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Scientists Discover New Class of Molecular Glue Degraders for Cancer Therapy

Cells contain molecular machinery that targets and disposes of unwanted proteins to maintain homeostasis.

17 Nov 2023

The Dominant Phage-Resistant LAB in Long-Term Kimchi Fermentation

Scientists from the World Institute of Kimchi have successfully extracted lactic acid bacteria (LAB) strains that exhibit remarkable phage resistance.

2 Nov 2023

New Computational Approach Efficiently Identifies Optimal Genetic Perturbations

A strategy for cellular reprogramming involves using targeted genetic interventions to engineer a cell into a new state.

3 Oct 2023

New Halophyte Genome Sequence Sheds Light on Salt Tolerance Mechanisms

A Recent study conducted by Professor Qin Yuan's team from the Center for Genomics at the Haixia Institute of Science and Technology (Future Technology College) at Fujian Agriculture and Forestry University has been published in the prestigious journal Horticulture Research, which is a leading publication in the field of horticultural science.

25 Sep 2023

Scientists Uncover New Mechanism for Degrading Short-Lived Proteins

Short-lived proteins control gene expression in cells to carry out a number of vital tasks, from helping the brain form connections to helping the body mount an immune defense. These proteins are made in the nucleus and are quickly destroyed once they've done their job.

25 Aug 2023

Researchers Lead Innovative Studies on Mammalian Aging and Life Span

Scientists at UCLA David Geffen School of Medicine and UCLA Health led an international research team that published two articles detailing changes in DNA – changes that researchers found are shared by humans and other mammals throughout history and are associated with life span and numerous other traits.

11 Aug 2023

New Insights Into How T Cells Become Exhausted in Cancer

Immune system T cells that should be able to kill cancer cells become dysfunctional or "exhausted" within hours of encountering a tumor, according to a study reported Aug. 3 in Nature Immunology.

7 Aug 2023

Lactate Signaling Found to Be Critical for Neuronal Differentiation

Scientists at Tohoku University have discovered the critical role that lactate plays in helping neural stem cells develop into specialized neurons, a process dubbed neuronal differentiation.

25 Jul 2023

The Mechanism of Immune Memory Development

The memory of the immune system depends on distinctive epigenetic traits and a particular 3D arrangement of the DNA in the nucleus of memory cells, allowing for rapid activation of these cells, according to a team of researchers from the Erasmus University Medical Center, the Centre for Genomic Regulation (CRG), and the Josep Carreras Leukaemia Research Institute.

12 Jul 2023

New Insights Into How Genes Are Activated

Genetic information contained within DNA has to be read by specific proteins that enable the process of gene activation to begin – but in many cases, these proteins can't access their targets because DNA strands are bundled up to control what genes are used in the wide range of different cell types.

12 Jul 2023

Negative Modulation of Arabidopsis Salinity Tolerance by CONSTANS Protein

Arabidopsis (Arabidopsis thaliana)’s photoperiodically controlled flowering and circadian pathways are primarily regulated by CONSTANS (CO), a well-known B-box family member.

5 Jul 2023

Trim24 Limits the Ability of p53 to Function as a Tumor Suppressor

The tumor suppressor protein p53 has been nicknamed the “guardian of the genome” because it safeguards the DNA from long-term damage or stress by controlling the expression of numerous genes involved in DNA repair, cell division, and cell death.

3 Jul 2023

New View of Euchromatin in the Cell Analyzed

In their study performed, the research group discusses their novel view of euchromatin present in the cell and displays how the disclosed organization is appropriate to genome functions.

28 Jun 2023

Cell Fate Conversion Plays Crucial Role in Cancer Research

Researchers from the Max Delbrück Center for Molecular Medicine in the Helmholtz Association in Berlin and the Centre for Genomic Regulation (CRG) in Barcelona have discovered how cells speed changes to their identity known as “cell fate conversion.”

28 Jun 2023

Analyzing the Cis-Regulatory Elements and Transcription Factors Related to Auxin Signaling

Phytohormones are chemical messengers that control the growth of plants and also their response to the environment.

27 Jun 2023

New Approach to Revolutionize Synthetic Biology

For the first time, scientists at the Lawrence Berkeley National Laboratory of the Department of Energy (Berkeley Lab) have created a genome-scale method to map the regulatory role of transcription factors, proteins that are essential for controlling gene expression, and a plant’s physiological features.

22 Jun 2023

cBAF Protein Complex Controls the Fate of T Cells

The immune system protects the body from intruders, like bacteria, viruses, or tumors, with its intricate network of proteins, cells, and organs. Cytotoxic T cells are specialized immune cells that can grow into short-lived effector cells that destroy infected or malignant cells in human bodies.

14 Jun 2023