DNA Replication News and Research

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DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "semiconservative" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication.
Revealing the unappreciated role of POLQ in responding to DNA replication stress

Revealing the unappreciated role of POLQ in responding to DNA replication stress

Revealing the functional significance of DDX41 in great detail

Revealing the functional significance of DDX41 in great detail

Enzymes hold the answer to understanding how DNA mutates

Enzymes hold the answer to understanding how DNA mutates

Revealing cancer development in people carrying inherited BRCA1 mutations

Revealing cancer development in people carrying inherited BRCA1 mutations

A strong enzyme that functions similar to a Swiss army knife

A strong enzyme that functions similar to a Swiss army knife

SLFN11’s surveillance part in protein homeostasis

SLFN11’s surveillance part in protein homeostasis

Researchers discover potential ways to comprehend DNA replication

Researchers discover potential ways to comprehend DNA replication

Single-molecule analysis to study how tetraploid cells replicate DNA from diploid cells

Single-molecule analysis to study how tetraploid cells replicate DNA from diploid cells

Cryo-electron microscopes help determine how “911” molecule repairs DNA damage

Cryo-electron microscopes help determine how “911” molecule repairs DNA damage

Scientists reveal how 9-1-1 clamp attaches to DNA damage site for initiating effective repair

Scientists reveal how 9-1-1 clamp attaches to DNA damage site for initiating effective repair

Yale and uOttawa researchers partner to solve a puzzle rooted in the deepest past of evolution

Yale and uOttawa researchers partner to solve a puzzle rooted in the deepest past of evolution

Scientists discover new details on vital enzyme that allows for DNA sequencing

Scientists discover new details on vital enzyme that allows for DNA sequencing

Research develops novel ways to recreate totipotency by cellular reprogramming

Research develops novel ways to recreate totipotency by cellular reprogramming

New proteomics method identifies proteins responsible for regulating R-loop levels in human cells

New proteomics method identifies proteins responsible for regulating R-loop levels in human cells

Study provides insight into replication and transcription machinery of ranaviruses

Study provides insight into replication and transcription machinery of ranaviruses

Experts identify proteins that regulate dual processes

Experts identify proteins that regulate dual processes

Live-cell probes enable visualization of the elongation phase of transcription

Live-cell probes enable visualization of the elongation phase of transcription

Scientists test the accuracy of enzymes that copy DNA under weightlessness

Scientists test the accuracy of enzymes that copy DNA under weightlessness

Experts analyze key protein complexes involved in DNA replication and repair

Experts analyze key protein complexes involved in DNA replication and repair

Researchers develop artificial genomic DNA capable of replication and evolution

Researchers develop artificial genomic DNA capable of replication and evolution