Oligonucleotides News and Research

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Oligonucleotides are short sequences of nucleotides (RNA or DNA), typically with twenty or fewer bases. Automated synthesizers allow the synthesis of oligonucleotides up to 160 to 200 bases.
New Chemical Modification Enhances Antisense Oligonucleotide Targeting in CNS Diseases

New Chemical Modification Enhances Antisense Oligonucleotide Targeting in CNS Diseases

Glutamate tRNA Fragments Play Key Role in Brain Aging and Alzheimer's Disease

Glutamate tRNA Fragments Play Key Role in Brain Aging and Alzheimer's Disease

New Delivery System Opens the Door to Gene-Silencing Therapy

New Delivery System Opens the Door to Gene-Silencing Therapy

Researchers Create Groundbreaking RNA and DNA Solutions to Shield Plants from Viral Attacks

Researchers Create Groundbreaking RNA and DNA Solutions to Shield Plants from Viral Attacks

Intellegens and CPI Awarded £1.6 m Innovate UK Grant to Advance Manufacture of Oligonucleotide Therapeutics with Machine Learning

Intellegens and CPI Awarded £1.6 m Innovate UK Grant to Advance Manufacture of Oligonucleotide Therapeutics with Machine Learning

Targeting Long-read RNA Sequencing with Low-Cost Technology

Targeting Long-read RNA Sequencing with Low-Cost Technology

Review: Role of Alternative Splicing Defects in Major Neurodegenerative Diseases

Review: Role of Alternative Splicing Defects in Major Neurodegenerative Diseases

Predictive Models to Determine the Structure, Stability, Flexibility and Biology of RNA-Targeted Drugs

Predictive Models to Determine the Structure, Stability, Flexibility and Biology of RNA-Targeted Drugs

Eliminating or Blocking the Tiam1 Gene Prevents, Reverses Chronic Neuropathic Pain

Eliminating or Blocking the Tiam1 Gene Prevents, Reverses Chronic Neuropathic Pain

Potential Therapy for Lethal Pediatric Brain Cancer Using ASO Technology

Potential Therapy for Lethal Pediatric Brain Cancer Using ASO Technology

DNA drugs help restore the normal processing of protein-encoding RNA

DNA drugs help restore the normal processing of protein-encoding RNA

Delaying paralysis in ALS by using designer DNA drug

Delaying paralysis in ALS by using designer DNA drug

Effective and faster methodology detects RNA viruses based on the triplex-forming probe technology

Effective and faster methodology detects RNA viruses based on the triplex-forming probe technology

Adaptation to climate change in plants aided by epigenetic memories

Adaptation to climate change in plants aided by epigenetic memories

New computer model helps identify mutations that drive tumor growth

New computer model helps identify mutations that drive tumor growth

Researchers introduce CRISPR to enable gene editing in cockroaches

Researchers introduce CRISPR to enable gene editing in cockroaches

Study identifies new therapy to treat cystic fibrosis

Study identifies new therapy to treat cystic fibrosis

Aptamers for Targeting SARS-CoV-2 Proteins

Aptamers for Targeting SARS-CoV-2 Proteins

Researchers uncover cellular mechanisms by which the silencing therapies act in cells

Researchers uncover cellular mechanisms by which the silencing therapies act in cells

An efficient automated method for production of synthetic DNA

An efficient automated method for production of synthetic DNA

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