Epilepsy is a group of disorders marked by problems in the normal functioning of the brain. These problems can produce seizures, unusual body movements, a loss of consciousness or changes in consciousness, as well as mental problems or problems with the senses.
One of the epilepsy types that are most prevalent worldwide is temporal lobe epilepsy (TLE). Although there are symptomatic medications available, one-third of TLE patients are still not responding to the current course of treatment, necessitating the urgent need for new drug targets.
The mTOR protein is important for cell growth, proliferation, and survival. Its activity fluctuates according to nutrient availability and growth factors like hormones.
Not just three, but even five proteins share important roles in the formation and function of synapses and can substitute for each other. This discovery was made by a team of the research focus "Mental Health & Neuroscience" of the Karl Landsteiner University of Health Sciences Krems (KL Krems) and the CavX PhD program of the Medical University of Innsbruck.
An RNA-based editing tool has been developed by Duke University researchers, which targets specific cells rather than genes. Any cell type can be precisely targeted, and any protein of interest can be added only to that cell type.
Researchers from Tohoku University have now shown that the consolidation and extinction of contextual fear conditioning alter the microglial genes connected to the synapse—structures that permit neurons to communicate with one another.
The UCLA creators of a miniature microscope that can be mounted on the heads of lab animals to provide an invaluable view into the brain's inner workings have received a $4 million grant from the National Institutes of Health to develop next-generation versions of their "miniscope."
A single gene that was previously discovered to be the main factor in a rare disease associated with epilepsy, autism, and developmental delay has been named as a key player in the development of healthy neurons.
For the first time, researchers have deciphered the atomic structure of a protein that transports one of the body’s most vital neurotransmitters into neurons.
The brain has the potential to change the way neurons communicate with one another. That is how it prevents out-of-control brain activity. Scientists have discovered a mechanism that plays a key role in this.
According to a study headed by researchers from USC Stem Cell and the USC Neurorestoration Center, adults may recover at least some of what they have lost by producing new brain cells, and this process is profoundly modified in patients with long-term epilepsy.
Researchers from a USC-led consortium have discovered 15 "hotspots" in the genome that either speed up brain aging or slow it down -; a finding that could provide new drug targets to resist Alzheimer's disease and other degenerative brain disorders, as well as developmental delays.
CHARGE syndrome, which affects approximately one in 10,000 newborns worldwide, is associated with neurological and behavioral conditions like intellectual disability, attention deficit disorder, convulsions, and autism.
Scientists at UT Southwestern have discovered a four-protein complex that seems to play a significant function in the formation of ribosomes, which serve as protein factories for cells, as well as a surprise role in neurodevelopmental diseases.
Microglia, the immune cells of the brain, are known for eating up unwanted items like germs and debris, much as their counterparts do in the rest of the body.
In a study led by Cedars-Sinai, researchers have discovered two types of brain cells that play a key role in dividing continuous human experience into distinct segments that can be recalled later.
Scientists at UCL have developed a new technique that uses microscopic magnetic particles to remotely activate brain cells; researchers say the discovery in rats could potentially lead to the development of a new class of non-invasive therapies for neurological disorders.
Salk researchers have programmed mammalian cells to be stimulated with ultrasound.
An international team of scientists has used atlases of the human brain informed by genetics to identify hundreds of genomic loci. Loci is plural for locus, and in genetics indicates the physical location of a gene or variant on a chromosome.
Although several people think of medicines as purely synthetic compounds, nature is an important element of most of the medications humans depend on.
Researchers at UC San Francisco have cataloged all of the cells that make up the blood vessels in the human brain, as well as their positions and the genes produced.