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Boosting Confocal Microscopy Through Artificial Intelligence

In this interview, we speak to Dr. Hari Shroff from the National Institute of Biomedical Imaging and Bioengineering about his latest research into confocal microscopy.

From National Institute of Biomedical Imaging and Bioengineering (NIBIB) 20 Dec 2021

New methods help chemists to understand how bacteria turn light into chemical energy

Chemists have come to a deeper understanding of how photosynthetic bacteria convert light into chemical energy and discovered why one step in the process may be more robust than previously realized, according to a new study published this week in Proceedings of the National Academy of Sciences.

17 Dec 2021

Findings of a new study likely to help design fluorescent, protein-based sensors

Proteins, the molecular machines, make all living organisms hum. They are capable of healing cells, preventing deadly infections, and more.

4 Oct 2021

New datasets published to better train ML models for drug discovery

Polymorphs are molecules that have different molecular packing arrangements despite identical chemical compositions. In a recent paper, researchers at GlaxoSmithKline (GSK) and the Cambridge Crystallographic Data Centre (CCDC) combined their proprietary (GSK) and published (CCDC) datasets to better train machine learning (ML) models to predict stable polymorphs to use in new drug candidates.

4 Oct 2021

Pairing microscopy with AI to develop a rapid, accurate COVID-19 test

Beckman researchers paired microscopy with artificial intelligence to develop a COVID-19 test that's fast, accurate, and cost-effective. All we need to do is say "ahh."

13 Sep 2021

Researchers employ 3D holographic microscopy to visualize bioplastic in living cells

Scientists from KAIST inspected the accumulation of bioplastic granules in living bacterial cells with the help of 3D holographic microscopy.

29 Jul 2021

$Microcrystal electron diffraction could help obtain potential pharmaceutical structures$

Microcrystal electron diffraction could help obtain potential pharmaceutical structures

In the process of drug development, solving structures of potential therapeutics with X-ray diffraction (XRD) has been a presumed, critical step so far.

16 Jul 2021

Study measures the mass of human chromosomes using X-rays for the first time

In a recent study led by UCL researchers, the mass of human chromosomes was quantified using X-rays for the first time.

From University College London 3 Jun 2021

First real-time observation of DNA-histone interactions

The genetic material of most organisms is carried by DNA, a complex organic molecule. DNA is very long -- for humans, the molecule is estimated to be about 2 m in length.

2 Jun 2021

Researchers develop an unprecedentedly flexible new DNA staining probe

A team of scientists at Nagoya University in Japan has invented an extremely versatile DNA fluorescent dye called “Kakshine".

17 May 2021

Holographic histopathology increases imaging speed, resolution for diagnostics

Histology involves the investigation of biological tissues at the microscopic level. Histology is also known as microscopic anatomy and is commonly used to diagnose cancer and other diseases.

3 May 2021

Study reveals novel antibody binding implicated in liver and breast cancer

In the field of structural biology, certain molecules are so uncommon that they can only be captured with a special set of tools.

18 Feb 2021

Research may help better understand the biochemistry underlying catalysis in cells

Investigators from the Institute of Scientific and Industrial Research at Osaka University, together with the Hiroshima Institute of Technology, have announced the discovery of a new protein that allows an organism to conduct an initial and essential step in converting amino acid residues on a crosslinked polypeptide into an enzyme cofactor.

From Osaka University 11 Feb 2021

Researchers develop novel nanobodies against SARS coronavirus-2

An international research team led by the University of Bonn has identified and further developed novel antibody fragments against the SARS coronavirus-2. These "nanobodies" are much smaller than the classic antibodies used to treat US President Donald Trump, for example.

13 Jan 2021

Researchers determine atomic structure of coronavirus protein linked to disease severity

A team of HIV researchers, cellular biologists, and biophysicists who banded together to support COVID-19 science determined the atomic structure of a coronavirus protein thought to help the pathogen evade and dampen response from human immune cells.

13 Jan 2021

Research shows magnesium contact ions stabilize complex folded structure of tRNA

In cells transfer RNA (tRNA) translates genetic information from the encoding messenger RNA (mRNA) for protein synthesis.

10 Dec 2020

Scientists elucidate the structure of ABC transporter protein

A high concentration of salt or sugar in the environment will dehydrate microorganisms and stop them from growing.

19 Nov 2020

Glass surface embedded with self-assembled gold nanoparticles can improve live-cell imaging

In the quest to image exceedingly small structures and phenomenon with higher precision, scientists have been pushing the limits of optical microscope resolution, but these advances often come with increased complication and cost.

9 Nov 2020

Combination of microscopy and machine learning helps detect fossil pollen grains

Plant biology researchers at the University of Illinois and computer scientists at the University of California Irvine have developed a new method of fossil pollen identification through the combination of super-resolution microscopy and machine learning.

27 Oct 2020

New software helps analyze individual cells in virtual reality

New virtual reality software now enables scientists to “walk” inside and examine individual cells.

14 Oct 2020