Schizophrenia is a chronic debilitating disorder which affects more than two million Americans, and millions more worldwide. While significant progress has been made in understanding the disease and developing treatments, there remains a significant unmet medical need. More than 50% of patients switch their medication in a given year due to either poor response or the experience of adverse events.
Artificial intelligence can increase the effectiveness of drug repositioning or repurposing research, according to a study published in Translational Psychiatry.
Researchers performed a study in which they created a total of 168 new maps of chemical marks on DNA strands, known as methylation, in developing mice.
UMass Medical School researchers Zhiping Weng, PhD, and Jill Moore, PhD, and MD/PhD students Michael Purcaro and Henry Pratt are lead authors on the latest publication of data from the ambitious ENCODE project.
At the University of Texas Health Science Center, scientists have identified a new group of proteins that guard synapses against damage.
Some individuals love meeting new people, while others abhor the idea. For individuals with conditions such as autism, unfamiliar social interactions can produce negative emotions such as fear and anxiety.
Researchers at the University of Colorado School of Medicine have identified how specific brain cells interacting during development could be related to neurological and neuropsychiatric diseases, including some that occur later in life.
For the first time, researchers in the lab of CSHL Professor Hiro Furukawa have been able to track each atom in the NMDA receptor, an important brain protein, as it transmits or inhibits neural signals.
After examining the genes of more than 200,000 people all over the world who have type-2 diabetes, researchers from the Perelman School of Medicine at the University of Pennsylvania and the Veterans Health Administration's Corporal Michael J. Crescenz Veterans Affairs Medical Center found hundreds of genetic variants never before linked to the disease.
Researchers have identified two brain phenomena that may explain some of the side-effects of ketamine. Their measurements of the brain waves of sheep sedated by the drug may explain the out-of-body experience and state of complete oblivion it can cause.
Dopamine, a chemical that sends messages between different parts of the brain and body, plays a key role in a variety of diseases and behaviors by interacting with receptors on cells.
A new synthetic molecule selectively reduces the physiological rewards of cocaine in mice.
In recent years, genome-wide association studies have identified many different genetic variants associated with schizophrenia.
The discovery of a huge number of long non-protein coding RNAs, aka lncRNAs, in the mammalian genome was a major surprise of the recent large-scale genomics projects.
The human gut microbiota consists of bacteria, fungi, and viruses constituting an inner chemical factory producing a multitude of microbial compounds.
Australian researchers have revealed for the first time that males infected with the Toxoplasma parasite can impact their offspring's brain health and behavior.
Biophysicists from the Moscow Institute of Physics and Technology and the University of Groningen in the Netherlands have visualized a nearly complete transport cycle of the mammalian glutamate transporter homolog from archaea.
Most of the research focused on the genetics of schizophrenia has aimed at understanding the function played by genes in the development and heritability of schizophrenia.
Most research about the genetics of schizophrenia has sought to understand the role that genes play in the development and heritability of schizophrenia.
In a study published recently in the eLife journal, researchers have reported that the combined effects of rare and damaging mutations that occur at birth itself have adverse effects on health span and longevity.
The prefrontal cortex of the human brain experiences a wider spectrum of developmental activity right from early prenatal development until childhood.