Schizophrenia is a chronic debilitating disorder which affects more than two million Americans, and millions more worldwide. While significant progress has been made in understanding the disease and developing treatments, there remains a significant unmet medical need. More than 50% of patients switch their medication in a given year due to either poor response or the experience of adverse events.
An interdisciplinary team led by KU Leuven and Stanford has identified 76 overlapping genetic locations that shape both our face and our brain.
A new genetic mutation has been discovered in schizophrenia, and we spoke to Dr. Todd Lencz from the Feinstein Institutes for Medical Research to find out more.
For a long time, researchers have attempted to gain better insights into the development of the cerebral cortex and its layers, since pathologies are associated with this process.
Serotonin, or 5-hydroxytryptamine (5-HT), is a kind of neurotransmitter. 5-HT can regulate multifaceted physiological functions such as mood, cognition, learning, memory, and emotions through 5-HT receptors.
According to an analysis of sex variations in the genetics of bipolar disorder, schizophrenia, and major depressive disorders.
Scientists have suspected mutations in a cellular cholesterol transport protein are associated with psychiatric disorders, but have found it difficult to prove this and to pinpoint how it happens.
Developing brains constantly sprout new neuronal connections called synapses as they learn and remember. Important connections — the ones that are repeatedly introduced, such as how to avoid danger — are nurtured and reinforced, while connections deemed unnecessary are pruned away.
Organoids are tissues that look like organs and are extracted from stem cells cultured in laboratories. They are usually known as miniature organs.
The brain encodes information collected by our senses. However, to perceive our environment and to constructively interact with it, these sensory signals need to be interpreted in the context of our previous experiences and current aims.
In the orchestra of the brain, the firing of each neuron is controlled by two notes--excitatory and inhibitory-- that come from two distinct forms of a cellular structure called synapses.
A large international consortium led by scientists at Uppsala University and the Broad Institute of MIT and Harvard has sequenced the genome of 130 mammals and analyzed the data together with 110 existing genomes to allow scientist to identify which are the important positions in the DNA.
In the synapses of nerve cells (neurons), there are hundreds of specialized proteins that are important for the functioning of the nervous system. If something goes wrong here, neurological or psychiatric diseases can be the result - Alzheimer's and Parkinson's, depression, and schizophrenia are just a few of them.
University of New Mexico researchers who combed through a "library" of previously approved drugs believe they have identified a medication with the potential to help speed a patient's recovery from SARS-CoV-2 infection.
Who are we? Where did we come from? How did we get here? Throughout the ages, humans have sought answers to these questions, pursuing wisdom through religion, philosophy, and eventually science.
Humans, like other animals, have the ability to constantly adapt to new situations. Researchers at the Brain Research Institute of the University of Zurich have utilized a mouse model to reveal which neurons in the brain are in command in guiding adaptive behavior.
According to neuroscientists, misfiring brain cells that regulate vital parts of the tongue and mouth might be creating swallowing problems in kids.
Scientists have identified a novel mechanism that is responsible for causing the abnormal development of neuronal connections in the mice brain.
Alicyclic compounds are groups of organic chemical compounds that have led to the development of a number of medications.
Transgender and gender-diverse adults are three to six times more likely as cisgender adults (individuals whose gender identity corresponds to their sex assigned at birth) to be diagnosed as autistic, according to a new study by scientists at the University of Cambridge's Autism Research Centre.
A new study led by NorthShore University HealthSystem (NorthShore) and the University of Chicago took a novel approach to identifying SNPs influencing the risk of neuropsychiatric disorders like schizophrenia, bipolar and major depressive disorder, the institutions announced today.