Transcription Factors News and Research

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A New Approach to Understanding Enhancer-TF Interactions

Every cell in the human body has the same DNA, yet liver cells differ from brain cells, and skin cells from muscle cells.

9 Sep 2024

From Bone Regeneration to Heart Repair: Stem Cell Transplantation Paves the Way for New Medical Frontiers

Stem cell transplantation offers promising solutions for tissue regeneration and age-related degeneration, despite challenges in safety and production costs.

9 Sep 2024

New Insights into Python Cardiac Biology Could Inform Human Heart Disease Research

Study of python cardiac responses to feeding uncovers structural and epigenetic changes, enhancing understanding of heart disease and therapeutic applications.

2 Sep 2024

Breakthrough Discovery in DNA Spatial Grammar Could Reshape Gene Activity Studies

A newly discovered code within DNA – coined "spatial grammar" – holds a key to understanding how gene activity is encoded in the human genome.

21 Aug 2024

Study Reveals Mechanisms Behind Lineage Restriction in Cell Development

A team of researchers from multiple institutions including the University of Chicago and VectorBuilder, has made a significant breakthrough in the understanding of lineage restriction, a biological phenomenon foundational to multicellular lifeforms as it secures the functional identities of the myriad cell types in the body.

14 Aug 2024

Rapid Parkinson's Model Opens Door to Personalized Treatments

Scientists at Brigham and Women’s Hospital, a key member of the Mass General Brigham healthcare system, have created a model that swiftly transforms stem cells into brain cells exhibiting protein structures associated with Parkinson’s disease (PD).

30 Jul 2024

Innovative Model Creates Personalized Parkinson's Disease Brain Cells for Drug Testing

A new model developed by Brigham researchers rapidly converts stem cells to brain cells characteristic of Parkinson’s disease to create personalized stem cell models with opportunities to test treatments

29 Jul 2024

New Model Reveals Interplay Between Circadian Rhythms and Sleep-Wake Cycles in Gene Expression

A mathematical, driven, damped harmonic oscillator model to assess the varying contributions of circadian cues and sleep-wake processes on gene expression and the rhythmic transcriptome.

18 Jul 2024

Genome Assembly of Finger Lemon 'YaoJi' Reveals Genetic Underpinnings of Rind Color Differences

A research team successfully sequenced and assembled the genome of the purple finger lemon variety 'YaoJi', revealing a genome size of 314.63 Mb across nine chromosomes.

28 Jun 2024

Mapping Gene Targets of HNF4A and HNF1A in Human Pancreatic Beta Cells and Liver Cells

Scientists have generated a comprehensive map of the gene targets regulated by the transcription factors HNF4A and HNF1A in human pancreatic beta cells and liver cells.

26 Jun 2024

Primitive Endoderm Stem Cells Offer New Hope for Fertility Treatments

An unexpectedly versatile and regenerative stem cell in early embryos may be key to creating new effective fertility treatments, suggests a new study in mice from the University of Copenhagen.

25 Jun 2024

Genetic Insights into Salt Gland Formation and Stress Responses in Sea Lavender

Basic helix–loop–helix (bHLH) transcription factors are essential for various plant processes, including growth, development, and stress responses.

7 Jun 2024

CRISPR/Cas Biosensors Address Sensitivity and Specificity Challenges in Detection

The mechanisms of CRISPR-Cas-based biosensors.

5 Jun 2024

Transcriptomic Analysis Reveals Age-Dependent Gene Expression Patterns in Mouse Sweat Glands

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 8, entitled, "Characterization of age-associated gene expression changes in mouse sweat glands."

15 May 2024

Single-Molecule Study Reveals Unexpected Role of Protein Stiffness in Nuclear Transport

The degree of softness or rigidity in specific regions of proteins can affect how quickly or slowly those proteins enter the nucleus, according to research from the Francis Crick Institute and King's College London.

14 May 2024

Decoding Chromatin Modifications: A Breakthrough in Epigenome Editing

An epigenome editing platform and a method to program nine major chromatin modifications.

14 May 2024

New Tool Precisely Edits Epigenetic Modifications

Powerful epigenetic editing technology was developed as a result of research by the Hackett group at EMBL Rome. This technology allows for the precise programming of chromatin modifications.

10 May 2024

St. Jude Scientists Reveal Role of Non-Coding DNA Variants in Childhood Leukemia

St. Jude Children's Research Hospital scientists have identified specific DNA variants in the non-coding regions of the genome contributing to chemotherapy resistance in acute lymphoblastic leukemia (ALL).

2 May 2024

Small Genetic Element Identified as Key to Potato Industry's Production Problem

Researchers have discovered a game changer for the potato industry.

12 Mar 2024

Researchers Identify Proteins to Reprogram Fibroblasts into Limb Progenitor Cells

In a collaborative study, researchers from Kyushu University and Harvard Medical School have identified proteins that can turn or "reprogram" fibroblasts -; the most commonly found cells in skin and connective tissue -; into cells with similar properties to limb progenitor cells.

5 Mar 2024