Estrogens are a family of related molecules that stimulate the development and maintenance of female characteristics and sexual reproduction.
Enhancing treatment options for triple-negative breast cancer (TNBC), a highly aggressive tumor with a grim prognosis and limited therapeutic possibilities has proven to be a formidable challenge.
Scientists at the Max Planck Institute for Chemical Ecology in Jena are investigating the previously largely unknown biosynthetic pathway that leads to the formation of cardenolides in plants.
A new editorial paper was published in Oncotarget's Volume 14 on June 12, 2023, entitled, "Are cis-spliced fusion proteins pathological in more aggressive luminal breast cancer?"
Most immunotherapies that aim to increase T cell activity are ineffective in treating estrogen receptor-positive (ER+) breast cancer. A new study of invasive ER+ breast cancers led by researchers at the University of Pittsburgh School of Medicine implies that targeting a different type of immune cell called macrophages may be a more effective approach.
Most immunotherapies, which aim to boost T cell activity, work poorly in treating estrogen receptor-positive (ER+) breast cancer.
Typically, tumor cells change their energy metabolism and take in more glucose to enable their rapid division and spread. As a result, the body’s immune response to cancer is suppressed by limiting the immune cells’ access to glucose.
UT Southwestern Medical Center researchers have discovered a method cells use to turn genes on and off that involves portions of proteins whose function has long been a mystery.
According to the findings of a meta-analysis proposed at the San Antonio Breast Cancer Symposium held on December 6–10th, 2022, patients with invasive breast cancer who had low scores on an investigational gene molecular signature seemed to have similar rates of local recurrence regardless of whether they received adjuvant radiation therapy after breast-conserving surgery.
Everyone must have heard about cholesterol and how important it is to eat heart-healthy meals to keep it under control.
Boosting milk yield when included in the diet at sufficient levels, lysine is an important amino acid for dairy cows. But how could lysine be advantageous for cows in other means? A new study by the University of Illinois reveals that rumen-protected lysine can enhance uterine health if given in the transition period.
According to a recent study conducted by scientists at Emory University in Atlanta, the administration of broad-spectrum antibiotics in mice with malignant melanoma, an aggressive type of skin cancer, expedited their metastatic bone growth.
Researchers at Johns Hopkins Medicine claim to have discovered significant molecular variations between cancer cells that adhere to an initial tumor and those that spread out to develop distant tumors while researching the fatal form of breast cancer known as triple negative.
A new study presented at ENDO 2022, the Endocrine Society’s annual meeting in Atlanta, Ga., suggests that probiotic bacteria may improve the anti-cancer actions of the breast cancer drug tamoxifen as well as other endocrine-targeted therapies, potentially lowering the risk of estrogen receptive positive (ER+) breast cancer.
The most prevalent type of cancer detected in women is breast cancer (BC). BC is the second biggest cause of death among female cancer patients globally.
The pancreas secretes around a cup of digestive juices per day—a mixture of molecules capable of breaking down the food people consume.
A mutated gene found in more than 20% to 30% of breast cancer recurrences may help tumors become more aggressive and promote metastasis, according to a pair of new studies that uncover mechanisms behind these processes and point to new therapy targets.
When it comes to assessing the effects of endocrine-disrupting chemicals (EDCs) or toxins on cancers and other diseases, which target a variety of mechanisms, including the estrogen receptor (ER), one size does not always fit all.
Researchers combined advanced computational methods with experimental studies to gain new insight, at the cell level, into how the plant compound formononetin might be used to treat food allergies.
Researchers from Clemson University have found a genetic variation linked to a potentially fatal esophageal disease common in German shepherd dogs.
The IL-6 protein family has a poor reputation for promoting inflammation, arthritis, autoimmune disease, and even cancer.