Organoids are three-dimensional cell cultures from embryonic stem cells or induced pluripotent stem cells that model important features of whole organs.
Researchers at ETH Zurich have created a technique that enables them to genetically alter every animal cell in a unique way.
Researchers in the Cho Lab at Seoul National University’s College of Veterinary Medicine, are using the VACUSAFE safe aspiration system and VACUSIP portable aspiration system from INTEGRA Biosciences to help them culture organoids from cancer-stricken domesticated dogs as part of a comparative medicine research initiative.
Investigators are learning more about how schizophrenia develops by investigating the most powerful known genetic risk factor.
Organoids have now been created from stem cells to secrete the proteins that form dental enamel, the substance that protects teeth from damage and decay.
Researchers have developed a synthetic extracellular matrix (ECM) that can facilitate the development of a miniature endometrium in a dish for at least two weeks.
Oxidative stress, caused by an imbalance of free radicals and antioxidants, regularly reduces the yield of pharmaceuticals and therapeutics produced via bioprocessing by about 10-15%. Now, Xheme, Inc.'s Xheme Multifunctional Additive (XMA), a programmable non-toxic nanoporous microparticle, has demonstrated the ability to significantly reduce or eliminate the damage of oxidative stress in bioprocessing conditions.
According to a recent Northwestern Medicine study published in Nature Communications, aerobic glycolysis, the process by which cells convert glucose into lactate, is essential for eye development in mammals.
Researchers at University of Michigan developed a method to produce artificially grown miniature brains -; called human brain organoids -; free of animal cells that could greatly improve the way neurodegenerative conditions are studied and, eventually, treated.
Variations in gene activity based on where a cell is in a tumor have been discovered by researchers with the help of 3-D models of ovarian cancer tumors.
Pregnancy last around nine months in humans, only 20 days in mice, and up to 17 months in rhinoceroses. Even though many mammalian species go through the same phases of embryo development, the rate of development varies greatly between animals.
Lung mesenchymal cells, which are crucial components of the lung’s distinctive structure, also play a significant role in disease and injury recovery, but research into their biology and how they start disorders like pulmonary fibrosis is limited.
Scientists from the NIHR Great Ormond Street Hospital Biomedical Research Centre (a collaboration between GOSH and UCL), London, and University of Padova, Italy, have shown for the first time how 3D printing can be achieved inside 'mini-organs' growing in hydrogels -- controlling their shape, activity, and even forcing tissue to grow into 'molds.'
Human pluripotent stem cells were effectively transformed into purified pituitary cells, which aggregated into hormone-secreting organoids.
Each gene in the human DNA has a start and an endpoint. It is critical to correctly define the gene's extremities to make functional proteins. Much study has been conducted to identify what determines when, where, and at which place on the DNA a gene “starts.”
Genomic studies of cancer patients have revealed thousands of mutations linked to tumor development.
Researchers created organoids from cancer cells to reduce the need for trial and error in identifying effective cancer treatments in one of many cancer studies scheduled for presentation this week at Digestive Disease Week (DDW) 2023.
Scientists of the Princess Máxima Center for pediatric oncology and Hubrecht Institute in the Netherlands have revealed new scientific insights into the features of fibrolamellar carcinoma (FLC), a rare type of childhood liver cancer
Developing and testing new treatments or vaccines for humans almost always requires animal trials, but these experiments can sometimes take years to complete and can raise ethical concerns about the animals' treatment.
A new chip that holds different cell types in tiny, interconnected chambers could allow scientists to better understand the physiological and disease interactions between organs.
A team led by Masaya Hagiwara of RIKEN national science institute in Japan has developed an ingenious device, using layers of hydrogels in a cube-like structure, that allows researchers to construct complex 3D organoids without using elaborate techniques.