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New Insights into Nager Syndrome Through Zebrafish Models

Nager syndrome, or NS, is a rare genetic disease that affects the development of the face and limbs, usually causing anomalies in the bone structures of the jaws, cheeks, and hands.

17 Oct 2024

Proteomics Analysis Reveals Aging-Related Changes in Bone

Bone mass declines with age, and the anabolic response to mechanical loading weakens. Although much research has focused on gene transcription, the mechanisms behind bone aging and the loss of mechanoresponsiveness at the protein level are still not well understood.

16 Oct 2024

Proteomics Reveals Age-Related Changes in Mouse Bone Formation

A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science), Volume 16, Issue 19 on October 12, 2024, entitled, "A proteomics approach to study mouse long bones: examining baseline differences and mechanical loading-induced bone formation in young-adult and old mice."

16 Oct 2024

Next-Generation Sequencer Enhances Genetic Research at UT Arlington

The North Texas Genome Center (NTGC) at UT Arlington is getting an upgrade in the form of a next-generation genetic sequencer that will allow researchers to study genetic links between health and disease at a large scale.

16 Oct 2024

Disrupting a Gene Boosts T Cell Therapy, St. Jude Study Shows

Immunotherapy, using a patient's own immune system to treat disease, has shown promise in some patients with cancer but has not worked in most.

15 Oct 2024

Blood Vessel Cells Play a Crucial Role in Bone Development

Researchers have discovered a protein that inhibits the activity of bone-forming cells (osteoblasts) by preventing their maturation during the process of migrating to bone-formation sites.

14 Oct 2024

New Research Examines the Role of Skeletal Stem Cells in Bone Growth and Regeneration

Researchers at UTHealth Houston have been awarded an $8.1 million grant by the National Institutes of Health (NIH) to examine skeletal stem cells as potential drivers of craniofacial bone diseases and deformities. The study is led by Noriaki Ono, DDS, PhD, associate professor of orthodontics, and diagnostic and biomedical sciences at UTHealth Houston School of Dentistry.

14 Oct 2024

New Approach Aims to Enhance CRISPR Safety and Precision

CRISPR is a revolutionary tool that allows scientists to precisely modify the genome and gene expression of cells in any organism.

8 Oct 2024

The Role of Macrophages in Shaping the Inflammatory Environment in Rheumatoid Arthritis

Currently there are no cures for rheumatoid arthritis (RA) which affects 40,000 people in Ireland. The disease costs an estimated €20,000 per patient, per year with an overall cost to the health system of ~€544 million. Only 1 in 4 patients achieve remission and a significant proportion of patients have suboptimal responses or no response at all to current available therapies.

30 Sep 2024

New Method Analyzes Tooth Enamel Proteins to Gain Insights into Human Health History

A new way of looking at tooth enamel could give scientists a path to deeper understanding of the health of human populations, from the ancient to the modern.

20 Sep 2024

Innovative Approach Supercharges T Cells by Transferring Healthy Mitochondria

Fighting cancer is exhausting for T cells. Hostile tumor microenvironments can drain their mitochondrial activity, leading to a condition known as T cell exhaustion.

16 Sep 2024

Research Shows Evolutionary Divergence in Knee Bones of Primates

The evolution of bones in primates' knees could have implications for how humans evolved to walk upright, a new study has found.

11 Sep 2024

From Bone Regeneration to Heart Repair: Stem Cell Transplantation Paves the Way for New Medical Frontiers

Stem cell transplantation offers promising solutions for tissue regeneration and age-related degeneration, despite challenges in safety and production costs.

9 Sep 2024

Inflammation-Induced Epigenetic Changes Limit Intestinal Stem Cell Regeneration

Researchers from the University of Michigan, Baylor College of Medicine, and other affiliated institutions have found that intestinal stem cells (ISCs) are permanently altered by inflammation in the gut, which limits the cells' capacity to repair the gut even after the inflammation has subsided.

4 Sep 2024

Melbourne Researchers Achieve Breakthrough in Creating Human-Like Blood Stem Cells

Melbourne researchers have made a world first breakthrough into creating blood stem cells that closely resemble those in the human body.

3 Sep 2024

Mechanical Manipulation of Stem Cells Promises New Treatments

New stem cell therapies may result from a novel method that McGill researchers have created for mechanically modifying stem cells, which has not yet reached its full therapeutic potential.

14 Aug 2024

Research Unlocks Secrets of Stem Cell Retention in Bone Marrow

A discovery by a three-member Albert Einstein College of Medicine research team may boost the effectiveness of stem-cell transplants, commonly used for patients with cancer, blood disorders, or autoimmune diseases caused by defective stem cells, which produce all the body's different blood cells. The findings, made in mice, were published today in the journal Science.

9 Aug 2024