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Latest CRISPR-Cas Gene Editing Can Eliminate All Traces of HIV Virus From Infected Cells

New research presented early ahead of this year's European Congress of Clinical Microbiology and Infectious Diseases (ECCMID 2024, Barcelona, 27-30 April) from a team of researchers in the Netherlands shows how the latest CRISPR-Cas gene editing technology can be used to eliminate all traces of the HIV virus from infected cells in the laboratory, raising hopes of a cure.

20 Mar 2024

Drug Candidates Show Promise to Reverse HIV's Ability to Escape Immune System Detection

University of Pittsburgh School of Medicine scientists have identified drug candidates that show promise to reverse the ability of HIV to escape detection by the immune system.

20 Mar 2024

Unveiling HIV's Hidden Entry Point for Targeted Antibodies

As the HIV virus approaches a human cell to dock and potentially deliver its lethal genetic code, there is a remarkably brief moment during which a tiny portion of its surface undergoes a rapid opening, initiating the infection process.

5 Feb 2024

Boosting Central Memory T Cells with Targeted Protein Modulation

The Hackensack Meridian Center for Discovery and Innovation's (CDI) Xue Lab has made yet another advancement in the understanding of the immune system and its potential for disease-fighting modulation.

22 Jan 2024

CD4+ T Cells Revealed as Powerful Cancer Killers

Researchers have unveiled groundbreaking insights into CD4+ T cells, a kind of immune cell, demonstrating the potential for immunotherapies targeting melanoma, the most fatal kind of skin cancer.

22 Jan 2024

LJI Researchers Identify Late-Rising T Cells Crucial for CMV Control

Cytomegalovirus (CMV) is a pathogen that likes to lurk. Most adults already carry CMV, and they show no symptoms at all.

22 Jan 2024

Biotium Launches New Line of Extensively Validated Primary Antibody Conjugates for Flow Cytometry

Biotium, a leading provider of innovative solutions for life science research, is thrilled to announce the launch of Biotium Choice primary antibody conjugates. With careful curation, and extensive in-house validation, Biotium Choice monoclonal primary antibodies are designed to deliver exceptional performance for flow cytometry.

From Biotium, Inc. 6 Dec 2023

Revolutionizing Fish Immunology: A Paradigm Shift in Antibody Responses

Upon infection or immunization, antibodies, produced by all jawed vertebrates, serve to bind and neutralize pathogens.

4 Dec 2023

LJI Scientists Harness 'Helper' T Cells To Treat Tumors

Scientists are on the hunt for a unique set of mutations, called "neoantigens," that let the immune system distinguish tumor cells from normal cells. Their goal is to help the immune system react to neoantigens and target tumor cells for destruction.

4 Sep 2023

T Cells Play a Dual Role in Wasting During Infection

Even though infections can be presented with several different symptoms, one common symptom is known to be the loss of fat and muscle, a process known as wasting.

25 Jul 2023

Cellular Interactions and the Extension of Liver Transplant Recipients’ Lives

A recent study explains how the immune system’s interaction with certain proteins causes organ rejection.

20 Jul 2023

T-Cell Analysis for Type 1 Diabetes Preventive Therapy

Scripps Researchers have found that looking at a certain type of immune cell in the blood can help pinpoint those who are most vulnerable to acquiring type 1 diabetes, a fatal autoimmune disease

20 Jul 2023

New Insights into the Regulatory Network of Th17 Cells

N6-methyladenosine (m6A) is the most extensively studied RNA modification across multiple species, and its importance in the immune system has been demonstrated in a variety of contexts, including mRNA metabolism, cell differentiation, proliferation, and response to stimulation.

17 Jul 2023

T cells are Sensitive to Genetic Disturbances Within Mitochondrial Power Plants

All cells have their own power plants, called mitochondria. There are often more than 100 mitochondria per cell and each possesses their own genome, which in turn contains genes responsible for energy production.

7 Jul 2023

Microglial Cells Serve as a Stable Viral Reservoir for Latent HIV

Human immunodeficiency virus-1 (HIV) introduces a copy of its DNA into human immune cells as part of its life cycle. Some of these newly infected immune cells can subsequently enter an inactive, latent state for an extended length of time, which is known as HIV latency.

19 Jun 2023

Understanding How Genes Predispose Humans to Allergies

New research is expanding the scientific understanding of why some people are more allergic than others. Researchers at the University of Pennsylvania’s Perelman School of Medicine discovered how genetic changes that modify a specific protein called ETS1 can affect our body’s response to allergens.

16 Jun 2023