Organoids are three-dimensional cell cultures from embryonic stem cells or induced pluripotent stem cells that model important features of whole organs.
Researchers created organoids from cancer cells to reduce the need for trial and error in identifying effective cancer treatments in one of many cancer studies scheduled for presentation this week at Digestive Disease Week (DDW) 2023.
Scientists of the Princess Máxima Center for pediatric oncology and Hubrecht Institute in the Netherlands have revealed new scientific insights into the features of fibrolamellar carcinoma (FLC), a rare type of childhood liver cancer
Developing and testing new treatments or vaccines for humans almost always requires animal trials, but these experiments can sometimes take years to complete and can raise ethical concerns about the animals' treatment.
A new chip that holds different cell types in tiny, interconnected chambers could allow scientists to better understand the physiological and disease interactions between organs.
A team led by Masaya Hagiwara of RIKEN national science institute in Japan has developed an ingenious device, using layers of hydrogels in a cube-like structure, that allows researchers to construct complex 3D organoids without using elaborate techniques.
CrestOptics S.p.A., a manufacturer of high-end microscopy solutions and advanced systems for fluorescence microscopy and diagnostic applications, today announced the launch of its new spinning disk confocal microscope system, CICERO.
A National Eye Institute-led team has identified a compound already approved by the U.S. Food and Drug Administration that keeps light-sensitive photoreceptors alive in three models of Leber congenital amaurosis type 10 (LCA 10), an inherited retinal ciliopathy disease that often results in severe visual impairment or blindness in early childhood.
Bacteria have thousands of genes and functions that we, the human host, do not have. For instance, bacteria can help us digest fiber, provide support to our immune systems, and absorb important nutrients. But reaping the benefits of "good bacteria" is easier said than done.
Researchers have used pluripotent stem cells to make thymus organoids that support the development of patient-specific T-cells, researchers report March 23rd in the journal Stem Cell Reports.
Research in animal models has demonstrated that stem-cell derived heart tissues have promising potential for therapeutic applications to treat cardiac disease. But before such therapies are viable and safe for use in humans, scientists must first precisely understand on the cellular and molecular levels which factors are necessary for implanted stem-cell derived heart cells to properly grow and integrate in three dimensions within surrounding tissue.
According to Johns Hopkins University scientists, a “biocomputer” fueled by human brain cells could be created within this lifetime. Such technology is expected to tremendously enhance the capabilities of modern computing and develop novel fields of study.
Despite the fact that we all start out as an egg cell in one of our mother's ovaries, these human reproductive organs are surprisingly under-studied. Scientists have been working on creating in vitro models of human ovaries so that we can learn more about them and develop treatments for ovarian conditions, but most existing models use a combination of human and mouse cells, which do not faithfully replicate human ovary functions and take a long time to grow in the lab.
The February 2023 issue of SLAS Technology contains a set of four original research articles and one review article covering digital microfluidics (DMF), cryopreservation, colorectal cancer research and other laboratory automation technology.
Although it has long been believed that microRNA (miRNA) molecules in pancreatic islets play significant roles in Type 2 diabetes, no specific miRNAs have been definitively linked to the disease in humans.
Why are some people diagnosed with ADHD while others are not? And when is the seed of ADHD sown, in life or the womb?
In this interview, we speak with Laralynne Przybyla about how she is utilizing CRISPR platforms to understand human disease biology in greater detail.
Disabling hearing loss affects one in every ten people and up to 25% of people over 60, according to the World Health Organization, and can have both genetic and environmental causes such as infections and noise exposure.
At the NYU Langone Health’s Perlmutter Cancer Center, a team headed by scientists has determined a gene that forces the development of the second most common type of lung carcinoma.
Researchers at Johns Hopkins Medicine say they have created a laboratory-grown three-dimensional "organoid" model that is derived from human tissue and designed to advance understanding about how early stages of cancer develop at the gastroesophageal junction (GEJ) — the point where the digestive system's food tube meets the stomach.
The development of “mini eyes” by researchers at the UCL Great Ormond Street Institute of Child Health (UCL GOS ICH) has made it possible to study and comprehend the onset of blindness in the rare genetic disease known as Usher syndrome more.