RNA Interference News and Research

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Unraveling the Molecular Basis of SIDT1 and SIDT2 in C. elegans

New work thoroughly characterizes the structural features of human SIDT1 and SIDT2, revealing their existence as dimers in vitro and their tendency to form dimers or higher-order oligomers in their natural environment.

23 Nov 2023

Genes Responsible for Aging Identified in Nematodes

The USask research team uncovered a pair of genes involved in removing cells of toxins that build in the body and cause aging while working with small nematode worms called C. elegans. The researchers discovered that inactivating genes named CCF-1 and PAL-1 caused nematodes to die 50% faster than usual.

3 May 2023

Using a programmable control switch to deliver therapeutic RNA molecules to target cells

Using an RNA sensor, MIT engineers have designed a new way to trigger cells to turn on a synthetic gene.

17 Mar 2023

A reliable way to downregulate gene translation in plants

By carefully constructing upstream open reading frames (uORFs), Caixia Gao’s team at the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences (CAS) has created a new technique for downregulating gene translation to a predictable and desirable level in plants.

10 Mar 2023

Study reveals how RNAi workhorse protein optimizes to keep protein synthesis on track

Proteins are made in cells in the same way as they are made in factories. However, making too much at the wrong moment may lead to illnesses like cancer, so they use RNA interference (RNAi) to regulate production.

1 Jun 2022

Researchers use specific enzymes to tear down viral RNA

The genetic information of SARS-CoV-2 has been successfully destroyed by a research team led by the Technical University of Munich.

4 Mar 2022

Research focuses on how short-term genetic memories can be inherited across generations

A gene-silencing tool could enable new opportunities for advancing basic biomedical research and drug development.

4 Feb 2022

Study unravels factors involved in risiRNA generation

A team of scientists disclosed the nucleolar RNA interference based on Caenorhabditis elegans (C. elegans) as a model organism.

1 Oct 2021

Mapping the genome of Eurasian spruce bark beetle reveals new insights

Researchers have successfully mapped the entire genome of the Eurasian spruce bark beetle. The breakthrough paves the way for new research into bark beetles and better prospects for effective pest control of a species that can destroy more than 100 million cubic meters of spruce forest during a single year in Europe and Asia.

30 Sep 2021

Researchers discover the role of a retrotransposon in horizontal memory transfer in roundworms

When an organism encounters a threat in its environment, it is to the species' advantage to warn others of the peril.

6 Sep 2021

Newly identified protein regulates the flow of materials in the Drosophila ovary

According to a research work performed by Northwestern Medicine and published in the Current Biology journal, a protein helps guide the flow of materials in the ovary of Drosophila fruit flies during the formation of egg cells.

17 Jun 2021

Genetic and molecular mechanisms make chemotherapy drug work for some cancer patients

The chemotherapy drug decitabine is commonly used to treat patients with blood cancers, but its response rate is somewhat low. Researchers have now identified why this is the case, opening the door to more personalized cancer therapies for those with these types of cancers, and perhaps further afield.

25 May 2021

Study could help develop peptide siRNA carrier for human oral cancer

MUSC Hollings Cancer Center researchers are exploring the use of peptide carriers for the delivery of small RNA drugs as a novel treatment for cancer. The team's recent work, published online March 19 in the Molecular Therapy - Nucleic Acids journal, lays the foundation for developing a clinically relevant peptide carrier RNAi-based drug treatment strategy for human oral cancer.

25 May 2021

Successful class of therapeutics attack and shut down unique and harmful genes

A potential class of therapeutics that uses synthetic nucleic acids to attack and shut down harmful genes while preventing viral spread is gathering momentum.

18 May 2021

Toxin in potatoes is a divergent of bitter-tasting compound in tomatoes

A multi-institutional collaboration has revealed that α-solanine, a toxic compound found in potato plants, is a divergent of the bitter-tasting α-tomatine, which is found in tomato plants.

26 Mar 2021

Absence of TRIM37 protein boosts genetic instability in patients with Mulibrey syndrome

Researchers from the Andalusian Centre for Molecular Biology and Regenerative Medicine (CABIMER), in collaboration with the Swiss Institute for Experimental Cancer Research (ISREC) have studied the mechanisms behind the higher tendency of people with Mulibrey syndrome to develop tumors.

1 Mar 2021

Study elucidates genes responsible for Glioblastoma invasiveness

One of the hallmarks of Glioblastoma (GBM), the most aggressive type of brain cancer, is its high invasive capacity, which leads to its expansion into the normal brain tissue.

14 Dec 2020

Researchers identify new potential therapeutic targets for SARS-CoV-2 infection

To identify new potential therapeutic targets for SARS-CoV-2, a team of scientists at the New York Genome Center, New York University, and the Icahn School of Medicine at Mount Sinai, performed a genome-scale, loss-of-function CRISPR screen to systematically knockout all genes in the human genome.

27 Oct 2020

Researchers develop a new method for siRNA stabilization

In the gene controlling mechanism, known as RNA interference, the expression of particular genes is downregulated by siRNAs or endogenic microRNAs.

19 Oct 2020

Using CRISPR/Cas9 technology in trees for a bio-based economy

Researchers led by prof. Wout Boerjan (VIB-UGent Center for Plant Systems Biology) have discovered a way to stably finetune the amount of lignin in poplar by applying CRISPR/Cas9 technology.

7 Oct 2020