Schizophrenia is a chronic debilitating disorder which affects more than two million Americans, and millions more worldwide. While significant progress has been made in understanding the disease and developing treatments, there remains a significant unmet medical need. More than 50% of patients switch their medication in a given year due to either poor response or the experience of adverse events.
The brain encodes information collected by our senses. However, to perceive our environment and to constructively interact with it, these sensory signals need to be interpreted in the context of our previous experiences and current aims.
In the orchestra of the brain, the firing of each neuron is controlled by two notes--excitatory and inhibitory-- that come from two distinct forms of a cellular structure called synapses.
A large international consortium led by scientists at Uppsala University and the Broad Institute of MIT and Harvard has sequenced the genome of 130 mammals and analyzed the data together with 110 existing genomes to allow scientist to identify which are the important positions in the DNA.
In the synapses of nerve cells (neurons), there are hundreds of specialized proteins that are important for the functioning of the nervous system. If something goes wrong here, neurological or psychiatric diseases can be the result - Alzheimer's and Parkinson's, depression, and schizophrenia are just a few of them.
University of New Mexico researchers who combed through a "library" of previously approved drugs believe they have identified a medication with the potential to help speed a patient's recovery from SARS-CoV-2 infection.
Who are we? Where did we come from? How did we get here? Throughout the ages, humans have sought answers to these questions, pursuing wisdom through religion, philosophy, and eventually science.
Humans, like other animals, have the ability to constantly adapt to new situations. Researchers at the Brain Research Institute of the University of Zurich have utilized a mouse model to reveal which neurons in the brain are in command in guiding adaptive behavior.
According to neuroscientists, misfiring brain cells that regulate vital parts of the tongue and mouth might be creating swallowing problems in kids.
Scientists have identified a novel mechanism that is responsible for causing the abnormal development of neuronal connections in the mice brain.
Alicyclic compounds are groups of organic chemical compounds that have led to the development of a number of medications.
Transgender and gender-diverse adults are three to six times more likely as cisgender adults (individuals whose gender identity corresponds to their sex assigned at birth) to be diagnosed as autistic, according to a new study by scientists at the University of Cambridge's Autism Research Centre.
A new study led by NorthShore University HealthSystem (NorthShore) and the University of Chicago took a novel approach to identifying SNPs influencing the risk of neuropsychiatric disorders like schizophrenia, bipolar and major depressive disorder, the institutions announced today.
Artificial intelligence can increase the effectiveness of drug repositioning or repurposing research, according to a study published in Translational Psychiatry.
Researchers performed a study in which they created a total of 168 new maps of chemical marks on DNA strands, known as methylation, in developing mice.
UMass Medical School researchers Zhiping Weng, PhD, and Jill Moore, PhD, and MD/PhD students Michael Purcaro and Henry Pratt are lead authors on the latest publication of data from the ambitious ENCODE project.
At the University of Texas Health Science Center, scientists have identified a new group of proteins that guard synapses against damage.
Some individuals love meeting new people, while others abhor the idea. For individuals with conditions such as autism, unfamiliar social interactions can produce negative emotions such as fear and anxiety.
Researchers at the University of Colorado School of Medicine have identified how specific brain cells interacting during development could be related to neurological and neuropsychiatric diseases, including some that occur later in life.
For the first time, researchers in the lab of CSHL Professor Hiro Furukawa have been able to track each atom in the NMDA receptor, an important brain protein, as it transmits or inhibits neural signals.
After examining the genes of more than 200,000 people all over the world who have type-2 diabetes, researchers from the Perelman School of Medicine at the University of Pennsylvania and the Veterans Health Administration's Corporal Michael J. Crescenz Veterans Affairs Medical Center found hundreds of genetic variants never before linked to the disease.