Oligonucleotides News and Research

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Oligonucleotides are short sequences of nucleotides (RNA or DNA), typically with twenty or fewer bases. Automated synthesizers allow the synthesis of oligonucleotides up to 160 to 200 bases.

New Delivery System Opens the Door to Gene-Silencing Therapy

The next generation of medications, known as antisense oligonucleotides (ASOs), works by preventing the transmission of damaging genetic messages.

16 Apr 2024

Researchers Create Groundbreaking RNA and DNA Solutions to Shield Plants from Viral Attacks

Customized RNA or DNA molecules have been shown to effectively combat viral infections in plants, as demonstrated in a recent study conducted by Martin Luther University Halle-Wittenberg (MLU) and published in the International Journal of Molecular Sciences.

1 Mar 2024

Intellegens and CPI Awarded £1.6 m Innovate UK Grant to Advance Manufacture of Oligonucleotide Therapeutics with Machine Learning

Intellegens today announced that it has secured a £1.6 m grant from Innovate UK, part of UK Research and Innovation (UKRI), to apply ML in the emerging field of oligonucleotide therapies.

From Intellegens Limited 30 Aug 2023

Targeting Long-read RNA Sequencing with Low-Cost Technology

Researchers at the Children’s Hospital of Philadelphia (CHOP) have created a flexible and affordable approach for targeted sequencing of full-length RNA molecules, which might hasten the development of novel diagnostics and therapies.

16 Aug 2023

Review: Role of Alternative Splicing Defects in Major Neurodegenerative Diseases

Alternative splicing, a clever way a cell generates many different variations of messenger RNAs -; single-stranded RNAs involved in protein synthesis -; and proteins from the same stretch of DNA, plays an important role in molecular biology.

21 Jun 2023

Predictive Models to Determine the Structure, Stability, Flexibility and Biology of RNA-Targeted Drugs

Proteins are large, complex molecules that play many critical roles in the body and are produced following the instructions encoded in DNA.

18 May 2023

Eliminating or Blocking the Tiam1 Gene Prevents, Reverses Chronic Neuropathic Pain

Neuropathy is a type of chronic pain triggered by nerve injury or certain diseases. It affects millions of people worldwide, significantly deteriorating their quality of life.

5 May 2023

Potential Therapy for Lethal Pediatric Brain Cancer Using ASO Technology

Diffuse intrinsic pontine glioma (DIPG) is a lethal pediatric brain cancer that often kills within a year of diagnosis. Surgery is almost impossible because of the tumors' location.

13 Apr 2023

DNA drugs help restore the normal processing of protein-encoding RNA

A protein named TDP-43 has been lost from its normal location in the nucleus of the cell in virtually all persons having amyotrophic lateral sclerosis (ALS) and in up to half of all cases of frontotemporal dementia and Alzheimer’s disease (AD).

From UC San Diego 20 Mar 2023

Delaying paralysis in ALS by using designer DNA drug

In virtually all persons with amyotrophic lateral sclerosis (ALS) and in up to half of all cases of Alzheimer's disease (AD) and frontotemporal dementia, a protein called TDP-43 is lost from its normal location in the nucleus of the cell.

20 Mar 2023

Effective and faster methodology detects RNA viruses based on the triplex-forming probe technology

Experts from the University of Barcelona, the Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), the Institute of Microelectronics of Barcelona (IMB-CNM-CSIC) and the Aragon Nanoscience and Materials Institute of Aragon (INMA) -;a joint institute of the CSIC and the University of Zaragoza-; have developed a new method to detect RNA viruses based on the triplex-forming probe technology.

28 Feb 2023

Adaptation to climate change in plants aided by epigenetic memories

Animals are able to quickly adapt to changing environmental conditions and survive. There is growing evidence that plants can, too.

21 Nov 2022

New computer model helps identify mutations that drive tumor growth

Cancer cells can have thousands of mutations in their DNA. However, only a handful of those actually drive the progression of cancer; the rest are just along for the ride.

22 Jun 2022

Researchers introduce CRISPR to enable gene editing in cockroaches

According to a study released by Cell Press on May 16th, 2022, in the journal Cell Reports Methods, scientists have created a CRISPR-Cas9 technique to facilitate gene editing in cockroaches.

23 May 2022

Study identifies new therapy to treat cystic fibrosis

The process of making proteins from genes is similar to that of a factory, where employees must follow a set of instructions that are both effective and precise.

31 Jan 2022

Aptamers for Targeting SARS-CoV-2 Proteins

AMSBIO has further expanded its product range to help in the fight against COVID-19 with the introduction of a new range of aptamers targeting SARS-CoV-2 proteins to aid development of new kits and assays.

From AMS Biotechnology 15 Sep 2021

Researchers uncover cellular mechanisms by which the silencing therapies act in cells

Gene silencing therapies are used to interfere with, or "silence", the expression of genes that are associated with disorders. Now, a team at TMDU has uncovered some of the cellular mechanisms by which the silencing therapies act in cells.

7 Jul 2021

An efficient automated method for production of synthetic DNA

Chemically synthesized short DNA sequences are extremely important ingredients with countless uses in research laboratories, hospitals, and in industry, like in the method for identifying COVID-19.

13 May 2021

New highly sensitive RNA detection method advances in situ transcriptomics

Human cells typically transcribe half of their roughly 20,000 genes into RNA molecules at any given time. Just like with proteins, the function of those RNA species not only relies on their abundance but also their precise localization within the 3D space of each cell.

18 Mar 2021

Researchers demonstrate strategy to control chemical reactions using antibodies

Antibodies are remarkable biomarkers: they are the cues that provide us with indications about many diseases and how our immune system counter them. Now a group of scientists from the University of Rome, Tor Vergata (Italy) has found a way to repurpose them so that they can trigger a specific chemical reaction.

8 Dec 2020