, elective course in biodesign that has enabled students to expand their abilities as innovators to creating potential medical devices for the future.

11 May 2022

eTesting cannabis for impurities and contaminants

In this interview, Shianna Hines, the Senior Field Application Scientist for cannabis and hemp-related items at PerkinElmer, talks to AZoLifeSciences about testing cannabis for impurities and contaminants.

From PerkinElmer 11 May 2022

Trial assesses the impact of Mediterranean diet on depression symptoms in young men

Depression is a common mental health condition that affects approximately 1 million Australians each year. It is a significant risk factor for suicide, the leading cause of death in young adults.

10 May 2022

bit.bio launches Huntington’s disease human cell model

First neurodegenerative disease model launched from bit.bio's new ioDisease Model portfolio.

From bit.bio 10 May 2022

New technique uses genetic data that may better predict disease risk in a population

Polygenic risk scores (PRS) are promising tools for forecasting disease risk, but current versions have bias built-in, which can reduce their accuracy in some populations and lead to health disparities.

10 May 2022

Study shows new potential target for CAR T cells to inhibit solid tumors

CAR T therapy, or chimeric antigen receptor T-cell therapy, has revolutionized the treatment of some blood cancers, allowing patients with relapsed or refractory disease to live longer and better lives.

10 May 2022

New sensor to detect early-stage lymphedema could spare thousands of patients a year

A sensor created by Johns Hopkins University graduate students to detect very early-stage lymphedema could spare thousands of patients a year, many women with breast cancer, from the painful, debilitating condition.

3 May 2022

Gene expression signatures in lymph node cells play an active role in lymphoma development

Researchers from the University of Tsukuba identify gene expression signatures in different types of lymph nodes cells that play an active role in the development of lymphomas.

3 May 2022

Scientists reveal how autism-linked genetic mutation disrupts neural development using mini-brains

In a study published May 02, 2022 in Nature Communications, scientists at University of California San Diego School of Medicine used human brain organoids to reveal how a genetic mutation associated with a profound form of autism disrupts neural development.

From UC San Diego 3 May 2022

Study shows the role of mucosal-associated invariant T cell in mucosal melanomas patients

Many cancer patients have benefited from the development of anti-cancer immunotherapy drugs known as immune checkpoint inhibitors, but patients with mucosal melanomas—melanomas that occur in the mucous membranes of the head, neck, eyes, respiratory system, and genitourinary region rather than on the skin—are highly resistive to immune checkpoint inhibitors for reasons researchers do not fully understand.

29 Apr 2022

Regulatory framework of stem cell-based therapy in China

Clinical researches of stem cell-based therapies are highly active in China, while it was arduous to determine the most effective way of clinical translation of those advanced therapies.

25 Apr 2022

Safety, feasibility of intranasal human milk as stem cell therapy for preterm infants with intraventricular hemorrhage

A new study demonstrates that intranasal human milk is a safe and feasible intervention for intraventricular hemorrhage, a serious cause of morbidity in preterm infants.

25 Apr 2022

Clinical News and Research

Drugs used for myelodysplastic syndrome could potentially activate a sleeping oncogene

Genetic testing advances help to uncover primary immune deficiency diseases

Easy-to-find soft corals make the elusive "anti-cancer" compound, scientists report

Researchers devise a new treatment approach to cure aggressive brain tumors

Immune-boosting drugs with antibiotics may reduce the health risks of fungal infections

Research shows how visible hotspots may be easy to target with immune-stimulating drugs

Scientists detect rare genetic signs of drug-resistant tuberculosis with the aim to stop disease progression

Researchers highlight a phage-antibiotic combo against antibiotic-resistant superbug

Elective course in biodesign enables students to expand their abilities as medical device innovators

eTesting cannabis for impurities and contaminants

Trial assesses the impact of Mediterranean diet on depression symptoms in young men

bit.bio launches Huntington’s disease human cell model

New technique uses genetic data that may better predict disease risk in a population

Study shows new potential target for CAR T cells to inhibit solid tumors

New sensor to detect early-stage lymphedema could spare thousands of patients a year

Gene expression signatures in lymph node cells play an active role in lymphoma development

Scientists reveal how autism-linked genetic mutation disrupts neural development using mini-brains

Study shows the role of mucosal-associated invariant T cell in mucosal melanomas patients

Regulatory framework of stem cell-based therapy in China

Safety, feasibility of intranasal human milk as stem cell therapy for preterm infants with intraventricular hemorrhage

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