Transcription Factors News and Research

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Novel Mechanism of mRNA Transfer via Tunneling Nanotubes Discovered

Cell-to-cell communication is crucial in all forms and stages of life, and various communication mechanisms have been extensively researched.

20 Feb 2025

EpiBERT AI Model Reveals How Genes Are Regulated in Human Cells

A team of investigators from Dana-Farber Cancer Institute, The Broad Institute of MIT and Harvard, Google, and Columbia University have created an artificial intelligence model that can predict which genes are expressed in any type of human cell.

30 Jan 2025

GET Model Unveils Gene Regulation with Unmatched Accuracy Across Cell Types

GET, a novel computational model, accurately predicts gene activity by analyzing chromatin accessibility and DNA sequences across diverse human cell types.

20 Jan 2025

Plant Research Reveals Unexpected Function for Key Cellular Protein

A cell protein previously believed only to provide a scaffolding for DNA has also been shown to directly influence DNA transcription into RNA – the first step of the process by which an organism's genetic code expresses itself. The fundamental breakthrough was discovered in apple cells but is relevant to all living organisms made of nucleus-containing cells, including humans.

24 Dec 2024

Discovery of START Domain Reveals Secrets of Plant Development

Within all complex, multicellular living systems such as plants and humans, there exists a set of genetic elements that can be likened to the blueprints, tools, and specialized personnel at a construction site for an expanding development.

6 Dec 2024

Cancer-Associated Gene MYC Found to Drive Muscle Growth Independently of Exercise

Researchers have long known that there is a relationship between the cancer-associated gene MYC (pronounced "Mick") and exercise adaptation.

4 Dec 2024

The Role of RNA Polymerase and Ribosomes in Gene Expression

DNA within a cell contains the genetic instructions necessary for building proteins.

29 Nov 2024

Study Reveals Molecular Mechanism Behind Neural Fate Commitment

The Wistar Institute's Alessandro Gardini, Ph.D., and lab have shed new light on how certain biological processes determine the development of neural cells. Their findings on a molecular "bridge" complex demonstrate a new level of detail in the understanding of early neural development -; which is fundamental for the further understanding of neurodevelopmental syndromes.

27 Nov 2024

Novel Mechanism Revealed for Zygotic Genome Activation in Drosophila

Early development of an embryo is solely supported by maternally deposited RNAs and proteins until its own genome is activated through a process called zygotic genome activation (ZGA).

20 Nov 2024

Understanding Marine Worms’ Unique Ability to Regenerate Lost Body Parts

Many living organisms are able to regenerate damaged or lost tissue, but why some are particularly good at this and others are not is not fully understood.

19 Nov 2024

The Role of Neural Crest Stem Cells in Cellular Reprogramming

Researchers at the University of Toronto have identified that neural crest stem cells, a group of cells located in the skin and other parts of the body, are the origin of reprogrammed neurons previously discovered by other scientists.

4 Nov 2024

Researchers Identify Mechanism of Immune Suppression in Ovarian Cancer

Researchers at Weill Cornell Medicine have shown that ovarian cancers disable immune cells and prevent them from attacking by cutting off the energy source that T cells rely on.

24 Oct 2024

Research Advances Understanding of Gene Expression Mechanisms

During embryonic development, cells start out as pluripotent, or have the potential to become many different cell types through differentiation.

17 Oct 2024

Study Unlocks Mechanisms Behind Nucleosome Arrays Using Signal Theory and Machine Learning

Findings show that machine learning can accurately predict nucleosome positions, emphasizing the relationship between nucleosome architecture and gene activity.

17 Oct 2024

Unveiling the Potential of YY1 in Blood Cell Development and Therapy

Common lymphoid progenitors, pre-pro-B cells, pro-B cells, pre-B cells, immature B cells, and finally more mature and specialized B cells are the stages in which B cells, white blood cells that produce antibodies, develop.

17 Oct 2024

Scientists Identify Drug-Binding Site on FOXA1

Forkhead box protein 1 (FOXA1) is a difficult-to-target protein that is frequently involved in hormone-driven malignancies, such as those of the breast and prostate.

16 Oct 2024

A Novel Function for STING in DNA Damage Response

A study published in the journal Molecular Cell has shed light on the multifaceted role of STING, a protein previously implicated in antiviral signaling pathways. The study reveals that STING also plays a crucial part in facilitating cellular stress resolution and promoting cell survival.

23 Sep 2024