The pancreas is a gland organ in the digestive and endocrine system of vertebrates. It is both an endocrine gland producing several important hormones, including insulin, glucagon, and somatostatin, as well as an exocrine gland, secreting pancreatic juice containing digestive enzymes that pass to the small intestine. These enzymes help in the further breakdown of the carbohydrates, protein, and fat in the chyme.
Studies on cellular dynamics are vital to interpret the development of cells and the progression of various diseases.
Scientists at UCL have discovered new biomarkers, which may identify those people with Type 1 diabetes who would benefit from the immunotherapy drug Abatacept, a finding which could eventually help thousands manage the disease more effectively.
Cancer diagnosis requires a lengthy process of multiple analyses of tissue biopsies, impeding the quick and early detection of cancers.
Yale pharmacology professor Barbara Ehrlich and her team have uncovered a mechanism driving a rare, lethal disease called Wolfram Syndrome and also a potential treatment.
Type 1 diabetes mellitus and type 2 diabetes mellitus (T2DM) are the two main types of diabetes, while T2DM accounts for 90%-95% of those with diabetes.
A compound commonly found in pickled capers has been shown to activate proteins required for normal human brain and heart activity, and may even lead to future therapies for the treatment of epilepsy and abnormal heart rhythms.
Natural killer cells, a type of immune cell, are known to limit metastasis by inducing the death of cancer cells. But metastases still form in patients, so there must be ways for cancer cells to escape.
Researchers from CSHL have discovered that the growth of pancreatic cancer cells can be stopped by disrupting the way cholesterol is stored by the cells.
Scientists from the Diabetes Research Institute at the University of Miami Miller School of Medicine have developed a method allowing for the long-term culture of "pancreatic slices" to study the regeneration of the human pancreas in real time.
AZoLifeSciences speaks to Professor David J. Rawlings from the Seattle children's hospital about recent developments in engineered T cells for type 1 diabetes.
According to a study, the 3D structure of the human genome is fundamental to provide a quick and strong inflammatory response.
Scientists have developed a technique to assess the impact of particular drugs in pancreatic tissues by using an advanced single-cell RNA sequencing approach.
The loss of insulin-secreting beta cells leads to type 1 diabetes. Islet cell transplantation has the potential to cure diabetes, but donors are rare.
Chronic pancreatitis, or persistent inflammation of the pancreas, is a known risk factor that leads to the development of pancreatic cancer, which is the third-deadliest cancer in the United States.
At St. Jude Children’s Research Hospital, researchers have generated a database that detects gene-regulatory mechanisms in immune cells that promote Type 1 diabetes.
Transplanted islet cells that release insulin during very low blood sugar levels offer a potential way for treating diabetes.
Researchers have discovered that pancreatic cells, producing lipids, can create their own autoimmune ending. This article looks at how this is possible.