Programmed Cell Death News and Research

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New CRISPR RNA-guided Caspases could lead to promising antiviral and tissue engineering tools

New research from Cornell offers insights into a line of CRISPR systems, which could lead to promising antiviral and tissue engineering tools in animal and plants.

26 Aug 2022

Researchers determine a novel antiviral technique to combat bacteria

Bacteria use a wide range of defense strategies to combat viral infection, and some of these systems have resulted in game-changing technologies like CRISPR-based gene editing.

From Massachusetts Institute of Technology (MIT) 15 Aug 2022

Study provides guidelines on how to design safer CRISPR reagents

The 2020 Nobel Prize in Chemistry was awarded to Jennifer A. Doudna and Emmanuelle Charpentier for developing the widely utilized and incredibly precise genome editing method known as CRISPR/Cas9

11 Aug 2022

Scientists demonstrate a new function of an enzyme that connects to age-related diseases

Aging and age-related diseases present a complex challenge to biomedical researchers.

20 Jul 2022

Researchers discover a mechanism by which the protein DELE1 detects organelle stress

Researchers have long speculated an association between disorders in mitochondria, tiny organelles inside the cell, and the aging process and age-related illnesses.

11 Apr 2022

Study shows that mechanical stress help cancer cells metastasize

A recent study shows that compressing cancer cells through tight spaces makes them more violent and helps them avoid cell death.

9 Mar 2022

Microbes hindering cancer therapy seem to play a bigger role than helpful ones

Melanoma patients receiving therapy that helps their immune system kill cancer cells respond to treatment differently depending on the types of microbes in their gut, and new research suggests the microorganisms hindering therapy have more influence than the beneficial ones.

1 Mar 2022

Scientists elucidate mechanism that causes treatment resistance in aggressive pancreatic cancer

Drug resistance is a major obstacle in the treatment of cancers. In an aggressive type of pancreatic cancer, for instance, drug resistance is associated with the suppression of programmed cell death, which results in the uncontrolled growth of cancer cells.

25 Feb 2022

Study reveals how the body controls inflammation during removal of damaged cells

A research team from Cologne and Osnabrück has investigated in detail how messenger substances signal inflammation during the removal of damaged cells in the body.

7 Feb 2022

New finding could lead to the development of cell death regulators for cancer therapies

Scientists led by Professor Ana J. Garcia-Saez at the CECAD Cluster of Excellence for Aging Research at the University of Cologne have shown that apoptosis, the programmed cell death, involves a direct physical interplay between the two proteins BAX and DRP1.

17 Jan 2022

Simple, marine-dwelling creature shines light on cancer resistance

A simple, marine-dwelling creature known as Trichoplax adhaerens has some remarkable properties. The organism can tolerate unusually high doses of radiation that would kill most other forms of life. T. adhaerens has another intriguing characteristic: the ability to resist cancer.

24 Dec 2021

Study identifies novel function for existing protein

Researchers recently identified a new role of the protein tBID, which was to date linked to the regulatory role in cancer and cell death. But tBID also directly mediates apoptosis (controlled cell death).

23 Dec 2021

CRISPR introduces potentially dangerous changes in cells, reveals research

New research revealed that gene editing, particularly gene knockout, with CRISPR-Cas9 can support cells with mutated gene forms associated with cancer.

15 Nov 2021

Study identifies protein complex that confers neuroprotection against HSV-1 infection

Recent research by scientists from the University of Illinois demonstrates a process that halts the herpes simplex virus 1 from inducing severe brain damage and death.

15 Oct 2021

High levels of polyunsaturated fatty acids in liver cells linked to hepatitis C virus resistance

Hepatitis C virus thrives in humans for years, damaging the liver by causing chronic inflammation, eventually resulting in cirrhosis and liver cancer.

4 Oct 2021

Newly identified antibacterial mechanism could inspire novel strategies to combat bacterial pathogens

Similar to how a spider traps its prey, the cells of the human immune system cooperate to trap and “eat” bacteria.

14 Sep 2021

Study details the role of PANoptosome in activating innate immune response

Immunologists discovered how immune sensors in infected cells organize and initiate an immune response to infections with living bacteria and viruses.

3 Sep 2021

Study reveals the biology and treatment behind rare rheumatoid-like autoinflammatory condition

The absence of a protein that activates the body's antiviral defenses can cause a rare rheumatoid-like autoinflammatory condition that is treatable with an FDA-approved class of drugs known as TNF (tumor necrosis factor) inhibitors, a global research team led by Mount Sinai has found.

20 Aug 2021

High expression of cell death genes linked to increased risk of dying early from lung cancer

Patients with a high number of genes most associated with pathways that lead to cell death in lung cancer are at increased risk of dying early from their disease, researchers report.

6 Apr 2021

Gut microbiome alterations help melanoma patients to respond to immunotherapy

Statistical modeling developed by Oregon State University researchers has confirmed that changes to melanoma patients' gut microbiome led them to respond to a type of treatment capable of providing long-term benefit.

17 Feb 2021