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INTEGRA supports groundbreaking brain tumor research

INTEGRA Biosciences is proud to be supporting vital translational research into diffuse intrinsic ponsglioma (DIPG) – a rare childhood brain tumor – at the Ludwig Maximilian University of Munich (LMU) with a festive donation of 20,000 EUR.

From INTEGRA Biosciences 21 Dec 2021

Driving up the immune response at tumor site may help boost immunotherapy

Driving up the immune response at the site of a cancer tumor with nanotechnology may help enhance immunotherapy treatments in advanced stages of the disease, new research in mice suggests.

15 Dec 2021

Scientists find how cells remain dormant for years before awakening to create metastatic cancer

Mount Sinai researchers have solved a major mystery in cancer research: How cancer cells remain dormant for years after they leave a tumor and travel to other parts of the body, before awakening to create metastatic cancer.

14 Dec 2021

Study illustrates the concept of cool microscopy

Fluorescence light microscopy has the unique ability to observe cellular processes over a scale that bridges four orders of magnitude. Yet, its application to living cells is fundamentally limited by the very rapid and unceasing movement of molecules that define its living state.

From The Max Planck Institute 14 Dec 2021

Genetic makeup of neuroblastoma shows marked spatial and temporal variability

Tumors are heterogeneous, which means that different parts of the same tumor can be genetically distinct. This phenomenon, known as intratumor heterogeneity, is steadily gaining in significance within the field of cancer research.

13 Dec 2021

Study helps identify how immune system cells identify and eradicate tumors

In the last 10 years, immunotherapy has been used to save the lives of several cancer patients with lung cancer.

13 Dec 2021

New classification method divides breast cancers into 12 distinct biological groups

Researchers at UNC Lineberger Comprehensive Cancer Center have taken a major step forward in melding two key methods for studying breast cancer: one by genetic analysis and the second by looking at the architecture of cells, or their pathology.

9 Dec 2021

Single-cell spatial analysis may provide information about neoadjuvant therapy for triple-negative breast cancer

A next-generation technology that allows the study of protein expression at the single-cell level and the location of the cells within the tumor microenvironment (TME) was feasible and provided information on the benefit of adding the immune checkpoint inhibitor atezolizumab (Tecentriq) to chemotherapy as neoadjuvant treatment for patients with early high-risk and locally advanced triple negative breast cancer (TNBC), according to results presented at the San Antonio Breast Cancer Symposium, held December 7-10, 2021.

8 Dec 2021

New strategy to improve the therapeutic efficacy of liver cancer immunotherapy

In recent years, tumor immunotherapy has emerged as a highly promising and much-touted oncological approach.

8 Dec 2021

Next-generation sequencing for minimal residual disease proven more sensitive than flow cytometry

In pediatric and young adult patients with acute lymphoblastic leukemia (ALL) treated with tisagenlecleucel (Kymriah), DNA sequencing-based detection of residual disease between three and 12 months accurately identified all patients who would eventually relapse, while other methods were less predictive.

2 Dec 2021

Study identifies genes that protect ovarian cancer from antitumor immunity

Immunotherapies are exhibiting better clinical benefit in the treatment of numerous cancers, particularly when used along with chemotherapy.

2 Dec 2021

Study finds amphipathic peptide that safely opens endosomal membrane

The cell plasma membrane and the derived endosomal membranes are both greasy barriers that prevent the inflow of water-soluble macromolecules like nucleic acids and proteins into cells.

2 Dec 2021

Introducing the PhysioMimix™ OOC Multi-Organ Microphysiological System

CN Bio, a leading developer of single and multi-organ microphysiological systems (MPS), otherwise known as organ-on-a-chip (OOC), today announced the commercial launch of its new PhysioMimix™ OOC Multi-Organ MPS.

From CN Bio Innovations Limited 1 Dec 2021

Researchers show that tumor cells contribute differently to the formation of metastases

A type of cell transformation known as EMT enables cancer cells to break away from the tumor and form metastases elsewhere.

30 Nov 2021

Treatment with common allergy medication linked to improved immunotherapy response

New research from The University of Texas MD Anderson Cancer Center found that treatment with antihistamines, a commonly used allergy medication, was associated with improved responses to immune checkpoint inhibitors.

29 Nov 2021

Novel therapeutic approach forces cancer cells to dormancy, prevents metastasis

A novel therapeutic approach inhibits the growth of metastatic tumors in mice by coercing cancer cells into a dormant state—where they cannot proliferate.

25 Nov 2021

Regulating the activity of a protein enhances health span, says research

Scientists from KAIST put forth novel insights for enhancing the health span by controlling a protein’s activity.

25 Nov 2021

Study identifies key proteins that damage skin cells in psoriasis

Psoriasis is an autoimmune disease that is characterized by patches of red, inflamed skin and painful, scaly rashes.

25 Nov 2021

UD biochemist explores how mRNA eraser enzymes work in our cells

University of Delaware biochemist Jeff Mugridge is trying to figure out how so-called mRNA eraser enzymes work in our cells, why those erasers can sometimes misbehave and lead to cancer, and how science can pave the way for possible solutions to this problem.

25 Nov 2021

MIT researchers identify a way to indirectly activate T cells to fight tumors

Under the right circumstances, the body's T cells can detect and destroy cancer cells. However, in most cancer patients, T cells become disarmed once they enter the environment surrounding a tumor.

22 Nov 2021

Tumor News and Research

INTEGRA supports groundbreaking brain tumor research

Driving up the immune response at tumor site may help boost immunotherapy

Scientists find how cells remain dormant for years before awakening to create metastatic cancer

Study illustrates the concept of cool microscopy

Genetic makeup of neuroblastoma shows marked spatial and temporal variability

Study helps identify how immune system cells identify and eradicate tumors

New classification method divides breast cancers into 12 distinct biological groups

Single-cell spatial analysis may provide information about neoadjuvant therapy for triple-negative breast cancer

New strategy to improve the therapeutic efficacy of liver cancer immunotherapy

Next-generation sequencing for minimal residual disease proven more sensitive than flow cytometry

Study identifies genes that protect ovarian cancer from antitumor immunity

Study finds amphipathic peptide that safely opens endosomal membrane

Introducing the PhysioMimix™ OOC Multi-Organ Microphysiological System

Researchers show that tumor cells contribute differently to the formation of metastases

Treatment with common allergy medication linked to improved immunotherapy response

Novel therapeutic approach forces cancer cells to dormancy, prevents metastasis

Regulating the activity of a protein enhances health span, says research

Study identifies key proteins that damage skin cells in psoriasis

UD biochemist explores how mRNA eraser enzymes work in our cells

MIT researchers identify a way to indirectly activate T cells to fight tumors

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