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Researchers suggest new strategies for finding drugs that neutralize key enzymes

Scientists from the UK's University of Bath explore racemases - an important type of enzyme that is linked to certain cancers and other life-threatening diseases while also being critical to cell function - in a paper published in the prestigious journal Chemical Society Reviews. The scientists also propose new strategies for finding drugs that neutralize these enzymes.

From University of Bath 26 May 2021

Latest articles provide novel insights into the mechanisms driving pridopidine neuroprotective effects

Prilenia Therapeutics B.V., a clinical stage biotech company focused on developing novel treatments for neurodegenerative and neurodevelopmental disorders, today announces the publication of three peer-reviewed journal articles, highlighting key aspects of the mechanism of action of its lead asset, pridopidine, and the importance of S1R activation as a mechanism to attenuate biological features of neurodegenerative diseases.

25 May 2021

Study could help develop peptide siRNA carrier for human oral cancer

MUSC Hollings Cancer Center researchers are exploring the use of peptide carriers for the delivery of small RNA drugs as a novel treatment for cancer. The team's recent work, published online March 19 in the Molecular Therapy - Nucleic Acids journal, lays the foundation for developing a clinically relevant peptide carrier RNAi-based drug treatment strategy for human oral cancer.

25 May 2021

“Paralyzed” immune cells can be reactivated by drugs in IDH-mutant gliomas

Brain tumor cells with a certain common mutation reprogram invading immune cells. This leads to the paralysis of the body's immune defense against the tumor in the brain. Researchers from Heidelberg, Mannheim, and Freiburg discovered this mechanism and at the same time identified a way of reactivating the paralyzed immune system to fight the tumor.

25 May 2021

New method helps tests large groups for SARS-CoV-2 infection

Researchers at the Vienna BioCenter designed a testing protocol for SARS-CoV-2 that can process tens of thousands of samples in less than 48 hours. The method, called SARSeq, is published in the journal Nature Communications and could be adapted to many more pathogens.

25 May 2021

Study establishes link between heat stress and crop yield

Scientists report that it is possible to detect and predict heat damage in crops by measuring the fluorescent light signature of plant leaves experiencing heat stress.

25 May 2021

Telomere length decreases most rapidly from birth to age 3, shows study

Telomeres are protective caps on DNA that shorten as we grow older. Now, one of the first studies to examine telomere length (TL) in childhood finds that the initial setting of TL during prenatal development and in the first years of life may determine one's TL throughout childhood and potentially even into adulthood or older age.

25 May 2021

Plant-based technology reveals key process in virus infection cycle in dynamic detail

A critical process in the infection cycle of viruses has been revealed for the first time in dynamic detail using pioneering plant-based technology.

25 May 2021

Environmental DNA helps track down species on the move

Many individuals would like to prevent sloughed-off skin and bodily fluids. However, for marine biologists like Cheryl Lewis Ames, Associate Professor of Applied Marine Biology in the Graduate School of Agricultural Science at Tohoku University (Japan), such life remnants have become a magical guide to detecting the unseen.

24 May 2021

Gene expression signatures underlying microglia linked with amyloid plaque phagocytosis

Alzheimer’s disease is the most prevalent form of dementia distinguished by the accumulation of amyloid plaques in the brain.

24 May 2021

New genetic pathway plays a critical role in the ripening of tomatoes

An international research team has found that a genetic pathway known as CHLORAD, also plays a critical role in the ripening of tomatoes.

24 May 2021

Lithium concentration in the brains of depressed people varies from healthy people

Depressive diseases are among the most common illnesses in the world.

24 May 2021

Climate change could make railway infrastructure vulnerable to greater damages

Just half a degree Celsius less warming would save economic losses of Chinese railway infrastructure by approximately $0.63 billion per year, according to a new paper published by a collaborative research team based in Beijing Normal University and the Institute of Atmospheric Physics, Chinese Academy of Sciences, China.

24 May 2021

Researchers discover dramatic changes in the chemistry and composition of Sargassum

For centuries, pelagic Sargassum, floating brown seaweed, have grown in low nutrient waters of the North Atlantic Ocean, supported by natural nutrient sources like excretions from fishes and invertebrates, upwelling and nitrogen fixation.

24 May 2021

Convergence science are needed to prevent plant disease outbreaks

Plant diseases don't stop at national borders and miles of oceans don't prevent their spread, either. That's why plant disease surveillance, improved detection systems, and global predictive disease modeling are necessary to mitigate future disease outbreaks and protect the global food supply, according to a team of researchers in a new commentary published in Proceedings of the National Academy of Sciences.

24 May 2021

Study reveals urine protein biomarkers of bladder cancer

Oncotarget published "Urine protein biomarkers of bladder cancer arising from 16-plex antibody-based screens" which reported that the current study examines urine samples from 66 subjects, comprising of 31 Urology clinic controls and 35 bladder cancer patients, using a Luminex based screening platform.

24 May 2021

Studies highlight different aspects of link between obesity and cancer

Multi-factorial metabolic and inflammatory abnormalities in obesity, independently or in combination, seems to be the critical biological link of obesity, cancer and racial/gender health disparities. However, the specific cross-talk between these factors remain elusive.

24 May 2021

Exposure to chemicals in plastic during the fetal stage is linked with a lower IQ

Bisphenol F chemical (found in plastics) may cause changes in a gene that is crucial for neurological development. Researchers from the Swedish universities of Uppsala and Karlstad made this discovery.

21 May 2021

Human self-organizing cardiac organoids mimic the architecture of a heart chamber

Self-organizing heart organoids created at the Austrian Academy of Sciences’ Institute of Molecular Biotechnology (IMBA) are also efficient injury and in vitro congenital disease models. These “cardioids” have the potential to transform studies into cardiovascular diseases and heart malformations.

21 May 2021

Three-dimensional organization of genome is extremely dynamic during gamete formation

Inside the nuclei of cells, the genome is tightly organized (packaged). This three-dimensional (3D) genome organization is basic because it controls gene expression.

21 May 2021

Research News and Research

Researchers suggest new strategies for finding drugs that neutralize key enzymes

Latest articles provide novel insights into the mechanisms driving pridopidine neuroprotective effects

Study could help develop peptide siRNA carrier for human oral cancer

“Paralyzed” immune cells can be reactivated by drugs in IDH-mutant gliomas

New method helps tests large groups for SARS-CoV-2 infection

Study establishes link between heat stress and crop yield

Telomere length decreases most rapidly from birth to age 3, shows study

Plant-based technology reveals key process in virus infection cycle in dynamic detail

Environmental DNA helps track down species on the move

Gene expression signatures underlying microglia linked with amyloid plaque phagocytosis

New genetic pathway plays a critical role in the ripening of tomatoes

Lithium concentration in the brains of depressed people varies from healthy people

Climate change could make railway infrastructure vulnerable to greater damages

Researchers discover dramatic changes in the chemistry and composition of Sargassum

Convergence science are needed to prevent plant disease outbreaks

Study reveals urine protein biomarkers of bladder cancer

Studies highlight different aspects of link between obesity and cancer

Exposure to chemicals in plastic during the fetal stage is linked with a lower IQ

Human self-organizing cardiac organoids mimic the architecture of a heart chamber

Three-dimensional organization of genome is extremely dynamic during gamete formation

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