Alzheimer's disease (AD) is an irreversible, progressive brain disease that slowly destroys memory and thinking skills and, eventually, the ability to carry out the simplest tasks of daily living. In most people with AD, symptoms first appear after age 60. AD is the most common cause of dementia among older people, but it is not a normal part of aging. Dementia refers to a decline in cognitive function that interferes with daily life and activities. AD starts in a region of the brain that affects recent memory, then gradually spreads to other parts of the brain. Although treatment can slow the progression of AD and help manage its symptoms in some people, currently there is no cure for this devastating disease.
An interdisciplinary team led by KU Leuven and Stanford has identified 76 overlapping genetic locations that shape both our face and our brain.
Scientists from the University of Leeds's Nutritional Epidemiology Group used data from 500,000 people, discovering that consuming a 25g serving of processed meat a day, the equivalent to one rasher of bacon, is associated with a 44% increased risk of developing the disease.
On the basis of a license agreement with the German Center for Neurodegenerative Diseases (DZNE) and the Leibniz Institute of Polymer Research Dresden (IPF), the Dresden-based start-up "Neuron-D GmbH" is developing a high-throughput system for testing drug candidates to treat neurodegenerative diseases.
A study published in the journal eLife made all the possible mutations in the amyloid beta peptide and tested how they influence its aggregation into plaques, a pathological hallmark of Alzheimer's disease.
AZoLifeSciences speaks to researchers from Tianjin Medical University about their latest research that led to the discovery of two new genes that are linked to Alzheimer's disease.
Imagine if surgeons could transplant healthy neurons into patients living with neurodegenerative diseases or brain and spinal cord injuries.
Researchers at University of California San Diego School of Medicine have launched a first-in-human Phase I clinical trial to assess the safety and efficacy of a gene therapy to deliver a key protein into the brains of persons with Alzheimer's disease (AD) or Mild Cognitive Impairment (MCI), a condition that often precedes full-blown dementia.
Green tea contains an antioxidant that may boost the concentrations of p53, called the “guardian of the genome,” for its potential to kill cancerous cells.
Findings from a new study on Alzheimer's disease could eventually help clinicians identify people at the highest risk for developing the progressive brain disorder.
A research team, headed by Cleveland Clinic, has designed a novel personalized genomic medicine platform that would help speed up genomic medicine studies as well as genome-informed drug discovery. The results of the new study have been recently published in the Genome Biology journal.
Scientists have known for decades that our cells constantly shed tiny pieces known as extracellular vesicles (EVs), but until relatively recently they believed that this process was merely a way for cells to rid themselves of material that was no longer needed.
A City of Hope-led research team found that the same gene that increases the risk for Alzheimer's disease, ApoE4, can increase the susceptibility to and severity of COVID-19.
Genetics contributes to the risk of developing Alzheimer's disease, and the APOE gene is the strongest genetic risk factor, specifically the APOE4 allele.
Scientists in Japan's brain science project have used machine intelligence to improve the accuracy and reliability of a powerful brain-mapping technique, a new study reports.
Spinal cord injury (SCI) often causes disability and seriously compromises quality of life. While decades of research have made significant progress in axonal regeneration after SCI, most of the interventions have not been translated into clinical therapies.
Researchers have found how a protein governs the behavior of proteins associated with the activity in mitochondria, which is impacted in Alzheimer's disease.
An important part of the brain's immune system, cells called microglia constantly extend and retract "branches" from their cell body to survey their environment.
On a late summer day in 1953, a young man who would soon be known as patient H.M. underwent experimental surgery.
Infrared analyses of neuronal proteins provide information on molecular changes in patients with ALS. This helps to verify their diagnosis.
Michael Gross, professor of chemistry in Arts & Sciences at Washington University in St. Louis and of immunology and internal medicine at the School of Medicine, and his team are experts in footprinting proteins -- that is, using advanced methods for investigating the structure and interactions of proteins within larger molecules.