Liver Disease News and Research

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The liver is one of the largest solid organs of the body. It is located in the upper right part of the abdomen. Most of the organ lies under cover of the rib cage.

Researchers employ hepatic organoids for disease modeling

Associate Professor Tamer Önder created and analyzed the hepatic organoid culture system utilizing human induced pluripotent stem cell as an intermediate.

8 Nov 2021

Brown fat protects against secondary obesity-related diseases, says study

Research demonstrated that obese individuals with active brown fat possess a healthier metabolism and utilize more energy than obese people without.

8 Nov 2021

Study identifies DNA mutations that impact metabolism and insulin sensitivity in liver disease patients

For the first time, DNA mutations in liver cells have been identified that impact metabolism and insulin sensitivity in patients with liver disease.

15 Oct 2021

Oral diuretic pill may potentially be repurposed to treat Alzheimer's in people with genetic risk

A commonly available oral diuretic pill approved by the U.S. Food and Drug Administration may be a potential candidate for an Alzheimer's disease treatment for those who are at genetic risk, according to findings published in Nature Aging.

12 Oct 2021

Potential biomarkers help diagnose progressive stages of liver disease

Results of national research pinpointed potential biomarkers that could ultimately be employed for the diagnosis of progressive stages of liver disease.

23 Sep 2021

Study analyzes the health benefits of time-restricted eating

Time-restricted eating (TRE) is a dietary regimen in which eating is restricted to particular hours. It has received great attention in weight-loss circles.

19 Aug 2021

Modification in some RNA molecules could protect against non-alcoholic fatty liver

RNA molecules while carrying genetic instructions from DNA to the protein-making machinery of cells could help guard against non-alcoholic fatty liver.

21 Jul 2021

Liver fibrosis might be treatable with selective immunotoxins

Chronic alcohol abuse and hepatitis can injure the liver and lead to fibrosis, the buildup of collagen and scar tissue. As a potential approach to treating liver fibrosis, University of California San Diego School of Medicine researchers and their collaborators are looking for ways to stop liver cells from producing collagen.

13 Jul 2021

Lipidomics study reveals schizophrenic patients’ resistance to antipsychotic drugs

Scientists discovered 22 lipids in the blood plasma of schizophrenia patients that were linked to slower symptom improvement over time.

8 Jul 2021

New method for generating metabolic profiles of individual cells

Researchers from the EMBL and the German Cancer Research Center (DKFZ) demonstrated a new technique to create metabolic profiles of individual cells.

8 Jul 2021

Diet plays a crucial role in liver disease outcome, mouse model shows

Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide. NAFLD patients are at higher risk of developing Non-alcoholic steatohepatitis (NASH), which causes severe and chronic liver inflammation, fibrosis and liver damage.

2 Jun 2021

High-fat, high-sugar diet reduces intestinal immune cell activity in mice

A team of researchers led by Thaddeus Stappenbeck discovered that a high-fat, high-sugar diet relates to reduced intestinal immune cell activity in mice.

20 May 2021

Disease-driving B cells play a role in non-alcoholic fatty liver disease

A study by researchers proposes that disease-driving B cells—a kind of white blood cell—have a role in the development of non-alcoholic fatty liver disease.

23 Mar 2021

Using genetic engineering to grow synthetic livers

News-Medical talks to Dr. Mo Ebrahimkhani about his research using genetic engineering together with a machine-learning algorithm to mature a lab-grown 'designer liver organoid'.

From University of Pittsburgh 15 Dec 2020

Research shows lipogenesis process is dysregulated in obesity, fatty liver disease

The production of fat in the human body is essentially regulated by gut hormones.

25 Nov 2020

Dietary supplement helps to partially prevent fatty liver disease in rats

A recent study by researchers at the University of Jyväskylä was successful in partially preventing fatty liver disease in rats.

5 Nov 2020

Reducing food intake can reduce risk of liver cancer caused by fatty liver

Liver cancer from too much fat accumulation in the liver has been increasing in many countries including Japan. In order to change this unfortunate state of affairs, it is important to improve the prognosis of non-alcoholic fatty liver disease.

2 Nov 2020

Study identifies genes and molecular pathways most sensitive to chemical exposures

A University of Massachusetts Amherst environmental health scientist has used an unprecedented objective approach to identify which molecular mechanisms in mammals are the most sensitive to chemical exposures.

30 Oct 2020

Ketogenic diets can prevent or reverse heart failure caused by metabolic process

Research from Saint Louis University finds that high fat or "ketogenic" diets could completely prevent, or even reverse heart failure caused by a metabolic process.

27 Oct 2020

Researchers uncover a new cellular mechanism for disposing of misfolded proteins

About 30 years ago, Dr. Richard Sifers set out on a journey to discover why people with a rare condition known as alpha1-antitrypsin (AAT) deficiency present with high variation in the severity of liver disease.

21 Oct 2020