Osteoporosis is a progressive metabolic bone disease that causes a decrease in bone density and gives rise to weak, fragile bones that are prone to fracture. Most commonly, these fractures occur in the spine, wrist and hips when a person falls or bumps into something. If such an event triggers a visit to the doctor, a test of the bone mineral density called a DEXA scan may be performed and reveal osteoporosis.
The term osteoporosis refers to the porous (spongy) state of bone that eventually manifests as the bone’s ability to replenish itself declines over time. When individuals reach the age of around 40, the rate of bone breakdown starts to exceed the rate at which it is replaced, creating increasingly larger holes in the bone that make it less dense and more prone to fracture.
Some of the risk factors for osteoporosis such as gender, age and family history for the condition cannot be changed. However, factors such as diet and activity level can be improved to increase bone strength and individuals are advised to exercise regularly, eat a diet rich in vitamin D and calcium, and quit any smoking or drinking habits.
Osteoporosis is currently thought to be affecting more than 200 million people worldwide but is most common among older, post-menopausal women who have reduced levels of estrogen, an important contributor to bone health.
New research has discovered a cell type that governs the way bones form and maintain themselves, opening up a potential target for future therapies for bone disorders like osteoporosis.
Researchers at Kumamoto University, Japan generated mice lacking the estrogen receptor beta (ERβ) gene, both fiber-specific and muscle stem cell-specific, which resulted in abnormalities in the growth and regeneration of skeletal muscle in female mice.
Findings from a new study among mice show a diet high in dried plum (prunes) completely prevents bone loss associated with spinal cord injury (SCI), while also restoring some of the bone lost following SCI.
Dr. O'Keefe speaks to AZoLifeSciences about his latest research that investigated how the pesco-mediterranean diet may lower the risk for heart disease.
According to results from a study, middle-aged mice had a better “old age” when the naturally-occurring metabolite, called AKG, was added to their food.
Oxytocin, produced by the hypothalamus and sometimes known as the "love hormone" for its involvement in pair bonding and orgasm, can be a strong ally in the control and prevention of osteoporosis, according to a study by scientists at São Paulo State University in Brazil.
An international team of scientists has developed a novel genetic measure that could dramatically improve how doctors assess the risk of sustaining a fracture due to osteoporosis or fragility.
Cambridge scientists have developed a new way to fortify shellfish to tackle human nutrient deficiencies which cause severe health problems across the world. The team is now working with major seafood manufacturers to further test their microencapsulation technology, or "Vitamin Bullets".
Osteoclasts are bone-dissolving cells that are extracted from a type of immune cell referred to as macrophages which are required for the maintenance of bones.