Organoids are three-dimensional cell cultures from embryonic stem cells or induced pluripotent stem cells that model important features of whole organs.
A research team has created brain tissue organoids in a tiny 3D-printed system that helps them observe as they grow and develop.
Human cells typically transcribe half of their roughly 20,000 genes into RNA molecules at any given time. Just like with proteins, the function of those RNA species not only relies on their abundance but also their precise localization within the 3D space of each cell.
Hormones produced by the thyroid gland are essential regulators of organ function. The absence of these hormones either through thyroid dysfunction due to, for example, irradiation, thyroid cancer or autoimmune disease or thyroidectomy leads to symptoms like fatigue, feeling cold, constipation, and weight gain.
Imagine if surgeons could transplant healthy neurons into patients living with neurodegenerative diseases or brain and spinal cord injuries.
Tissue stem cells can self-renew and differentiate, supplying cells necessary for tissues at various developmental stages.
A new study of autism risk genes by UC San Francisco and UC Berkeley scientists implicates disruption in prenatal neurogenesis - a process in which specialized "progenitor" cells give rise to new brain cells - in the development of autism spectrum disorders (ASDs).
A City of Hope-led research team found that the same gene that increases the risk for Alzheimer's disease, ApoE4, can increase the susceptibility to and severity of COVID-19.
Scientists from the Lerner Research Institute at Cleveland Clinic have designed an innovative, patient-derived model of ulcerative colitis that will help scale up studies into new therapies for chronic inflammatory bowel disease.
Organoids are tissues that look like organs and are extracted from stem cells cultured in laboratories. They are usually known as miniature organs.
News-Medical talks to Dr. Mo Ebrahimkhani about his research using genetic engineering together with a machine-learning algorithm to mature a lab-grown 'designer liver organoid'.
A breakthrough in microscopy and endoscopy will soon revolutionize the study of the cellular origin of diseases, advancing the field of precision medicine.
Finding just the right model to study human development--from the early embryonic stage onward--has been a challenge for scientists over the last decade.
Using sophisticated 3D genomic mapping and integrating with public data resulting from genome-wide association studies (GWAS), researchers at Children's Hospital of Philadelphia (CHOP) have found significant genetic correlations between inflammatory bowel disease (IBD) and stress and depression.
A team of Duke University researchers has developed a lab-grown living lung model that mimics the tiny air sacs of the lungs where coronavirus infection and serious lung damage take place. This advance has enabled them to watch the battle between the SARS-CoV-2 coronavirus and lung cells at the finest molecular scale.
'Mini-lungs' grown from tissue donated to Cambridge hospitals has provided a team of scientists from South Korea and the UK with important insights into how COVID-19 damages the lungs.
For a tiny embryo to develop into an adult organism, its cells must develop in precise patterns and interact with their neighbors in carefully orchestrated ways.
Organoids are stem cell-based tissue surrogates that can mimic the structure and function of organs, and they have become a key component of numerous types of medical research in recent years.
Scientists from King's College London have discovered an unexpected tissue reparative role for a rare immune cell type in the gut that could tip toward fibrosis or cancer if dysregulated.
Researchers who were exploring ways to establish the feasibility of batches of small liver organoids have now identified a new testing approach.
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