Polymerase News and Research

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Identifying How a Particular Riboswitch Regulates its Synthesis

Researchers across the world are in search of ways to combat bacteria that could evade the present arsenal of antibiotics. This is done as a measure to avoid a global health crisis.

2 Jun 2023

Deep-Sequencing Identifies Over 10,000 Unique Genes in Cotton

TEs (transposable elements), particularly LTRs, are recognized to play a crucial role in defining basic genome organization and affecting functional gene expression. Insertion of TE or LTR fragments may also result in the formation of new transcription start sites (TSSs) in the host genome.

25 May 2023

Study Provides a New Picture of How Bacterial Cells Repair Faulty DNA

A new study adds to an emerging, radically new picture of how bacterial cells continually repair faulty sections of their DNA.

17 May 2023

A Rapid Method for the Quantitative Detection of miRNA

Researchers investigating the growth of a roundworm discovered a tiny RNA molecule that controlled the expression of specific genes in the early 1990s. This resulted in the discovery of microRNAs (miRNAs), which are now known to exist in all forms of life. These molecules, it turns out, play vital functions in a variety of biological processes.

26 Apr 2023

First Steps Driving Antibiotic Resistance Discovered

Antibiotic resistance is a global health threat. In 2019 alone, an estimated 1.3 million deaths were attributed to antibiotic resistant bacterial infections worldwide.

3 Apr 2023

Cancer cells use new DNA repair mechanism to recover from next-generation cancer radiation therapy

A team of scientists led by Dr. Kei-ichi TAKATA from the Center for Genomic Integrity within the Institute for Basic Science (IBS), has discovered a new type of DNA repair mechanism that cancer cells use to recover from next-generation cancer radiation therapy.

20 Mar 2023

Highly sensitive bioluminescent platform for nucleic acid detection

Despite significant advances, numerous highly sensitive viral disease diagnostic tests even now require complex techniques to prepare a sample or decipher a result, making them inconvenient for point-of-care settings or areas with limited resources.

17 Mar 2023

Using data from Sanger sequencing to quantify of genetic variants in bacterial cultures

Genetic variations, such as mutations, recombinations, or transpositions occur naturally in cultured microorganisms and are often considered nonneutral mutations.

7 Mar 2023

Effective and faster methodology detects RNA viruses based on the triplex-forming probe technology

Experts from the University of Barcelona, the Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), the Institute of Microelectronics of Barcelona (IMB-CNM-CSIC) and the Aragon Nanoscience and Materials Institute of Aragon (INMA) -;a joint institute of the CSIC and the University of Zaragoza-; have developed a new method to detect RNA viruses based on the triplex-forming probe technology.

28 Feb 2023

AutoPLP helps detect mutating pathogenic variants quickly and accurately

As we now know from our experience with the COVID-19 pandemic, the microbes responsible for some infections can rapidly mutate into variants that evade detection and treatment.

16 Feb 2023

Semi-quantitative system employs eDNA to detect endangered species

Alteration in river systems, overfishing, and the introduction of new, invasive species can all lead to a significant decrease in the number of native fish found in aquatic ecosystems.

8 Feb 2023

“Reference Epigenome” and regulatory mechanisms in wheat embryogenesis

One of the most basic and amazing processes that occur in both plants and animals is embryogenesis. It is incredible that, within a matter of weeks after fertilization, a single mother egg cell can transform into a living thing with a complex body structure.

6 Feb 2023

New scalable approach for the diagnosis of multiple respiratory viruses

Cambridge scientists have created a novel test that “fishes” for many respiratory viruses at once using single strands of DNA as “bait” and provides extremely accurate results in under an hour.

18 Jan 2023

Electrochemical biosensor for detecting antibodies

Although it frequently necessitates a challenging laboratory procedure, the quantitative detection of specific antibodies in complex samples like blood can provide information on a variety of diseases.

18 Jan 2023

Revealing the unappreciated role of POLQ in responding to DNA replication stress

Researchers at the Francis Crick Institute, in partnership with Artios, have discovered how an enzyme involved in DNA repair (POLQ) becomes critical to the survival of some tumors when the cancer cells lose the ability to employ a more frequent way of DNA repair.

1 Dec 2022

Revealing the functional significance of DDX41 in great detail

The DDX41 gene encodes the nuclear enzyme DEAD-box-type RNA helicase. Hematopoietic malignancies are caused by DDX41 mutations. However, the mechanism behind the development of this malignancy remains unknown.

21 Nov 2022

Providing structural understanding of the influenza virus

The structure of the influenza replication machinery and how it interacts with cellular proteins have been solved by a team of Oxford University scientists using a variety of techniques at Diamond Light Source.

8 Nov 2022

A strong enzyme that functions similar to a Swiss army knife

Blue-green algae, also known as cyanobacteria, have a superpower that likely contributes to their extreme success as waterway invaders. They have a remarkable capacity to store nitrogen and energy in their cells for use when necessary.

3 Oct 2022

Study highlights the history of ancient DNA technology development

Ancient DNA (aDNA) technology has been used for the past ten years by researchers working under the direction of FU Qiaomei at the Institute of Vertebrate Paleontology and Paleoanthropology (IVPP) of the Chinese Academy of Sciences (CAS) to learn more about the history of ancient human populations, particularly those in East Asia.

26 Jul 2022

Researchers review the major milestones of ancient DNA techniques

Ancient DNA (aDNA) technology has been used for the past ten years by researchers working under the direction of Qiaomei Fu at the Institute of Vertebrate Paleontology and Paleoanthropology (IVPP) of the Chinese Academy of Sciences (CAS) to learn more about the past of ancient human populations, particularly those in East Asia.

25 Jul 2022