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Novel targeted therapy blocks critical metabolic pathways in cancer cells

Scientists have designed a new targeted therapy, known as POMHEX, which inhibits vital metabolic pathways in tumor cells containing specific genetic defects.

24 Nov 2020

Scientists use new technology to observe DNA defects in children with Fanconi anemia

Scientists have successfully utilized a novel stem cell technology to examine the skin, specific to a group of living patients, in laboratory settings.

24 Nov 2020

Researchers use metal-organic frameworks to target prostate cancer cells

Scientists have used metal-organic frameworks to effectively deliver the CRISPR/Cas9 genetic snipping tool into human cancer cells.

23 Nov 2020

Architecture of cell nucleus can change gene activity in plants

Scientists from the University of Tokyo have learned how the layout of the cell nucleus can alter the activity of genes found in plants.

23 Nov 2020

First functional analysis of cytokine IL-15L using rainbow trout

The cytokine family including interleukin-2 and -15 (IL-2 and IL-15) started out in a primitive vertebrate species with three related cytokines IL-2, IL-15, and IL-15-like (IL-15L), all sharing binding capacity for receptor chain IL-15Rα. IL-15L was conserved in fishes, reptiles, and some mammals but lost in humans and mice.

23 Nov 2020

Scientists discover how abnormal proteins unleash latent toxicity in neurodegenerative diseases

Thanks to modern medicine, humans tend to live much longer than before. Unfortunately, this also opens a wider window to develop chronic diseases with late-onset, such as neurodegenerative diseases.

23 Nov 2020

Gaining new insights into bacterial pneumonia

Jacqueline Kimmey speaks to AZoLifeSciences about her research into bacterial pneumonia and the genes that drive its spread from the lungs into the blood.

From University of California Santa Cruz 23 Nov 2020

Scientists discover new functions of key cellular machine involved in human cancers

Utah scientists have discovered new functions of a key cellular machine that regulates gene packaging and is mutated in 20% of human cancers. The study was published in print today in the journal Molecular Cell.

20 Nov 2020

Endogenous viral elements play important role in genome evolution of green algae

Viruses are tiny invaders that cause a wide range of diseases, from rabies to tomato spotted wilt virus and, most recently, COVID-19 in humans. But viruses can do more than elicit sickness -- and not all viruses are tiny.

19 Nov 2020

Study shows CRISPR/Cas9 system can effectively treat metastatic cancers

Researchers have shown that the advanced CRISPR/Cas9 system is extremely effective in curing metastatic cancers.

19 Nov 2020

Study outlines transient prospective stages in development of neural crest cells

Last year, researchers at the University of California, Riverside, identified the early origins of neural crest cells -- embryonic cells in vertebrates that travel throughout the body and generate many cell types -- in chick embryos.

19 Nov 2020

Somatic mutation acts as natural gene therapy in patients with GATA2 deficiency

Researchers affiliated with the Center for Cell-Based Therapy (CTC) in Ribeirão Preto, Brazil, have identified for the first time a non-hereditary mutation in blood cells from a patient with GATA2 deficiency, a rare autosomal disease caused by inherited mutations in the gene that encodes GATA-binding protein 2 (GATA2).

18 Nov 2020

Study finds that cannabidiol induces the expression of heme oxygenase 1 in skin cells

At present, cannabidiol has found considerable use not just in the world of cosmetics but also in nutrition and pharmaceutics due to its therapeutic potential.

17 Nov 2020

Study detects changes in how diseased neurons sense and use oxygen

Scientists have devised a new method for isolating a kind of brain cell that is related to symptoms of Parkinson’s disease.

17 Nov 2020

Salk’s HPI receives $30 million from Bezos Earth Fund to fight climate change

Salk's Harnessing Plants Initiative will receive $30 million from the Bezos Earth Fund to advance efforts to increase the ability of crop plants, such as corn and soybeans, to capture and store atmospheric carbon via their roots in the soil.

17 Nov 2020

Unique experiment shows how corals manage deoxygenation stress

Oxygen is life, in or out of the water, raising concerns that declining ocean oxygen stores are adding an additional environmental stress to already highly vulnerable coral reef ecosystems.

17 Nov 2020

New research uncovers vital link in complex biochemical pathway for saponin synthesis

Many plants, including legumes, make naturally occurring chemicals called saponins. For example, the medicinal plant licorice produces the saponin glycyrrhizin, a potent natural sweetener that also has antiviral and other pharmacological activity. Soyasaponins, found in soybeans, have anticarcinogenic and antioxidant properties.

From Osaka University 17 Nov 2020

Genes News and Research

Novel targeted therapy blocks critical metabolic pathways in cancer cells

Scientists use new technology to observe DNA defects in children with Fanconi anemia

Researchers use metal-organic frameworks to target prostate cancer cells

Architecture of cell nucleus can change gene activity in plants

First functional analysis of cytokine IL-15L using rainbow trout

Scientists discover how abnormal proteins unleash latent toxicity in neurodegenerative diseases

Gaining new insights into bacterial pneumonia

Scientists discover new functions of key cellular machine involved in human cancers

Endogenous viral elements play important role in genome evolution of green algae

Study shows CRISPR/Cas9 system can effectively treat metastatic cancers

Study outlines transient prospective stages in development of neural crest cells

Somatic mutation acts as natural gene therapy in patients with GATA2 deficiency

Study finds that cannabidiol induces the expression of heme oxygenase 1 in skin cells

Study detects changes in how diseased neurons sense and use oxygen

Salk’s HPI receives $30 million from Bezos Earth Fund to fight climate change

Unique experiment shows how corals manage deoxygenation stress

New research uncovers vital link in complex biochemical pathway for saponin synthesis

Light-activated liposomes could help deliver CRISPR gene therapy

Gene bank materials can be used to improve climate traits in plants

New approach can prevent toxicity linked to neurological gene therapy

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