DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "semiconservative" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication.
Cryogenic electron microscopy (cryo-EM) allows scientists to investigate the assembly of DNA replication machinery where DNA is damaged.
Professor Norikazu Ichihashi and his colleagues at the University of Tokyo have successfully induced gene expression from a DNA, characteristic of all life, and evolution through continuous replication extracellularly using cell-free materials alone, such as nucleic acids and proteins for the first time.
In this interview, we speak to Dr. Miguel J. Xavier about his latest research into male infertility and how de novo mutations may play a part.
The hereditary material, DNA, interacts with proteins present in the cell nuclei and forms a tightly packed complex with proteins called “chromatin”.
Recent research at the University of Bath reveals that tangles in unwound DNA can develop mutational hotspots in the genomes of bacteria.
Scientists took a further step in the exploration of genetic instability, as exhibited in cancer cells.
Are prematurely aged or overworked stem cells a significant factor in chronic lung disease? Findings of a study just released in STEM CELLS Translational Medicine (SCTM) say this is likely so.
Researchers at the Institute of Molecular Biology and Johannes Gutenberg University Mainz have developed a method to engineer new functionalities into cells. The results were published today in the journal Cell in the article "Dual film-like organelles enable spatial separation of orthogonal eukaryotic translation".
Cornell researchers have identified a new way to measure DNA torsional stiffness – how much resistance the helix offers when twisted – information that can potentially shed light on how cells work.
According to recent research, the mutations giving rise to melanoma are the outcome of a chemical conversion in DNA triggered by sunlight.
Following the p53 tumor suppressor gene, the genes encoding two proteins of the SWI/SNF chromatin remodeling complex are the most often identified mutated.
Researchers from the Indian Institute of Technology Bombay shed light on the origins of Mimivirus and other giant viruses, helping us better understand a group of unique biological forms that shaped life on earth.
While the CRISPR-Cas9 gene editing system has become the poster child for innovation in synthetic biology, it has some major limitations.
A University of Hong Kong research team has created a novel chemical method for illustrating protein interaction networks in cells.
Researchers have discovered how specific proteins ensure the rectification of errors introduced into the DNA when it replicates.
A research team from Italy has discovered a pair of microRNA molecules that assist in maintaining a population of cancerous stem cells that fuel the growth of breast cancers and trigger tumor relapse after treatment.
Low representation of minority groups in public genomic databases may affect therapy selection for Black patients with cancer, according to new Mayo Clinic research published in npj Precision Oncology.
A toxin produced by bacteria as a defense mechanism causes mutations in target bacteria that could help them survive, according to a study published today in eLife.
Chemotherapy not only attacks cancer cells but also targets all cells in the human body. This is the reason why patients receiving this treatment generally experience adverse side effects, like hair loss, physical weakness, and nausea.
Many proteins are required to maintain the structure, and to preserve the genetic integrity, of DNA. Sliding clamps are proteins that increase the efficiency of DNA replication.