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COVID-19 vaccines prompt the body to make long-lasting T cells against different variants

Scientists at La Jolla Institute for Immunology (LJI) have found that four COVID-19 vaccines (Pfizer-BioNTech, Moderna, J&J/Janssen, and Novavax) prompt the body to make effective, long-lasting T cells against SARS-CoV-2.

25 Jan 2022

Study helps identify how immune system cells identify and eradicate tumors

In the last 10 years, immunotherapy has been used to save the lives of several cancer patients with lung cancer.

13 Dec 2021

Covid-19 vaccine-elicited immune cells persist six months after vaccination, study shows

A recent study by Johns Hopkins Medicine researchers provides evidence that CD4+ T lymphocytes — immune system cells also known as helper T cells — produced by people who received either of the two available messenger RNA (mRNA) vaccines for COVID-19 persist six months after vaccination at only slightly reduced levels from two weeks after vaccination and are at significantly higher levels than for those who are unvaccinated.

17 Nov 2021

CRISPR screening identifies metabolic enzyme as new target for anti-inflammatory therapeutics

A metabolic enzyme that has been studied in cancer biology and is important for T cell function may offer a new target for anti-inflammatory therapeutics, Vanderbilt researchers have discovered.

12 Nov 2021

INTEGRA’s VOYAGER helps HIV researchers get more results in significantly less time

INTEGRA’s VOYAGER adjustable tip spacing pipette is supporting crucial experimental work in longitudinal HIV studies.

From INTEGRA Biosciences 12 Nov 2021

Metabolic restoration could provide natural protection against HIV

The human immunodeficiency virus (HIV-1) particularly attacks CD4 lymphocytes, a type of white blood cell considered to be the conductor of the immune system.

19 Oct 2021

New study reveals lung cell roles in guiding the immune system

Lung immunity is essential to combat all pulmonary diseases, including COVID-19, pneumonia, lung cancer, asthma and COPD.

6 Oct 2021

Researchers discover underlying metabolic changes that may be pivotal in severe COVID-19

COVID-19 patients have differing immune responses that lead to disease outcomes ranging from asymptomatic SARS-CoV-2 infection to death.

7 Sep 2021

T cell-depleted macaques can mount potent memory responses against SARS-CoV-2

New research conducted in monkeys reveals that T cells are not critical for the recovery of primates from acute COVID-19 infections.

28 Jul 2021

New tool sheds light on enzymatic activity linked to blood cancers, heart disease

Scientists have provided a better understanding of a process in immune cells that could help explain why certain people develop cardiovascular disease.

28 Jun 2021

Warped immune cell signaling during bile acid exposure may lead to Crohn’s disease

People with Crohn's disease are typically treated with powerful anti-inflammatory medications that act throughout their body, not just in their digestive tract, creating the potential for unintended, and often serious, side effects.

8 Apr 2021

Study shows how a subset of T cells is generated in melanoma survivors affected by vitiligo

A few patients suffering from melanoma are known to respond quite well to immunotherapy and experience significant and long-lasting tumor regression.

25 Mar 2021

Protein kinases may offer a solution to treat HIV patients with immunodeficiency

A new study indicates that protein kinases, which initiate the process that erodes the body’s immunity, significantly contribute to the immunodeficiency in HIV patients. Drugs that block these protein kinases may offer a solution to treating HIV patients whose immunity is not restored by antiretroviral therapy.

2 Mar 2021

Animal model yields important insights into T cell exhaustion

T lymphocytes, or T cells, are an important component of our immune system. They can recognize foreign proteins, so-called antigens, as peptide fragments - for instance, those derived from viruses or cancer cells.

15 Feb 2021

New therapeutic approach to restore the effectiveness of immune cells

Prompted by the need to improve conventional treatments for people infected with the human immunodeficiency virus (HIV-1), a team from the Institut national de la recherche scientifique (INRS) has identified a therapeutic approach to restore the effectiveness of immune cells.

10 Feb 2021

CD4 News and Research

COVID-19 vaccines prompt the body to make long-lasting T cells against different variants

Study helps identify how immune system cells identify and eradicate tumors

Covid-19 vaccine-elicited immune cells persist six months after vaccination, study shows

CRISPR screening identifies metabolic enzyme as new target for anti-inflammatory therapeutics

INTEGRA’s VOYAGER helps HIV researchers get more results in significantly less time

Metabolic restoration could provide natural protection against HIV

New study reveals lung cell roles in guiding the immune system

Researchers discover underlying metabolic changes that may be pivotal in severe COVID-19

T cell-depleted macaques can mount potent memory responses against SARS-CoV-2

New tool sheds light on enzymatic activity linked to blood cancers, heart disease

Warped immune cell signaling during bile acid exposure may lead to Crohn’s disease

Study shows how a subset of T cells is generated in melanoma survivors affected by vitiligo

Protein kinases may offer a solution to treat HIV patients with immunodeficiency

Animal model yields important insights into T cell exhaustion

New therapeutic approach to restore the effectiveness of immune cells

Study shows major differences in mild versus severe COVID-19 infection

Researchers demonstrate potential preventive treatment for Crohn's disease

Researchers detect new immune cells that act as major driver of breast cancer growth

Study: DOT1L enzyme is essential for humoral immune responses

Scientists successfully edit SIV virus from genomes of non-human primates

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