Cytokine News and Research

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Clinical trial shows CAR-T cell therapy can be used for treating Hodgkin lymphoma

CAR-T cell therapy, which attacks cancer cells using a person's reprogrammed immune cells, has been used to treat Hodgkin lymphoma with remarkable success for the first time, according to the results of an early phase clinical trial led by researchers at UNC Lineberger Comprehensive Cancer Center and Baylor College of Medicine in Houston.

24 Jul 2020

New approach is more effective in treating certain blood cancers

Some of the most promising advances in cancer treatment have centered on immunotherapies that rev up a patient's immune system to attack cancer.

24 Jul 2020

Type 1 interferon deficiency in the blood could be a hallmark of severe COVID-19

Approximately 5% of people with Covid-19 progress to a severe or critical form, including the development of severe pneumonia that progresses to acute respiratory distress syndrome.

20 Jul 2020

Targeted radionuclide therapy creates a favorable tumor microenvironment in prostate cancer

Targeted radionuclide therapy has been found to create a favorable tumor microenvironment in prostate cancer that improves the effectiveness of immunotherapies.

14 Jul 2020

Single dose of tocilizumab improves survival in critically ill COVID-19 patients

Critically ill COVID-19 patients who received a single dose of a drug that calms an overreacting immune system were 45% less likely to die overall, and more likely to be out of the hospital or off a ventilator one month after treatment, compared with those who didn't receive the drug, according to a new study by a team from the University of Michigan.

14 Jul 2020

New spatial mapping method pinpoints new potential therapeutic targets for lupus

A team of researchers from Children's Hospital of Philadelphia used a new method of pinpointing potential disease-causing changes in the genome to identify two new potential therapeutic targets for lupus, while also paving the way for more accurately identifying disease-causing variations in other autoimmune disorders.

9 Jul 2020

How upregulation of a single gene by SARs-CoV-2 can trigger cytokine storm

The SARS-CoV-19 virus initially has a limited capability to invade, attacking only one intracellular genetic target, the aryl hydrocarbon receptors (AhRs).

29 Jun 2020

Females rely on anti-inflammatory T cells for blood pressure control

In the face of a multipronged front to drive blood pressure up, including a high-salt diet, females are better able to keep their pressure down by increasing levels of a T cell that selectively dials back inflammation, scientists say.

23 Jun 2020

Dysfunctional placenta can contribute to Cornelia de Lange syndrome

Researchers have demonstrated that a dysfunctional placenta can play a formerly unknown role during the earliest phases of development in Cornelia de Lange.

17 Jun 2020

Skeletal muscles help to keep the immune system functional in chronic diseases

In the fight against cancer or chronic infections, the immune system must be active over long periods of time.

16 Jun 2020

BCG vaccine elicits trained immunity in humans

A tuberculosis vaccine developed 100 years ago also makes vaccinated persons less susceptible to other infections.

16 Jun 2020

Deleting a key gene to create an immune cell with stronger anti-tumor activity

Using induced pluripotent stem cells (iPSCs) and deleting a key gene, researchers at University of California San Diego School of Medicine have created natural killer cells -- a type of immune cell -- with measurably stronger activity against a form of leukemia, both in vivo and in vitro.

From UC San Diego 12 Jun 2020

Direct Control Of Dendritic Cells For Tracking And Immune Modulation

Dendritic cells are one of our bodies' first line of defense and are stationed like sentinels at all surfaces, as well as in most of our organs.

19 May 2020

Coronavirus attacking microRNA numbers reduce with age

A group of tiny RNA that should attack the virus causing COVID-19 when it tries to infect the body are diminished with age and chronic health problems, a decrease that likely helps explain why older individuals and those with preexisting medical conditions are vulnerable populations, investigators report.

14 May 2020