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DNA methylation for precise gene expression regulation

If the genome is viewed as a guidebook for how a cell should operate, then annotations, highlights, and bookmarks are included on every page.

21 Feb 2023

New biomarker helps identify biological age

Once considered to be incompetent in encoding proteins due to their simple monotonous DNA repetitions, tiny telomeres at the tips of human chromosomes now appear to have a powerful biological function that could help better understand cancer and aging.

21 Feb 2023

Realistic model explores new treatments for brain tumors

Until now, the use of models to study the barrier that differentiates the circulatory and nervous systems has been either limited or extremely complex. ETH Zurich researchers have created a more accurate model that can also be used to effectively investigate new treatments for brain tumors.

21 Feb 2023

Novel metabolic pathway that makes immunology more efficient revealed

The metabolic pathways that produce a specific type of T cell are distinct from previously assumed, according to findings from the University of Michigan Rogel Cancer Center.

21 Feb 2023

Accelerating the structure-guided discovery of chemogenetic tools

In order to more fully understand how diseases arise in the brain, scientists must unravel the intricate way neurons relay messages (either chemical or electrical) along a complex web of nerve cells. One way is by using a tool called DREADDs, which stands for Designer Receptors Activated by Designer Drugs.

21 Feb 2023

Probiotic application shown to promote health and growth of piglets

This study is led by Prof. Heping Zhang (Inner Mongolia Key Laboratory of Dairy Biotechnology and Engineering, Inner Mongolia Agricultural University).

20 Feb 2023

Human sleep architecture varies substantially across seasons, study shows

Whether we're night owls or morning larks, our body clocks are set by the sun. Theoretically, changing day length and light exposure over the course of the year could affect the duration and quality of our sleep.

20 Feb 2023

Role of probiotics and functional materials in the treatment of intestinal inflammation

Maintenance of sulfomucin is a key end point in the treatment of diarrhea and inflammatory bowel disease (IBD). However, the mechanism underlying the microbial sense to sulfomucin are poorly understood, and to date, there are no therapies targeting the secretion and maturation of sulfomucin in IBD. Considering the important role of gut microbiota in host immune regulation, maintain sulfomucin by modulating the gut microbiota is inspired.

20 Feb 2023

Revealing a novel form of ferroptosis that may be implicated in diseases caused by acute injury

This study is led by Dr. Anjian Xu (Beijing Clinical Research Institute, Beijing Friendship Hospital, Capital Medical University), Dr. Min Cong (Liver Research Center, Beijing Friendship Hospital, Capital Medical University) and Dr. Junying Ding (Beijing Key Laboratory of Basic Research with Traditional Chinese Medicine on Infectious Diseases, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University).

20 Feb 2023

LLNL set off to develop vaccines to treat rheumatoid arthritis and lupus

People afflicted with autoimmune diseases may someday receive help through treatments now under development by a Lawrence Livermore National Laboratory (LLNL) licensee and its' collaborations with two major pharmaceutical companies.

19 Feb 2023

Location is the key for psychedelic drugs to work

Location, location, location is the key for psychedelic drugs that could treat mental illness by rapidly rebuilding connections between nerve cells.

17 Feb 2023

Extended generation of blood cells in wild-type animals from pluripotent stem cells

Cells present in the blood like red blood cells, immune cells, and other crucial cell types are renewed continually from stem cells, the alleged hematopoietic stem and progenitor cells (HSPCs).

17 Feb 2023

Developing a potential drug molecule that targets STAT5

STAT5 has generally been recognized as an enticing cancer target, but after years of research, it was downgraded to the “undruggable” category. Now, scientists at the University of Michigan Rogel Cancer Center have achieved success with a novel approach.

17 Feb 2023

Study identifies cell type crucial for successful immunotherapies for chronic viral infections

An international study led by researchers from the Infection Biology Laboratory at the UPF Department of Medicine and Life Sciences (MELIS) establishes that one type of dendritic cells is crucial for the success of immunotherapeutic treatments to control chronic viral infections.

17 Feb 2023

Digital microfluidics as the optimal technology for bacterial protocol advances

The February 2023 issue of SLAS Technology contains a set of four original research articles and one review article covering digital microfluidics (DMF), cryopreservation, colorectal cancer research and other laboratory automation technology.

17 Feb 2023

Researchers reveal link immune system genetics and a person's ability to resist new COVID-19 variants

An international team including researchers from the HSE University Faculty of Biology and Biotechnology has found a link between certain genetic features of the immune system and one's ability to effectively resist new waves of COVID-19.

17 Feb 2023

LJI receives funding from NIAID to lead the biggest human immunoprofiling effort

A new grant of over $17 million from the National Institute of Allergy and Infectious Diseases (NIAID) has established La Jolla Institute for Immunology (LJI) as the leading institute for human immunology data curation, analysis, and dissemination. With this funding, LJI has taken the helm of the Human Immunology Project Consortium Data Coordinating Center, a critical tool in the effort to fuel scientific collaboration in immunoprofiling and highlight findings from the overall Human Immunology Project Consortium (HIPC).

16 Feb 2023

Baby kangaroo feces may offer a solution to reduce methane emissions from cattle

Baby kangaroo feces might help provide an unlikely solution to the environmental problem of cow-produced methane.

15 Feb 2023

Pungent ginger constituent puts white blood cells on heightened alert

Ginger has a reputation for stimulating the immune system. New results from the Leibniz Institute for Food Systems Biology at the Technical University of Munich (Leibniz-LSB@TUM) now support this thesis.

15 Feb 2023

IGSF3-mediated potassium dysregulation drives glioma-related epilepsy

Glioma is one of the most aggressive malignant primary brain tumors. A common feature of glioma is the presence of localized, intermittent seizures referred to as glioma-related epilepsy, which is known to promote tumor growth. However, the mechanism involved at the molecular level is still not clear.

15 Feb 2023

Laboratory News and Research

DNA methylation for precise gene expression regulation

New biomarker helps identify biological age

Realistic model explores new treatments for brain tumors

Novel metabolic pathway that makes immunology more efficient revealed

Accelerating the structure-guided discovery of chemogenetic tools

Probiotic application shown to promote health and growth of piglets

Human sleep architecture varies substantially across seasons, study shows

Role of probiotics and functional materials in the treatment of intestinal inflammation

Revealing a novel form of ferroptosis that may be implicated in diseases caused by acute injury

LLNL set off to develop vaccines to treat rheumatoid arthritis and lupus

Location is the key for psychedelic drugs to work

Extended generation of blood cells in wild-type animals from pluripotent stem cells

Developing a potential drug molecule that targets STAT5

Study identifies cell type crucial for successful immunotherapies for chronic viral infections

Digital microfluidics as the optimal technology for bacterial protocol advances

Researchers reveal link immune system genetics and a person's ability to resist new COVID-19 variants

LJI receives funding from NIAID to lead the biggest human immunoprofiling effort

Baby kangaroo feces may offer a solution to reduce methane emissions from cattle

Pungent ginger constituent puts white blood cells on heightened alert

IGSF3-mediated potassium dysregulation drives glioma-related epilepsy

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