Alzheimer's Disease News and Research

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Alzheimer's disease (AD) is an irreversible, progressive brain disease that slowly destroys memory and thinking skills and, eventually, the ability to carry out the simplest tasks of daily living. In most people with AD, symptoms first appear after age 60. AD is the most common cause of dementia among older people, but it is not a normal part of aging. Dementia refers to a decline in cognitive function that interferes with daily life and activities. AD starts in a region of the brain that affects recent memory, then gradually spreads to other parts of the brain. Although treatment can slow the progression of AD and help manage its symptoms in some people, currently there is no cure for this devastating disease.

Study uses mouse models to identify the likely cause of Alzheimer's disease

Ground-breaking new Curtin University-led research has discovered a likely cause of Alzheimer's disease, in a significant finding that offers potential new prevention and treatment opportunities for Australia's second-leading cause of death.

16 Sep 2021

Researchers develop novel cell reprogramming strategy to slow down glioblastomas

Gliomas are the most common primary brain tumors in adults. Among them, high-grade glioblastomas (GBMs) are particularly known to be notoriously aggressive and invasive, which makes it challenging to treat them.

16 Sep 2021

Scientists use stem cells to investigate the genetic risk for Alzheimer's disease

AD, the most frequent cause of dementia, affects an estimated 24 million people worldwide. With very limited treatment options, scientists are looking for ways to understand the disease better.

16 Sep 2021

NYU Tandon professors show broad therapeutic potential of novel peptide to combat multiple diseases

NYU Tandon professors Mary Cowman and Jin Ryoun Kim recently published a paper describing a novel peptide with broad therapeutic potential to combat chronic inflammation in multiple diseases.

31 Aug 2021

New mouse line reveals the state of proteostasis in mammalian brain for the first time

Proteins are the "tools" of our cells – they are essential to all vital tasks. However, they are only able to do their jobs if they fold correctly and adopt their respective, very specific 3D structure.

20 Aug 2021

Study reveals how 3D space is represented in the mammalian cortex by the brain's 'GPS'

In a new study published in Nature today, Weizmann Institute of Science researchers, in collaboration with colleagues from the Hebrew University of Jerusalem, unveiled for the first time how three-dimensional space is represented in the mammalian cortex by the brain's "GPS" system.

13 Aug 2021

Muscle protein tied to physical fitness in youth and age-associated diseases

Researchers from Johns Hopkins Medicine say they have added to evidence that a protein called CaMKII improves strength, endurance, muscle health and fitness in young animals.

9 Aug 2021

New insights on an enzyme complex involved in plaque production

A research team led by Wim Annaert (VIB-KU Leuven) uncovered the early assembly of gamma-secretase, a protein complex linked to numerous cellular processes including the development of Alzheimer's disease.

23 Jul 2021

Children with rare genetic disorder experience dramatic improvements in a gene therapy trial

Children with a devastating genetic disorder characterized by severe motor disability and developmental delay have experienced sometimes dramatic improvements in a gene therapy trial launched at UCSF Benioff Children's Hospitals.

13 Jul 2021

Misfolded tau proteins cause progressive degeneration in Alzheimer's disease

According to a study performed by researchers from the Van Andel Institute and the University of Pennsylvania, misfolded proteins that impair neurons in Alzheimer’s disease travel the “roads” of the brain, similar to a supply truck crossing the countryside.

11 Jun 2021

Brain study provides new insights on dementia

The largest study to date has provided a better understanding of how genes are controlled in dementia, including the identification of 84 novel genes associated with the condition.

11 Jun 2021

Study reveals the first look of brains retrieving faulty memories

Scientists have observed for the first time what it looks like in the key memory region of the brain when a mistake is made during a memory trial.

9 Jun 2021

Developing computational tools to illuminate how genetic factors impact the brain

Liang Zhan, assistant professor of electrical and computer engineering at Pitt's Swanson School of Engineering, received a $500,000 CAREER award from the National Science Foundation to develop computational tools that improve our understanding of the human brain.

8 Jun 2021

Single biomarker in the blood can accurately indicate underlying neurodegeneration

Levels of a protein called neurofilament light chain (NfL) in the blood can identify those who might have neurodegenerative diseases such as Down's syndrome dementia, motor neuron disease (ALS) and frontotemporal dementia, when clinical symptoms are not definitive.

8 Jun 2021

New study on genotype-phenotype associations sheds light on human complex traits, diseases

A new study analyzing the association between an individual's genetics (genotype) and their observable characteristics resulting from the interaction of genetics and the environment (phenotype), contributes new knowledge to the understanding of human complex traits and diseases.

2 Jun 2021

Study shows why “the brain's memory center” is vulnerable to damage, degeneration

In a world first, scientists from the University of Sussex have recorded blood oxygen levels in the hippocampus and provided experimental proof for why the area, commonly referred to as 'the brain's memory center', is vulnerable to damage and degeneration, a precursor to Alzheimer's disease.

31 May 2021

Researchers suggest new strategies for finding drugs that neutralize key enzymes

Scientists from the UK's University of Bath explore racemases - an important type of enzyme that is linked to certain cancers and other life-threatening diseases while also being critical to cell function - in a paper published in the prestigious journal Chemical Society Reviews. The scientists also propose new strategies for finding drugs that neutralize these enzymes.

26 May 2021

Researchers devise a small-molecule cocktail to protect stem cells from stress

Researchers at the National Institutes of Health (NIH) have devised a four-part small-molecule cocktail that can protect stem cells called induced pluripotent stem cells (iPSCs) from stress and maintain normal stem cell structure and function.

4 May 2021

Chaperone protein imbalance initiates toxic accumulation of tau in the aging brain

Chaperone protein imbalance can play a significant role in initiating toxic accumulation of tau in the aging brain - an early step in the development of Alzheimer's disease and related neurodegenerative disorders known as tauopathies, a new preclinical study by University of South Florida Health (USF Health) neuroscientists suggests.

21 Apr 2021

Researchers identify overlapping genetic locations that shape face and the brain

An interdisciplinary team led by KU Leuven and Stanford has identified 76 overlapping genetic locations that shape both our face and our brain.

6 Apr 2021

Alzheimer's Disease News and Research

Further Reading

Study uses mouse models to identify the likely cause of Alzheimer's disease

Researchers develop novel cell reprogramming strategy to slow down glioblastomas

Scientists use stem cells to investigate the genetic risk for Alzheimer's disease

NYU Tandon professors show broad therapeutic potential of novel peptide to combat multiple diseases

New mouse line reveals the state of proteostasis in mammalian brain for the first time

Study reveals how 3D space is represented in the mammalian cortex by the brain's 'GPS'

Muscle protein tied to physical fitness in youth and age-associated diseases

New insights on an enzyme complex involved in plaque production

Children with rare genetic disorder experience dramatic improvements in a gene therapy trial

Misfolded tau proteins cause progressive degeneration in Alzheimer's disease

Brain study provides new insights on dementia

Study reveals the first look of brains retrieving faulty memories

Developing computational tools to illuminate how genetic factors impact the brain

Single biomarker in the blood can accurately indicate underlying neurodegeneration

New study on genotype-phenotype associations sheds light on human complex traits, diseases

Study shows why “the brain's memory center” is vulnerable to damage, degeneration

Researchers suggest new strategies for finding drugs that neutralize key enzymes

Researchers devise a small-molecule cocktail to protect stem cells from stress

Chaperone protein imbalance initiates toxic accumulation of tau in the aging brain

Researchers identify overlapping genetic locations that shape face and the brain

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