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Researchers sequence 64 human genomes at high resolution

After the successful conclusion of the “Human Genome Project”, an international research team has sequenced a total of 64 human genomes at high resolution.

26 Feb 2021

Genes inherited from parents are responsible for severe COVID-19

For the first time, scientists have discovered the genetic predisposition of severe COVID-19 disease.

24 Feb 2021

Researchers identify a type of RNA as therapeutic target for Huntington's treatment

Huntington's disease is caused by a mutation in the Huntingtin gene (HTT), which appears in adults and features motor, cognitive and psychiatric alterations.

24 Feb 2021

Interbacterial toxins may contribute to bacterial genetic diversity

A toxin produced by bacteria as a defense mechanism causes mutations in target bacteria that could help them survive, according to a study published today in eLife.

24 Feb 2021

First-in-human clinical trial to test safety, efficacy of gene therapy for Alzheimer's disease

Researchers at University of California San Diego School of Medicine have launched a first-in-human Phase I clinical trial to assess the safety and efficacy of a gene therapy to deliver a key protein into the brains of persons with Alzheimer's disease (AD) or Mild Cognitive Impairment (MCI), a condition that often precedes full-blown dementia.

From UC San Diego 19 Feb 2021

Almost one in five people lack key protein in their muscle fibers

About one in five individuals do not have the α-actinin-3 protein in their muscle fiber.

18 Feb 2021

Testing for inherited genes can help understand future cancer risk in pediatric patients

Because cancers in children are rare, many details about their biology remain unknown. In the field of cancer genetics, there's a limited understanding of how inherited genetic changes may contribute to the formation and growth of tumors.

17 Feb 2021

Researchers use zebrafish to identify role of gene involved in cardiac rhythm

Researchers have used the zebrafish (Danio rerio) to identify the role of a gene involved in cardiac rhythm, which could help explain the fundamentals of what it takes to make a human heartbeat.

17 Feb 2021

Gene-based blood test may predict treatment success in people with metastatic melanoma

A test that monitors blood levels of DNA fragments released by dying tumor cells may serve as an accurate early indicator of treatment success in people in late stages of one of the most aggressive forms of skin cancer, a new study finds.

From New York University (NYU) 15 Feb 2021

Innovative system allows complete study of SARS-CoV-2 mutant spectrum by ultrasequencing

Researchers have designed a program that allows the complete study of the SARS-CoV-2 mutant spectrum by ultrasequencing.

15 Feb 2021

N-terminal acetylation shields proteins from degradation and inhibits programmed cell death

A new study shows that proteins called IAPs, which can trigger programmed cell death, are inhibited by a specific chemical modification, and reveals that they play a wider role in protein quality control than previously assumed.

11 Feb 2021

Unusual DNA folding leads to higher mutation rates

DNA sequences that can fold into shapes other than the classic double helix tend to have higher mutation rates than other regions in the human genome.

From Penn State University 10 Feb 2021

New platform may accelerate genomic medicine research, drug therapies

A research team, headed by Cleveland Clinic, has designed a novel personalized genomic medicine platform that would help speed up genomic medicine studies as well as genome-informed drug discovery. The results of the new study have been recently published in the Genome Biology journal.

9 Feb 2021

Hidden genes in bacteriophages may be key to the development of new antibiotics

A study from the Center for Phage Technology, part of Texas A&M's College of Agriculture and Life Sciences and Texas A&M AgriLife Research, shows how the "hidden" genes in bacteriophages -- types of viruses that infect and destroy bacteria -- may be key to the development of a new class of antibiotics for human health.

8 Feb 2021

Study shows how microbiomes may recover from biodiversity loss

For many years, researchers have fought with opposing theories to describe how inter-species interactions, including competition, affect biodiversity.

5 Feb 2021

Genetic burden of retrogene mutations is greater than originally believed

According to a new study performed by researchers from the Max Planck Institute for Evolutionary Biology in Plön, Germany, and the Chinese Academy of Sciences in Beijing, the possible genetic burden of mutations emerging from retrogenes is considerably greater than originally believed.

3 Feb 2021

Scientists discover the origin of rare genetic syndrome

Improvements in DNA sequencing have revealed a rare syndrome triggered by changes in the SATB1gene.

29 Jan 2021

Genetic changes in tumors could help predict patient's response to immunotherapy drugs

Researchers at the Francis Crick Institute, the UCL Cancer Institute, and the Cancer Research UK Lung Cancer Centre of Excellence have identified genetic changes in tumours which could be used to predict if immunotherapy drugs would be effective in individual patients.

28 Jan 2021

New variant of CRISPR-Cas9 tool expands genomic editing in plants

For the first time, Yiping Qi has represented the College of Agriculture & Natural Resources on the Web of Science 2020 list of Highly Cited Researchers.

26 Jan 2021

Cancer cells can exchange and recombine their genetic material, shows study

Evolution within groups of tumor cells follows the principles of natural selection, as evolution in pathogenic microbes.

22 Jan 2021

Mutation News and Research

Researchers sequence 64 human genomes at high resolution

Genes inherited from parents are responsible for severe COVID-19

Researchers identify a type of RNA as therapeutic target for Huntington's treatment

Interbacterial toxins may contribute to bacterial genetic diversity

First-in-human clinical trial to test safety, efficacy of gene therapy for Alzheimer's disease

Almost one in five people lack key protein in their muscle fibers

Testing for inherited genes can help understand future cancer risk in pediatric patients

Researchers use zebrafish to identify role of gene involved in cardiac rhythm

Gene-based blood test may predict treatment success in people with metastatic melanoma

Innovative system allows complete study of SARS-CoV-2 mutant spectrum by ultrasequencing

N-terminal acetylation shields proteins from degradation and inhibits programmed cell death

Unusual DNA folding leads to higher mutation rates

New platform may accelerate genomic medicine research, drug therapies

Hidden genes in bacteriophages may be key to the development of new antibiotics

Study shows how microbiomes may recover from biodiversity loss

Genetic burden of retrogene mutations is greater than originally believed

Scientists discover the origin of rare genetic syndrome

Genetic changes in tumors could help predict patient's response to immunotherapy drugs

New variant of CRISPR-Cas9 tool expands genomic editing in plants

Cancer cells can exchange and recombine their genetic material, shows study

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