Epilepsy is a group of disorders marked by problems in the normal functioning of the brain. These problems can produce seizures, unusual body movements, a loss of consciousness or changes in consciousness, as well as mental problems or problems with the senses.
Throughout development, life and the processes of aging, all human cells accumulate mutations, resulting in what is called mosaicism, a condition in which different cells in the same person have different DNA sequences or genetic makeup.
When we think of the brain, we think of neurons. But much of the brain is made of non-neuronal cells called glial cells, which help regulate brain development and function.
Current neural network algorithms produce impressive results that help solve an incredible number of problems.
A research team has revealed that neural stem cells (NSCs)—that is, the stem cells of the nervous system—age quickly.
For a long time, researchers have attempted to gain better insights into the development of the cerebral cortex and its layers, since pathologies are associated with this process.
Researchers from Children's Hospital of Philadelphia (CHOP) affiliated with the CHOP Epilepsy Neurogenetics Initiative (ENGIN) have compiled a complete genetic and clinical analysis of more than 400 individuals with SCN2A-related disorder, which has been linked to a variety of neurodevelopmental disorders, including epilepsy and autism.
Scientists have identified a strong connection between genetic modifications known to cause cerebral palsy and neurodevelopmental disabilities.
Improvements in DNA sequencing have revealed a rare syndrome triggered by changes in the SATB1gene.
Certain anchor proteins inhibit a key metabolic driver that plays an important role in cancer and developmental brain disorders.
As COVID cases rise, physically distancing yourself from other people has never been more important. Now a new UCLA study reveals how your brain navigates places and monitors someone else in the same location.
An important part of the brain's immune system, cells called microglia constantly extend and retract "branches" from their cell body to survey their environment.
In the orchestra of the brain, the firing of each neuron is controlled by two notes--excitatory and inhibitory-- that come from two distinct forms of a cellular structure called synapses.
Researchers at Linköping University, Sweden, have discovered a new mechanism by which substances can open a certain type of ion channel and in this way regulate nerve impulses.
Epilepsy, results from impairment in brain cells and is often treated with drugs that counteract or control the seizures.
A UC Davis MIND Institute study of pregnant mice found that high amounts of folic acid during pregnancy harmed the brain development of embryos.
Some highly selective drugs cause unexpected effects in nerve cells: they not only reduce the activation of certain receptors, but also their inactivation.
Hard skulls help protect our brains from physical injuries.In addition to a tough outer shell, brains have internal defenses, including a powerful shield called the blood-brain barrier that defends brain cells from substances in the bloodstream that are toxic and dangerous to nerve cells. If the blood-brain barrier is breached, then health problems arise.
Scientists have identified a novel mechanism that is responsible for causing the abnormal development of neuronal connections in the mice brain.
A team of researchers at Children's Hospital of Philadelphia affiliated with the CHOP Epilepsy Neurogenetics Initiative (ENGIN) have combined clinical information with large-scale genomic data to successfully link characteristic presentations of childhood epilepsies with specific genetic variants.
In this breakthrough method, parasitic worms are prevented from using alternative metabolism routes offered by microbes living inside them.