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Unraveling the Complexities of X Chromosome Inheritance

A new study published in Nature Genetics by the Lymphoid Development Group at the MRC Laboratory of Medical Sciences has reveals that the contribution of cells expressing maternal or paternal X chromosomes can be selectively skewed in different parts of the body.

26 Jul 2024

Advancing Cancer Drug Discovery: The Enduring Value of Phenotypic Screening

The niche areas in which phenotypic screening continues to be advantageous over the targeted approach, and the recent advances in phenotypic screening technology that have increased their efficiency.

26 Jul 2024

Antisense Therapy Shows Promise Against Parkinson's

Parkinson's disease (PD), as well as many other neurodegenerative disorders, has shown a link between the abnormal aggregation of a protein called α-synuclein (aSyn) and neuronal death. These aggregates, known as Lewy bodies and Lewy neurites depending on their subcellular localization, can spread by continuously causing normal endogenous aSyn to misfold.

26 Jul 2024

Researchers Discover How Common Bacteria can Accelerate Wound Closure in Diabetics

There are many important reasons for keeping cuts and sores clean, but new research from the Perelman School of Medicine at the University of Pennsylvania shows that a certain bug, Alcaligenes faecalis (A. faecalis), can facilitate healing of hard-to-treat wounds among people with diabetes.

26 Jul 2024

New Insights into the Neural Mechanisms Underlying Infant Attachment

Specific neurons in the brain's zona incerta (ZI) play a crucial role in the early social interactions of an infant and its mother, building their bond and reducing stress, according to a new study in mice. Activation of the same neurons in adult mice increased anxiety- and fear-like responses, the study showed.

26 Jul 2024

Cost-Effective Array Sheds Light on Imprinted Gene Regulation

Researchers from North Carolina State University have developed an array that assesses methylation levels of genes located in imprint control regions (ICRs) within the human genome. The array represents a cost-effective, efficient method for exploring potential links between environmental exposures and epigenetic dysregulation during the early developmental origins of diseases and behavioral disorders.

26 Jul 2024

New Insights into the Mechanisms of Gene Misbehavior

Researchers have discovered that a startlingly widespread occurrence in the healthy human population is "gene misbehavior," or the state in which genes are active when they should be inactive.

25 Jul 2024

Researchers Discover Genes Key to Spitting Cobra Venom's Cytotoxicity

Functional genomics to dissect and understand the cytotoxicity of spitting cobra venom and define the genetic interactions between the venom and the target to develop a locally acting antidote.

25 Jul 2024

Probing Plasma Membrane Dynamics with Cryo-Electron Microscopy

Cell membranes play a crucial role in maintaining the integrity and functionality of cells. However, the mechanisms by which they perform these roles are not yet fully understood.

25 Jul 2024

Study Reveals Titin Mutation Effects on Cardiac Development and Atrial Fibrillation

Millions of adults have atrial fibrillation -; an irregular beating of the upper chambers of the heart that yields increased risk of heart failure, stroke and death.

25 Jul 2024

NanoRanger Offers Rapid, Precise Diagnosis for Genetic Diseases

An effective long-read sequencing method that looks for intricate genomic variations can quickly and accurately diagnose genetic disorders molecularly.

24 Jul 2024

Macrolones Offer Promising Strategy for Combating Resistant Bacteria

New research from the University of Illinois Chicago suggests that a novel antibiotic that disrupts two distinct cellular targets would make it 100 million times harder for bacteria to evolve resistance.

24 Jul 2024

Understanding Gibberellin's Dual Role in Legume Nodule Development

Researchers at the University of Cambridge demonstrate that the plant hormone gibberellin (GA) is essential for the formation and maturation of nitrogen-fixing root nodules in legumes and can also increase nodule size.

24 Jul 2024

Oligodendrocytes as Producers of Amyloid Beta in Alzheimer's Disease

Oligodendrocytes are an important source of amyloid beta (Aβ) and play a key role in promoting neuronal dysfunction in Alzheimer's disease (AD), according to a study published July 23, 2024 in the open-access journal PLOS Biology by Rikesh Rajani and Marc Aurel Busche from the UK Dementia Research Institute at University College London, and colleagues.

24 Jul 2024