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Unveiling the Neural Basis of Number Sense in Rats

The existence of discrete number sense in rats has been confirmed by research co-led by neuroscientists Professor Yung Wing-ho from City University of Hong Kong (CityUHK) and Professor Ke Ya from The Chinese University of Hong Kong (CUHK) Faculty of Medicine (CU Medicine).

16 Apr 2024

New Platform Reveals Individual Sensitivity to Disease-Causing Mutations

In humans, the exact same mutation in a specific gene can produce widely different outcomes. It's a bit like adding the same amount of salt to different recipes-;the effect on the finished dish can be quite different, depending on the mix of other ingredients.

4 Apr 2024

Cryo-EM Imaging Unveils Similar Protein Structures in Alzheimer's and Down Syndrome

More than 90% of people with Down syndrome, the most common chromosomal disorder in humans and the most frequent genetic cause of intellectual disability, are diagnosed with Alzheimer's disease by ages 55-60.

30 Mar 2024

Canadian-Led Study Identifies Genetic Links to Cerebral Palsy

A Canadian-led study has identified genes which may be partially responsible for the development of cerebral palsy.

29 Mar 2024

Study Identifies Protein Key to Preserving Neuronal Identity

Epigenetic processes allow different cell types to emerge from a single genome. Throughout development, cells differentiate and acquire distinct characteristics by expressing the same genome in different ways.

13 Mar 2024

Blood-Based Markers Unveil Secrets of Biological Aging

University of Pittsburgh researchers have uncovered blood-based markers linked with healthy and rapid aging, allowing them to predict a person's biological age -; how fast a person's cells and organs age regardless of their birthdate.

11 Mar 2024

Researchers Unveil a Key Gene with a Central Role in Learning and Memory Across Mammalian Brain Cells

Discoveries in mice could guide the quest for treatments aimed at addressing brain developmental disorders in children with SYNGAP1 gene mutations.

1 Mar 2024

Gut Microbial Metabolite Linked to Increased Thrombosis Risk in COVID-19 Patients

A gut microbial metabolite called 2-methylbutyrylcarnitine (2MBC) plays a role in exacerbating thrombosis -- the formation of blood clots – researchers report February 23rd in the journal Cell Metabolism.

26 Feb 2024

Mayo Clinic Researchers Analyze Zombie Cells to Explain Aging

With age, cells can experience senescence, a state where they stop growing but continue releasing inflammatory and tissue-degrading molecules.

16 Feb 2024

Researchers Identify Genes Linked to Genomic Instability and DNA Damage

More than one hundred key genes linked to DNA damage have been uncovered through systematic screening of nearly 1,000 genetically modified mouse lines, in a new study published today (14 February) in Nature.

16 Feb 2024

New Research Finds Placenta Cells May Lower Blood Pressure

Scientists from La Trobe University and the Hudson Institute have demonstrated that cells from placentas could have therapeutic benefits for patients suffering from high blood pressure.

1 Feb 2024

Prime Editing and Base Editing Could Revolutionize Treatment for Phenylketonuria

Phenylketonuria (PKU) is a rare newborn genetic disease that impacts between 1 in 10,000 to 1 in 20,000 people, depending on the individuals' genetic ancestry. PKU causes an amino acid-;called phenylalanine (Phe)-;to build up in the bloodstream.

3 Nov 2023

Fruit Fly Model Provides Insights into Pathogenesis of New Genetic Disorder

Research conducted in the laboratory of Dr Hugo J. Bellen, a Distinguished Service Professor at Baylor College of Medicine and a principal investigator at the Jan and Dan Duncan Neurological Research Institute (Duncan NRI) at Texas Children's Hospital, has identified a novel disorder linked to gain-of-function variants in the DOT1L gene.

16 Oct 2023

Epigenetic Regulator MOF Plays Critical Role in Mitochondrial Function

The intricate control of cellular metabolism relies on the coordinated and harmonious interplay between the nucleus and mitochondria.

10 Oct 2023

Study Links Autism Gene to Broad Spectrum of Molecular and Cellular Defects

Researchers have used CRISPR gene editing, stem cells and human neurons to study the impact of a gene that is commonly mutated in autism.

6 Oct 2023

NSL Complex Regulates Intraciliary Transport Genes in Multiple Cell Types

The non-specific lethal (NSL) complex is a chromatin-associated factor that has been shown in both fruit flies and mammals to regulate the expression of thousands of genes. Abrogation of the NSL genes causes the organism to die, which gives rise to the complex’s unusual name.

28 Aug 2023

Schizophrenia-Linked Chromosome Deletion Affects Mitochondria

Investigators are learning more about how schizophrenia develops by investigating the most powerful known genetic risk factor.

22 Aug 2023

Researchers Pinpoint the Genes that Shape the Skeletons

Using artificial intelligence to analyze tens of thousands of X-ray images and genetic sequences, researchers from The University of Texas at Austin and New York Genome Center have been able to pinpoint the genes that shape our skeletons, from the width of our shoulders to the length of our legs.

21 Jul 2023

New Study Highlights Genetic Variations for a Precision Medicine Approach

There are genetic variations among children with a rare neurodevelopmental disease, according to a new study headed by the Seaver Autism Center for Study and Treatment at Mount Sinai. This discovery could set the path for a precision medicine approach to treating these children.

18 Jul 2023

Novel Drug Compound Reduces Sensory Hypersensitivity in Fragile X Mice

Boosting the activity of inhibitory interneurons in Fragile X mice reduced their hypersensitivity to sensory stimuli, according to a new Neuron study led by UCLA Health researchers.

14 Jul 2023