Butyrate and propionate are two important short-chain fatty acids (SCFAs) produced in the human gut. They have been shown to have significant immune system effects in the intestinal mucosa, by inducing the differentiation of T-regulatory cells via inhibition of histone deacetylase (HDAC). This enzyme keeps chromatin from unwinding and, therefore, inhibits gene transcription.
Alzheimer's disease is the most common cause of dementia. Still incurable, it directly affects nearly one million people in Europe, and indirectly millions of family members as well as society as a whole.
Mice study has revealed a formerly unknown interaction between an immune cell protein and molecules extracted from dietary fiber.
A common food additive, recently banned in France but allowed in the U.S. and many other countries, was found to significantly alter gut microbiota in mice, causing inflammation in the colon and changes in protein expression in the liver, according to research led by a University of Massachusetts Amherst food scientist.
Particularly in females with untreated hypertension, reducing salt intake to what's considered a healthier level appears to be good for both their gut microbiome and their blood pressure, scientists report.
Biological engineers from Massachusetts Institute of Technology (MIT) have developed a multi-tissue model that allows them to analyze the associations between the immune system and different organs, on a dedicated microfluidic platform embedded with human cells.