Organoids News and Research

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Organoids are three-dimensional cell cultures from embryonic stem cells or induced pluripotent stem cells that model important features of whole organs.

Study Sheds Light on Human Neocortex Evolution

Neurobiologists are certain that the neocortex is the defining factor that distinguishes humans.

28 Mar 2024

Constructing a Structured Illumination Microscopy Add-On

EPFL scientists have recently released a comprehensive manual detailing the construction of an add-on that can transform a regular optical microscope into a cutting-edge tool capable of generating high-resolution, three-dimensional images of cells, organoids, and embryos.

5 Mar 2024

Researchers Identify Proteins to Reprogram Fibroblasts into Limb Progenitor Cells

In a collaborative study, researchers from Kyushu University and Harvard Medical School have identified proteins that can turn or "reprogram" fibroblasts -; the most commonly found cells in skin and connective tissue -; into cells with similar properties to limb progenitor cells.

5 Mar 2024

Astrocyte-Rich Brain Organoid Model Unveils Insights into Neuroinflammation

The brain is typically depicted as a complex web of neurons sending and receiving messages. But neurons only make up half of the human brain.

1 Mar 2024

SOX17 Gene Identified as Critical for Immune Evasion in Early-Stage Colon Cancer

One of the immune system's primary roles is to detect and kill cells that have acquired cancerous mutations.

29 Feb 2024

New "Tissue-in-a-CUBE" Offers Alternative to Animal Testing in Drug Development

A research team at the RIKEN Center for Biosystems Dynamics Research (BDR) in Japan has succeeded in establishing a model of the blood-brain barrier using modularized tissue derived from human cells.

29 Feb 2024

Integrating Environmental Factors in Genetic Research: A New Perspective

It has long been known that there is a complex interplay between genetic factors and environmental influences in shaping behavior.

28 Feb 2024

Scientists Develop First Full Model of Early Human Central Nervous System with Stem Cells

The first stem cell culture method that produces a full model of the early stages of the human central nervous system has been developed by a team of engineers and biologists at the University of Michigan, the Weizmann Institute of Science, and the University of Pennsylvania.

27 Feb 2024

Stem Cell-Derived Brain Organoids on Ax-3 Mission Seek to Improve Modeling for Neurodegenerative Diseases

More than 5 million people worldwide are living with neurodegenerative disorders like Parkinson’s disease and primary progressive multiple sclerosis (PPMS).

19 Jan 2024

‘Mini-Placentas’ Help Scientists Study the Causes of Pre-eclampsia and Pregnancy Disorders

Scientists have grown ‘mini-placentas’ in the lab and used them to see how the placenta develops and interacts with the inner lining of the womb – findings that could help scientists better understand and, in future, potentially treat pre-eclampsia.

17 Jan 2024

Human Conjunctiva Model Developed For First Time

The Hubrecht Institute's Organoid group created the first organoid model of the human conjunctiva. The function of these organoids is mimicked by the human conjunctiva, a tissue involved in the formation of tears.

12 Jan 2024

Scientists Develop Tiny Human Cerebellums to Decipher Disease and Design Therapies

In a first for USC Stem Cell scientists, the laboratory of Giorgia Quadrato, an assistant professor of stem cell biology and regenerative medicine, has pioneered a novel human brain organoid model that generates all the major cell types of the cerebellum, a hindbrain region predominantly made up of two cell types necessary for movement, cognition, and emotion: granule cells and Purkinje neurons.

5 Jan 2024