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Genetic and molecular mechanisms make chemotherapy drug work for some cancer patients

The chemotherapy drug decitabine is commonly used to treat patients with blood cancers, but its response rate is somewhat low. Researchers have now identified why this is the case, opening the door to more personalized cancer therapies for those with these types of cancers, and perhaps further afield.

25 May 2021

“Paralyzed” immune cells can be reactivated by drugs in IDH-mutant gliomas

Brain tumor cells with a certain common mutation reprogram invading immune cells. This leads to the paralysis of the body's immune defense against the tumor in the brain. Researchers from Heidelberg, Mannheim, and Freiburg discovered this mechanism and at the same time identified a way of reactivating the paralyzed immune system to fight the tumor.

25 May 2021

Telomere length decreases most rapidly from birth to age 3, shows study

Telomeres are protective caps on DNA that shorten as we grow older. Now, one of the first studies to examine telomere length (TL) in childhood finds that the initial setting of TL during prenatal development and in the first years of life may determine one's TL throughout childhood and potentially even into adulthood or older age.

25 May 2021

Exposure to chemicals in plastic during the fetal stage is linked with a lower IQ

Bisphenol F chemical (found in plastics) may cause changes in a gene that is crucial for neurological development. Researchers from the Swedish universities of Uppsala and Karlstad made this discovery.

21 May 2021

Study identifies predictive causal role for specific cell types in type 1 diabetes

Researchers revealed a predicted causative role for certain cell types in type 1 diabetes by examining its genetic foundations.

From UC San Diego 20 May 2021

Exposure to even low levels of lead can trigger epigenetic changes

A research team from Brazil and Portugal has identified a link between a microRNA (miRNA) and the presence of lead in an organism.

18 May 2021

New kind of biomolecule could play a vital role in the biology of all living things

Stanford researchers have discovered a new kind of biomolecule that could play a significant role in the biology of all living things.

18 May 2021

Cells within the center of a tumor have the highest chance of spreading around the body

Researchers from the Francis Crick Institute, Royal Marsden, UCL and Cruces University Hospital have found that cells from different parts of kidney tumors behave differently, and surprisingly, cells within the center of a tumor are the most aggressive and have the highest chance of spreading around the body.

18 May 2021

Combination of Omega-3S in supplements may blunt the cardiovascular benefits of EPA

Doctors often recommend Omega-3s to help patients lower their cholesterol and improve heart health. Those Omega-3s can come from fatty fish like salmon and mackerel, or supplements that often contain a combination of the acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA).

17 May 2021

Epigenetic changes drive the fate of a B cell

B cells are the immune cells responsible for creating antibodies, and most B cells produce antibodies in response to a pathogen or a vaccine, providing immunity.

14 May 2021

New drug-like compound designed to stop malaria in its tracks

Researchers at the Francis Crick Institute and the Latvian Institute of Organic Synthesis have designed a drug-like compound which effectively blocks a critical step in the malaria parasite life cycle and are working to develop this compound into a potential first of its kind malaria treatment.

13 May 2021

Novel peptide could allow cannabis to relieve pain while avoiding side effects

Many people live with chronic pain, and in some cases, cannabis can provide relief. But the drug also can significantly impact memory and other cognitive functions.

13 May 2021

Scientists discover genes responsible for smoking-related decline in lung function

(Boston)--Chronic Obstructive Pulmonary Disease (COPD) is a disease caused by cigarette smoking that reduces lung function and causes difficulty breathing.

12 May 2021

New method can enable early detection and treatment of cerebral aneurysms

Cerebral aneurysms are malformations caused by abnormalities on the walls of blood vessels in the brain. When these blood vessels rupture, about 30% of the sufferers die on the spot, giving these the rightful label of 'ticking bombs in the head'.

11 May 2021

Mutations in GEMIN5 protein can cause rare genetic disorders in children

Researchers have discovered a genetic cause of an unusual neurological disorder characterized by developmental delay, known as ataxia.

From University of Pittsburgh 10 May 2021

Inclusion of soybean and linseed oils in the diet of dairy cows improves milk quality

Inclusion of soybean and linseed oils in the diet of dairy cows made the fatty acid content of their milk even healthier for human nutrition. It also increased the proportions of omega-6 and omega-3, which in the right balance play a key role in preventing cardiovascular diseases, for example, as well as chronic inflammation and some kinds of cancer.

10 May 2021

Highly efficient method to identify the genetic “switches” that control gene expression

Scientists have created a high-throughput method to help explain and regulate gene expression for the treatment of diseases like beta-thalassemia and sickle cell disease.

7 May 2021

Study unravels a crucial element that influences gene expression in blood stem cells

A complex network of biochemical pathways keeps the living organism healthy and alive.

From National University of Singapore (NUS) 7 May 2021

Researchers sequence genome of raccoon dogs that are reservoir hosts for coronaviruses

For the first time, a research team has sequenced the genome of a raccoon dog. Genetic data now supports the animal’s ability to spread SARS-CoV-2.

6 May 2021

New technology efficiently detects gene mutation in blood with low error rate

Next-generation gene sequencing (NGS) technologies --in which millions of DNA molecules are simultaneously but individually analyzed-- theoretically provides researchers and clinicians the ability to noninvasively identify mutations in the blood stream.

5 May 2021

Blood News and Research

Genetic and molecular mechanisms make chemotherapy drug work for some cancer patients

“Paralyzed” immune cells can be reactivated by drugs in IDH-mutant gliomas

Telomere length decreases most rapidly from birth to age 3, shows study

Exposure to chemicals in plastic during the fetal stage is linked with a lower IQ

Study identifies predictive causal role for specific cell types in type 1 diabetes

Exposure to even low levels of lead can trigger epigenetic changes

New kind of biomolecule could play a vital role in the biology of all living things

Cells within the center of a tumor have the highest chance of spreading around the body

Combination of Omega-3S in supplements may blunt the cardiovascular benefits of EPA

Epigenetic changes drive the fate of a B cell

New drug-like compound designed to stop malaria in its tracks

Novel peptide could allow cannabis to relieve pain while avoiding side effects

Scientists discover genes responsible for smoking-related decline in lung function

New method can enable early detection and treatment of cerebral aneurysms

Mutations in GEMIN5 protein can cause rare genetic disorders in children

Inclusion of soybean and linseed oils in the diet of dairy cows improves milk quality

Highly efficient method to identify the genetic “switches” that control gene expression

Study unravels a crucial element that influences gene expression in blood stem cells

Researchers sequence genome of raccoon dogs that are reservoir hosts for coronaviruses

New technology efficiently detects gene mutation in blood with low error rate

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