in vivo News and Research

RSS

Study reveals possibility of changing the identity of synapses through enzymatic means

As you're reading this sentence, the cells in your brain, called neurons, are sending rapid-fire electrical signals between each other, transmitting information.

14 Jun 2022

OTUD3 shows opposing effects in innate immunity to RNA and DNA viruses

The identification of pathogen-associated molecular patterns (PAMPs) by pattern-recognition receptors (PRRs) is the first step in initiating an immune response to viral infection.

13 Jun 2022

ZDHHC18-mediated MDH2 palmitoylation upholds mitochondrial respiration and boosts ovarian cancer malignancy

To drive anabolic processes, epithelial ovarian cancer (EOC) is heavily reliant on the tricarboxylic acid (TCA) cycle and oxidative phosphorylation.

13 Jun 2022

Researchers discover a new interferon-gamma receptor signaling pathway

The interferon-gamma receptor (IFNgR) signaling pathway has been identified to be crucial for the vulnerability of glioblastoma tumors to death by CAR T-cell immunotherapy, according to researchers at Massachusetts General Hospital (MGH).

10 Jun 2022

Researchers analyze functional microglia to empower retinal organ

Professor Zi-Bing Jin is in charge of this research (Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, and Capital Medical University). He has spent the last decade working on retinal organoids, which can accurately mimic retinal development.

3 Jun 2022

Researchers analyze the chemical and biophysical properties of protein corona

Professor Chunying Chen of the Chinese Academy of Sciences’ (CAS) National Center for Nanoscience and Technology (NCNST) has been studying the chemical and biophysical characteristics of protein corona in nanomedicine.

3 Jun 2022

Researchers create human cornea-on-a-chip to check the therapeutic effect of MSC exosomes on corneal disorders

Ophthalmologists and researchers have been looking into mesenchymal stem cells (MSCs) with regenerative and differentiation capacities as a potential therapy option for corneal disorders.

30 May 2022

Scientists demonstrate how stomach stem cells switch from one state to the other upon injury

A stomach adult stem cell population can fulfill two distinct functions: either help with digestion under normal conditions or take the lead on injury response. S

26 May 2022

Study shows polymersome can effectively deliver PARP1 siRNA to treat breast cancer

Small interfering RNAs, or siRNAs, have the potential to cure tumors by targeting knocking down oncogenes that drive tumor development while avoiding the damage associated with chemotherapy.

25 May 2022

Researchers develop primitive endoderm stem cells in mice

RIKEN scientists have extracted and grown stem cells that give way to the mouse yolk sac for the first time in the laboratory, boosting the potential of generating mouse embryos from stem cells in the coming years.

23 May 2022

New research identifies a destination for zinc chaperone protein's deliveries

Most people don't think much about zinc. But all living things need zinc for survival. This trace element helps many proteins fold into the right shapes to do their jobs.

18 May 2022

New supramolecular CRISPR–Cas9 carrier supports much effective genome editing

Clustered regularly interspaced short palindromic repeats (CRISPR) and their accompanying protein, CRISPR-associated protein 9 (Cas9), several years ago, made international news as a game-changing genome editing system.

18 May 2022

Researchers highlight a phage-antibiotic combo against antibiotic-resistant superbug

A preclinical study performed by Monash University researchers discovered that utilizing a combination of phages and antibiotics to treat bacterial infections may be considerably more successful than using the drugs separately.

12 May 2022

Study shows new potential target for CAR T cells to inhibit solid tumors

CAR T therapy, or chimeric antigen receptor T-cell therapy, has revolutionized the treatment of some blood cancers, allowing patients with relapsed or refractory disease to live longer and better lives.

10 May 2022

CN Bio introduces PhysioMimix NASH ‘in-a-box’ reagent kit

First product within new ‘in-a-box’ range, which harnesses next-generation, human-relevant Liver-on-a-Chip technology to improve the accuracy and efficiency of NASH drug discovery.

From CN Bio Innovations Limited 26 Apr 2022

Study identifies novel targets for treating sorafenib-resistant hepatocellular carcinoma

Research headed by Professor Xiujun Cai used the CRISPR/cas9 system to screen the entire genome of hepatocellular carcinoma cells (HepG2) under sorafenib treatment.

25 Apr 2022

Encapsulated peptide could provide a new approach to fighting bacterial infections

Antibiotic-resistant hospital pathogens are not to be underestimated as a health risk. A research team has now introduced a new approach for treating multiple-drug resistant Staphylococcus in the journal Angewandte Chemie.

21 Apr 2022

Study identifies new targets for treating sorafenib-resistant hepatocellular carcinoma using CRISPR-Cas9 screening

This study is led by Xiujun Cai (Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University School of Medicine). Professor Xiujun Cai's research team screened the whole genome of hepatocellular carcinoma cells (HepG2) through CRISPR / cas9 system under sorafenib treatment, and screened the dominant gene in sorafenib resistance.

20 Apr 2022

Stem cell-mediated gene therapy technique helps to boost bone regeneration

Mesenchymal stem cell-derived exosomes (MSC-Exo) have gained a lot of attention due to their “cell-free” treatments.