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Genes could help determine the intensity of neutralizing antibodies to COVID-19 virus

While neutralizing antibodies form in less than two weeks of a COVID-19 infection, their intensity and durability can differ from one individual to another.

22 Feb 2021

First-in-human clinical trial to test safety, efficacy of gene therapy for Alzheimer's disease

Researchers at University of California San Diego School of Medicine have launched a first-in-human Phase I clinical trial to assess the safety and efficacy of a gene therapy to deliver a key protein into the brains of persons with Alzheimer's disease (AD) or Mild Cognitive Impairment (MCI), a condition that often precedes full-blown dementia.

From UC San Diego 19 Feb 2021

Cryogenic electron microscopy reveals shape of glutamate transporters involved in neurological diseases

An international research team has uncovered the shape of the glutamate transporter and helps explain how the human brain cells interact with each other.

18 Feb 2021

Study identifies how CTLA-4 blockade can disable suppressive immune cells to aid tumor destruction

A Ludwig Cancer Research study has identified a novel mechanism by which a type of cancer immunotherapy known as CTLA-4 blockade can disable suppressive immune cells to aid the destruction of certain tumors.

18 Feb 2021

Research links blood-clotting protein with CNS B-cell lymphoma growth

In people with central nervous system (CNS) lymphoma, cancerous B cells--a type of white blood cell--accumulate to form tumors in the brain or spinal cord, often in close proximity to blood vessels.

18 Feb 2021

Testing for inherited genes can help understand future cancer risk in pediatric patients

Because cancers in children are rare, many details about their biology remain unknown. In the field of cancer genetics, there's a limited understanding of how inherited genetic changes may contribute to the formation and growth of tumors.

17 Feb 2021

Study suggests a way to improve immunotherapy by altering immune cells’ access to sugar

Cancer cells and immune cells share something in common: They both love sugar. Sugar is an important nutrient. All cells use sugar as a vital source of energy and building blocks. For immune cells, gobbling up sugar is a good thing, since it means getting enough nutrients to grow and divide for stronger immune responses. But cancer cells use sugar for more nefarious ends.

17 Feb 2021

Combining cholesterol-lowering medications and lifestyle interventions may yield better benefits

Combining healthy lifestyle interventions reduces heart disease through beneficial effects on different lipoproteins and associated cholesterols, according to a study published February 9 in eLife.

17 Feb 2021

Gut microbiome alterations help melanoma patients to respond to immunotherapy

Statistical modeling developed by Oregon State University researchers has confirmed that changes to melanoma patients' gut microbiome led them to respond to a type of treatment capable of providing long-term benefit.

17 Feb 2021

Genetic testing technology is extremely unreliable in detecting very rare genetic variants

According to a new study, a technology that is extensively used by commercial genetic testing firms is “extremely unreliable” in identifying very rare variants.

From University of Exeter 16 Feb 2021

Tumor microenvironment could improve cancer immunotherapy

A study has revealed how chemicals surrounding tumors, the tumor microenvironment, undermine the immune system and allow cancer to resist attack.

From University of Pittsburgh 16 Feb 2021

New understanding of tumor microenvironment could help enhance immunotherapy

A paper published today in Nature shows how chemicals in the areas surrounding tumors--known as the tumor microenvironment--subvert the immune system and enable cancer to evade attack. These findings suggest that an existing drug could boost cancer immunotherapy.

From University of Pittsburgh 16 Feb 2021

Gene-based blood test may predict treatment success in people with metastatic melanoma

A test that monitors blood levels of DNA fragments released by dying tumor cells may serve as an accurate early indicator of treatment success in people in late stages of one of the most aggressive forms of skin cancer, a new study finds.

From New York University (NYU) 15 Feb 2021

Animal model yields important insights into T cell exhaustion

T lymphocytes, or T cells, are an important component of our immune system. They can recognize foreign proteins, so-called antigens, as peptide fragments - for instance, those derived from viruses or cancer cells.

15 Feb 2021

Electrochemical sensor for rapid detection of multiple sepsis biomarkers in whole blood

Many life-threatening medical conditions, such as sepsis, which is triggered by blood-borne pathogens, cannot be detected accurately and quickly enough to initiate the right course of treatment.

15 Feb 2021

Study reveals a new role of SRC-3 protein in various cancers

New research has revealed a new role of the steroid receptor coactivator 3, also called SRC-3/NCOA3.

15 Feb 2021

Tiny population of neurons may play a significant role in depression

A tiny population of neurons known to be important to appetite appear to also have a significant role in depression that results from unpredictable, chronic stress, scientists say.

12 Feb 2021

Genomic test helps identify prostate cancer patients who may benefit from hormone therapy

A commercially available genomic test may help oncologists better determine which patients with recurrent prostate cancer may benefit from hormone therapy, according to new research from the Johns Hopkins Kimmel Cancer Center and 15 other medical centers.

12 Feb 2021

New way to quantify the key characteristics of RNA-binding proteins

A research team from Case Western Reserve University has discovered a new way to quantify the main characteristics of proteins that bind to RNA in cells—a finding that may enhance one’s interpretation of how gene regulation is disrupted in infections, neurodegenerative diseases, or cancer.

11 Feb 2021

Daytime napping is partly regulated by a person's genes

How often a person takes daytime naps, if at all, is partly regulated by their genes, according to new research led by investigators at Massachusetts General Hospital (MGH) and published in Nature Communications.

11 Feb 2021

Medicine News and Research

Genes could help determine the intensity of neutralizing antibodies to COVID-19 virus

First-in-human clinical trial to test safety, efficacy of gene therapy for Alzheimer's disease

Cryogenic electron microscopy reveals shape of glutamate transporters involved in neurological diseases

Study identifies how CTLA-4 blockade can disable suppressive immune cells to aid tumor destruction

Research links blood-clotting protein with CNS B-cell lymphoma growth

Testing for inherited genes can help understand future cancer risk in pediatric patients

Study suggests a way to improve immunotherapy by altering immune cells’ access to sugar

Combining cholesterol-lowering medications and lifestyle interventions may yield better benefits

Gut microbiome alterations help melanoma patients to respond to immunotherapy

Genetic testing technology is extremely unreliable in detecting very rare genetic variants

Tumor microenvironment could improve cancer immunotherapy

New understanding of tumor microenvironment could help enhance immunotherapy

Gene-based blood test may predict treatment success in people with metastatic melanoma

Animal model yields important insights into T cell exhaustion

Electrochemical sensor for rapid detection of multiple sepsis biomarkers in whole blood

Study reveals a new role of SRC-3 protein in various cancers

Tiny population of neurons may play a significant role in depression

Genomic test helps identify prostate cancer patients who may benefit from hormone therapy

New way to quantify the key characteristics of RNA-binding proteins

Daytime napping is partly regulated by a person's genes

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