The pancreas is a gland organ in the digestive and endocrine system of vertebrates. It is both an endocrine gland producing several important hormones, including insulin, glucagon, and somatostatin, as well as an exocrine gland, secreting pancreatic juice containing digestive enzymes that pass to the small intestine. These enzymes help in the further breakdown of the carbohydrates, protein, and fat in the chyme.
At the Shanghai Institute of Nutrition and Health (SINH) of the Chinese Academy of Sciences (CAS), a research group headed by Professor Zhen Shao and the collaborators plotted a high-resolution roadmap for the process of pancreatic β cell regeneration by in vivo transdifferentiation from adult acinar cells with the help of a single-cell RNA sequencing (scRNA-seq) technology.
A gene expression signature that has the potential to forecast the advance of type 1 diabetes has been determined by scientists from Turku Bioscience Centre and InFLAMES Flagship at the University of Turku in Finland.
To many people, the sugars we eat may seem like a luxury that can do more harm than good. But now, researchers from Japan have discovered that in insects, dietary sugars play a key role in reproduction.
Discussions of cancer often stress the genetic mutations that drive disease by altering the normal function of cellular proteins.
Researchers at the Department of Biology, University of Copenhagen, have now contributed to solving this problem for a specific gene called GCK. The study has just been published in Genome Biology.
Even as pancreatic cancer treatments advance, only around 9% of patients live beyond five years. Scientists have failed to identify genetic distinctions that explain why some patients live for a long time and others do not, so they have moved their emphasis to the gut microbiome.
Therapeutics that use mRNA-;like some of the COVID-19 vaccines-;have enormous potential for the prevention and treatment of many diseases.
A team of scientists from the Van Andel Institute and the Max Planck Institute for Immunobiology and Epigenetics uncovered two unique subtypes of insulin-producing beta cells, or ß cells, each having important traits that could potentially be used to better understand and treat Type 1 and Type 2 diabetes.
Up-and-coming local biotech startup BetaLife Pte Ltd ("BetaLife") is collaborating with the Agency for Science, Technology and Research (A*STAR) to accelerate the development of next generation cell-based therapy for diabetes.
More than 37 million Americans have diabetes, and approximately 90-95% have Type 2 diabetes.
Multiple types of beta cells produce insulin in the pancreas, helping to balance blood sugar levels. Losing a particularly productive type of beta cell may contribute to the development of diabetes, according to a new study by Weill Cornell Medicine investigators.
An artificial pancreas originally developed at the University of Virginia Center for Diabetes Technology improves blood sugar control in children ages 2 to 6 with type 1 diabetes, according to a new study.
Consuming a diet rich in vitamin A or its analogs may help prevent children and young adults with acute lymphoblastic leukemia (ALL) reduce their risk of developing painful pancreas inflammation during chemotherapy treatment.
Published in JAMA, a University of Minnesota led study shows that verapamil, a drug commonly used to treat high blood pressure and heart conditions, can have a beneficial effect on the pancreas in children with newly-diagnosed type 1 diabetes (T1D).
Takeaki Ozawa and his team from the University of Tokyo reveal the metabolic reactions upon activating an enzyme called Akt2.
A new review was published in Genes & Cancer on February 1, 2023, entitled, "CEACAMS 1, 5, and 6 in disease and cancer: interactions with pathogens."
When cells copy DNA to produce RNA transcripts, they include only some chunks of genetic material known as exons and throw out the rest.
Although it has long been believed that microRNA (miRNA) molecules in pancreatic islets play significant roles in Type 2 diabetes, no specific miRNAs have been definitively linked to the disease in humans.
A massive clinical study on an approved psoriasis drug is now underway. The drug will be tested on people who have just been diagnosed with type 1 diabetes. The drug, according to the theory, could preserve the patient’s remaining insulin production.
Insulin injections to treat Type 1 diabetes could become a thing of the past, but finding the cure faces many challenges.