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Mismatch Repair Genes Found to be Key Drivers of Huntington's Disease

A new UCLA Health study has discovered in mouse models that genes associated with repairing mismatched DNA are critical in eliciting damages to neurons that are most vulnerable in Huntington's disease and triggering downstream pathologies and motor impairment, shedding light on disease mechanisms and potential new ways to develop therapies.

12 Feb 2025

Single-Cell Analysis Reveals Critical Kidney Cell Types Involved in Disease

Researchers at the University of Pennsylvania's Perelman School of Medicine have published a new study in the journal Science that suggests over 1,000 genes could be potential targets for kidney disease treatment.

12 Feb 2025

Understanding Plant Repair of Light-Damaged Photosystems

More than two billion years ago, cyanobacteria started to produce oxygen in the primarily toxic atmosphere of Earth.

11 Feb 2025

New Study Reveals Energy-Saving Strategies in Neuronal Protein Synthesis

Nerve cells use incredible energy-saving techniques while still carrying out their primary functions.

10 Feb 2025

Researchers Unveil Mechanisms Behind Neural Stem Cell Activation and Quiescence

A University of Ottawa neuroscientist has led a Canadian research team to reveal important new insights into the activation dynamics of neural stem cells (NSCs).

8 Feb 2025

New Brain Cells Could Hold the Key to Regulating Satiation

Columbia scientists have found specialized neurons in the brains of mice that order the animals to stop eating.

6 Feb 2025

The Cost of Being King: Alpha Baboons Trade Power for Survival

Research on male baboons reveals that alpha males face higher energetic costs and chronic stress, challenging assumptions about dominance and well-being.

3 Feb 2025

Novel Chemo-Optogenetic Systems Offer Spatiotemporal Precision

A research team at Umeå University has created advanced light-controlled tools that allow for precise regulation of proteins in real time within living cells.

31 Jan 2025

EpiBERT AI Model Reveals How Genes Are Regulated in Human Cells

A team of investigators from Dana-Farber Cancer Institute, The Broad Institute of MIT and Harvard, Google, and Columbia University have created an artificial intelligence model that can predict which genes are expressed in any type of human cell.

30 Jan 2025

Temperature-Sensitive Protein Enables Non-Invasive Control of Cellular Behavior

Imagine being at a big marquee event at an arena, like the Super Bowl, with the roar of the crowd, the smell of hot dogs, and a sea of jerseys all merging into one chaotic blur.

30 Jan 2025

Fast and Precise Protein Labeling in Intact Tissues with MIT Technology

A new technology developed at MIT enables scientists to label proteins across millions of individual cells in fully intact 3D tissues with unprecedented speed, uniformity, and versatility.

27 Jan 2025

Mapping the Human Virome to Uncover Links Between Viruses and Health

You, my friend, are what scientists call a "holobiont"- an organism made up of human cells and the multiplicity of microscopic species living inside you and on your body.

27 Jan 2025

Genome Dynamics Reveals the Keys to Long-Term Survival in an Asexual Mite

An international group of researchers at the University of Cologne have explored the asexual reproduction of oribatid mites using genome sequencing methods.

27 Jan 2025

Study Reveals How Male Ruff Birds Use a "Super Enzyme" to Tame Excess Testosterone

We normally associate high testosterone levels with male dominance and aggression. Among ruffs – a shore bird that breeds across Europe and Asia – some males suffer from too much of it.

24 Jan 2025

New Research Sheds Light on Y Chromosome’s Role in Male Infertility

Researchers at the Crick have uncovered which genes on the Y chromosome regulate the development of sperm and impact fertility in male mice.

24 Jan 2025

New Method Enables 20 Color Bioluminescent Imaging for Live Cells

Imaging live cells with fluorescent proteins has long been a crucial technique for understanding cellular behavior. While bioluminescent proteins offer several advantages over fluorescent proteins, the limited availability of color variants has made it difficult to observe multiple targets simultaneously.

23 Jan 2025

Genetic Mutations May Be Behind Epigenetic Clock of Aging

Researchers at University of California San Diego School of Medicine have published results that shed new light on an old question: what causes aging at the molecular level? Their findings, published in Nature Aging, describe a never-before-seen link between the two most accepted explanations: random genetic mutations and predictable epigenetic modifications.

22 Jan 2025

Mapping Global Microbial Diversity Using Genomic Sequencing Data

Metagenomic datasets could help map out microbial diversity hotspots. Published January 17, 2025 in Science Advances, researchers at the U.S. Department of Energy (DOE) Joint Genome Institute (JGI), a DOE Office of Science User Facility located at Berkeley Laboratory, have taken stock of the current state of microbial genomic biodiversity.

20 Jan 2025

Deep Sea Foraminifera Species Unveil Secrets of Life in Extreme Environments

Most life on Earth relies on the sun's energy for survival, but what about organisms in the deep sea that live beyond the reach of its rays? A new study led by Woods Hole Oceanographic Institution (WHOI), published in The ISME Journal, sheds light on how a species of foraminifera, single-celled organisms found in almost all marine habitats, thrives in a dark, oxygen-free environment.

17 Jan 2025

New study reveals how genes switch on and off in human cells

An international group of scientists has made a significant advancement in their understanding of the regulation of gene expression throughout the human genome.

17 Jan 2025