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New 3D organoid model reveals a possible biological target for treating GEJ cancers

Researchers at Johns Hopkins Medicine say they have created a laboratory-grown three-dimensional "organoid" model that is derived from human tissue and designed to advance understanding about how early stages of cancer develop at the gastroesophageal junction (GEJ) — the point where the digestive system's food tube meets the stomach.

2 Dec 2022

High-dose green tea extract may create liver damage in people with certain genetic variations

Long-term use of high-dose green tea extract may provide some protection against cancer, cardiovascular disease, obesity and type 2 diabetes, but it also may create liver damage in a small minority of the population.

2 Dec 2022

Investigating new ways to grow food in space

Growing food in space is fraught with daunting challenges, including extreme environmental stressors like radiation and microgravity.

2 Dec 2022

The analysis of pesticide residues in cannabis and hemp products

In this interview, Avinash Dalmia, the Senior Principal Application Scientist at PerkinElmer, talks to AZoLifeSciences about the analysis of 102 pesticides and 5 mycotoxin residues in hemp regulated by colorado state.

From PerkinElmer Cannabis & Hemp Testing Solutions 2 Dec 2022

Preventing protein-protein interactions with a new tool

Proteins constantly interact with one another inside cells to perform various tasks. Blocking the binding of two or more proteins appears as a potential treatment for some diseases where these functions are altered.

1 Dec 2022

Specific genetic variant resulting in the early onset of epilepsy identified

Children’s Hospital of Philadelphia (CHOP) researchers have identified a particular genetic variant in SCN1A, the most common genetic epilepsy, that contributes to an earlier start of epilepsy with clinical features different from other epilepsies.

1 Dec 2022

Revealing the unappreciated role of POLQ in responding to DNA replication stress

Researchers at the Francis Crick Institute, in partnership with Artios, have discovered how an enzyme involved in DNA repair (POLQ) becomes critical to the survival of some tumors when the cancer cells lose the ability to employ a more frequent way of DNA repair.

1 Dec 2022

Research could advance our understanding of evolution and the origins of cell motility

The origin of all biological movements, including walking, swimming, or flying, can be traced back to cellular movements; however, little is known about how cell motility arose in evolution.

1 Dec 2022

Three-year interval appropriate between screening for colorectal cancer

Three years after the first negative multi-target stool DNA test, according to a scientific investigation into the best time to screen for colorectal cancer using non-invasive methods for detecting the disease’s targets in the stool, there were no colorectal malignancies discovered.

1 Dec 2022

Nitrogen metabolism adaptations allowed marine cyanobacteria to survive in the ocean

The UCO publishes a review of the nitrogen metabolism adaptations that allowed the most abundant photosynthetic organism on Earth, marine cyanobacteria, to survive in environments very poor in nutrients.

30 Nov 2022

Bats use distinct laryngeal structures to generate echolocation and social calls

Bats use distinct structures in the larynx to produce high-frequency echolocation calls and lower-frequency social calls, according to a study by Coen Elemans at the University of Southern Denmark and colleagues, publishing November 29th in the open access journal PLOS Biology.

30 Nov 2022

Using nanotechnology and magnetic manipulations to bioengineer 3D neural networks

Neurons are the fundamental units of the brain and nervous system, the cells responsible for receiving sensory input from the external world, for sending motor commands to our muscles, and for transforming and relaying the electrical signals at every step in between.

30 Nov 2022

Acute infection disrupts the healthy balance between the good and bad gut microbes

Rutgers researchers examined the impact of COVID-19 on patients’ microbiomes, the group of microbes that live in and on the human body.

30 Nov 2022

Insight into the treatment for Crimean Congo Hemorrhagic Fever Virus

The Crimean Congo Hemorrhagic Fever Virus can be prevented by therapeutically relevant human monoclonal antibodies, according to research led by the University of California, Riverside.

30 Nov 2022

Revealing the mechanism that ensures genome stability in normal cells

To create new cells, the old cells must divide. This is a constant, frequent, and pervasive process that begins with conception and culminates with death.

30 Nov 2022

Importance of localizing BRCA gene mutations for ovarian cancer treatment

Mutations in the BRCA1 and BRCA2 genes, which are inherited by 1 in 400 and 1 in 800 persons, respectively, elevate the risk of various malignancies such as ovarian, breast, pancreatic, and prostate cancer considerably.

30 Nov 2022

Chemical-biological method to upcycle plastic waste into pharmacologically useful products

Plastic waste is one of the most significant ecological and economic problems of our time. In the journal Angewandte Chemie, a research team has now introduced a chemical–biological method for upcycling polyethylene waste: catalytic cleavage is used to make carboxylic diacids that are subsequently converted into pharmacologically useful natural products by genetically engineered fungi.

29 Nov 2022

Research News and Research

New 3D organoid model reveals a possible biological target for treating GEJ cancers

High-dose green tea extract may create liver damage in people with certain genetic variations

Investigating new ways to grow food in space

The analysis of pesticide residues in cannabis and hemp products

Preventing protein-protein interactions with a new tool

Specific genetic variant resulting in the early onset of epilepsy identified

Revealing the unappreciated role of POLQ in responding to DNA replication stress

Research could advance our understanding of evolution and the origins of cell motility

Three-year interval appropriate between screening for colorectal cancer

Nitrogen metabolism adaptations allowed marine cyanobacteria to survive in the ocean

Bats use distinct laryngeal structures to generate echolocation and social calls

Using nanotechnology and magnetic manipulations to bioengineer 3D neural networks

Acute infection disrupts the healthy balance between the good and bad gut microbes

Insight into the treatment for Crimean Congo Hemorrhagic Fever Virus

Revealing the mechanism that ensures genome stability in normal cells

Importance of localizing BRCA gene mutations for ovarian cancer treatment

Chemical-biological method to upcycle plastic waste into pharmacologically useful products

Phosphorous "loading" after a storm sparks algae explosions

Discovery provides insights into how invertebrates have evolved complex nervous systems

Deubiquitinating enzymes vital for endosomal transport identified

Genome Editing Has A New Code

Researchers reveal key developmental difference between the brains of modern humans and Neandertals

Cell Counting Without Slides to Reduce Waste and Cost

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