Transplant News and Research

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Researchers uncover a new cellular mechanism for disposing of misfolded proteins

About 30 years ago, Dr. Richard Sifers set out on a journey to discover why people with a rare condition known as alpha1-antitrypsin (AAT) deficiency present with high variation in the severity of liver disease.

21 Oct 2020

Stem cells that promote bone repair can also generate arthritic bone spurs

The same stem cells that heal broken bones can also generate arthritic bone spurs called osteophytes, according to a new study in the Annals of the Rheumatic Diseases.

13 Oct 2020

Immune cell biomarker may help identify patients at risk for graft-versus-host disease

A recent report published in Science Translational Medicine by MUSC Hollings Cancer Center investigator Sophie Paczesny, M.D., Ph.D., sheds light on immune cell biomarkers that may reveal which patients are most at risk for graft-versus-host disease (GVHD), a life-threatening condition that can arise after hematopoietic stem cell transplantation (HSCT) for treatment of liquid cancers such as leukemia.

8 Oct 2020

Microneedles For Therapeutic Gene Delivery

There is great potential in gene therapy for treating certain types of cancer and genetic defects, immunological diseases, wounds and infections.

7 Oct 2020

Researchers map genetic networks controlling human regulatory T cell identity

Unlike most T cells, which launch immune responses against foreign molecules, regulatory T cells are the peacekeepers of the human immune system, damping down inflammatory reactions when they're not needed.

5 Oct 2020

New method delivers promising anti-rejection drug to area surrounding a grafted heart

For patients who receive a heart transplant in the near future, the old adage, "Good things come in small packages," may become words to live by.

4 Sep 2020

Shielded stem cells can improve heart healing

Ghanta, R.K., et al. (2020) Immune-modulatory alginate protects mesenchymal stem cells for sustained delivery of reparative factors to ischemic myocardium. Biomaterials Science. doi.org/10.1039/D0BM00855A.

19 Aug 2020

Combination regimen improves overall survival in acute myeloid leukemia patients

A combination regimen of venetoclax and azacitidine was safe and improved overall survival (OS) over azacitidine alone in certain patients with acute myeloid leukemia (AML), according to the Phase III VIALE-A trial led by The University of Texas MD Anderson Cancer Center.

13 Aug 2020

Clinical trial shows CAR-T cell therapy can be used for treating Hodgkin lymphoma

CAR-T cell therapy, which attacks cancer cells using a person's reprogrammed immune cells, has been used to treat Hodgkin lymphoma with remarkable success for the first time, according to the results of an early phase clinical trial led by researchers at UNC Lineberger Comprehensive Cancer Center and Baylor College of Medicine in Houston.

24 Jul 2020

Stem cell treatment could improve the quality of donor kidneys

New research has demonstrated that kidneys can be revived prior to transplantation by delivering a cell therapy directly to the organ.

From Newcastle University 15 Jul 2020

Researchers explore the reproduction of adenoviruses in cells

An adenovirus infection can be potentially life-threatening, especially for children after a stem cell transplant.

14 Jul 2020

Severely injured donor lungs can be recovered using cross-circulation platform

Respiratory disease is the third leading cause of death worldwide, and lung transplantation is still the only cure for patients with end-stage lung disease.

14 Jul 2020

Scientists discover new antiviral drug against paramyxovirus

A new antiviral drug that is effective against a broad range of human pathogens in the paramyxovirus family, such as the human parainfluenzaviruses and measles virus, has been discovered by researchers in the Institute for Biomedical Sciences at Georgia State University.

14 Jul 2020

In vitro cardiotoxicity screening using 3D-printed human heart tissues

Ramot at Tel Aviv University has signed a collaboration agreement with Bayer to develop and validate a platform for in vitro cardiotoxicity screening, using human heart tissues 3D-printed in Prof. Tal Dvir's Laboratory for Tissue Engineering and Regenerative Medicine at Tel Aviv University.

1 Jul 2020

Foodborne titanium dioxide nanoparticles impact gut microbiota in mice

A common food additive, recently banned in France but allowed in the U.S. and many other countries, was found to significantly alter gut microbiota in mice, causing inflammation in the colon and changes in protein expression in the liver, according to research led by a University of Massachusetts Amherst food scientist.

26 Jun 2020

Whole genome sequencing can improve rare disease diagnosis

A research programme pioneering the use of whole genome sequencing in the NHS has diagnosed hundreds of patients and discovered new genetic causes of disease.

25 Jun 2020

Developments in Engineered T Cells for Type 1 Diabetes

AZoLifeSciences speaks to Professor David J. Rawlings from the Seattle children's hospital about recent developments in engineered T cells for type 1 diabetes.

23 Jun 2020

Microneedle depots effectively deliver stem cells into damaged tissues

Mesenchymal stem cells are multipotent in that they naturally replenish the cell types that build our bone, cartilage and adipose tissues.

10 Jun 2020

Coronavirus attacking microRNA numbers reduce with age

A group of tiny RNA that should attack the virus causing COVID-19 when it tries to infect the body are diminished with age and chronic health problems, a decrease that likely helps explain why older individuals and those with preexisting medical conditions are vulnerable populations, investigators report.

14 May 2020

Mice study identifies protein vital for liver restoration and regeneration after hepatic surgery

Researchers from the Faculty of Medicine of the University of Barcelona and the CELLEX Biomedical Research Centre from IDIBAPS have identified in a study with mice a protein which is fundamental to guarantee the restoration and regeneration of the liver after a transplant or hepatic surgery.

12 May 2020

Transplant News and Research

Researchers uncover a new cellular mechanism for disposing of misfolded proteins

Stem cells that promote bone repair can also generate arthritic bone spurs

Immune cell biomarker may help identify patients at risk for graft-versus-host disease

Microneedles For Therapeutic Gene Delivery

Researchers map genetic networks controlling human regulatory T cell identity

New method delivers promising anti-rejection drug to area surrounding a grafted heart

Shielded stem cells can improve heart healing

Combination regimen improves overall survival in acute myeloid leukemia patients

Clinical trial shows CAR-T cell therapy can be used for treating Hodgkin lymphoma

Stem cell treatment could improve the quality of donor kidneys

Researchers explore the reproduction of adenoviruses in cells

Severely injured donor lungs can be recovered using cross-circulation platform

Scientists discover new antiviral drug against paramyxovirus

In vitro cardiotoxicity screening using 3D-printed human heart tissues

Foodborne titanium dioxide nanoparticles impact gut microbiota in mice

Whole genome sequencing can improve rare disease diagnosis

Developments in Engineered T Cells for Type 1 Diabetes

Microneedle depots effectively deliver stem cells into damaged tissues

Coronavirus attacking microRNA numbers reduce with age

Mice study identifies protein vital for liver restoration and regeneration after hepatic surgery

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