Cancer News and Research

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Cancer begins in your cells, which are the building blocks of your body. Normally, your body forms new cells as you need them, replacing old cells that die. Sometimes this process goes wrong. New cells grow even when you don't need them, and old cells don't die when they should. These extra cells can form a mass called a tumor. Tumors can be benign or malignant. Benign tumors aren't cancer while malignant ones are. Cells from malignant tumors can invade nearby tissues. They can also break away and spread to other parts of the body.

Study identifies a pair of microRNA molecules that maintain the population of cancerous stem cells

A research team from Italy has discovered a pair of microRNA molecules that assist in maintaining a population of cancerous stem cells that fuel the growth of breast cancers and trigger tumor relapse after treatment.

5 Apr 2021

Low K777 concentrations inhibit cathepsin L and reduce SARS-CoV-2’s ability to infect host cell lines

For a long time, James McKerrow, MD, PhD, dean of the Skaggs School of Pharmacy and Pharmaceutical Sciences at University of California San Diego, has investigated neglected tropical diseases, which are chronic, disabling parasitic infections mainly affecting the poor and underserved communities in developing nations.

From UC San Diego 5 Apr 2021

New mechanism of transcriptional regulators influences tumor development

The Wistar Institute scientists have discovered a novel mechanism of transcriptional regulation of cellular senescence that promotes the release of inflammatory molecules that, in turn, affect tumor growth by changing the surrounding microenvironment.

2 Apr 2021

New AI-based method can lead to faster, low-cost development of protein-based drugs

Thanks to a newly published study by scientists, artificial intelligence (AI) can now create novel and functionally active proteins.

1 Apr 2021

AI-based software for automatic tracking of cells in microscope videos

In modern basic life science research as well as in drug discovery, recording and analyzing the images of cells over time using 3D microscopy has become extremely important.

31 Mar 2021

Developing a new CRISPR technique

Researchers from Vanderbilt University spoke to AZoLifeSciences about a new CRISPR technique that could help us to further understand the mechanisms behind cancer.

From Vanderbilt University 31 Mar 2021

Strong cell-cell junctions preserve the quiescent properties of stem cells

The skin is known to be the largest organ in the human body, and its outermost layer, called the epidermis, is renewed every three weeks.

29 Mar 2021

Study reveals molecular mechanisms involved in the maintenance of naïve embryonic stem cells

Researchers have explained mechanisms that play a role in maintaining the embryonic stem cells in the most optimized state for use in regenerative medicine.

26 Mar 2021

New label-free immune profiling assay to assess rapidly changing host immune response

Researchers from Critical Analytics for Manufacturing Personalized-Medicine (CAMP), an Interdisciplinary Research Group (IRG) at the Singapore-MIT Alliance for Research and Technology (SMART), MIT's research enterprise in Singapore, have developed a new label-free immune profiling assay that profiles the rapidly changing host immune response in case of infection, in a departure from existing methods that focus on detecting the pathogens themselves, which can often be at low levels within a host.

26 Mar 2021

Depletion of stem cells could be a significant factor behind miscarriage

Depletion of a certain type of stem cell in the womb lining during pregnancy could be a significant factor behind miscarriage, according to a study released today in STEM CELLS. The study, by researchers at Warwick Medical School, University of Warwick, Coventry, England, reports on how recurrent pregnancy loss is a result of the loss of decidual precursor cells prior to conception.

26 Mar 2021

Researchers use mathematical modeling to explain CAR T-cell therapy dynamics

Chimeric antigen receptor T-cell therapy, or CAR T, is a relatively new type of therapy approved to treat several types of aggressive B cell leukemias and lymphomas.

26 Mar 2021

Scientists identify new biomarkers in the blood of patients with malignant melanoma

A team of researchers has studied the molecular profile of small “messenger” vesicles called exosomes, produced by cancer stem cells (CSCs), which play a key role in the process of carcinogenesis and metastasis in the blood of patients with malignant melanoma.

26 Mar 2021

Study shows how a subset of T cells is generated in melanoma survivors affected by vitiligo

A few patients suffering from melanoma are known to respond quite well to immunotherapy and experience significant and long-lasting tumor regression.

25 Mar 2021

Novel vaccine uses patient's own tumor cells to train the immune system to fight cancer

Immunotherapy, which recruits the body's own immune system to attack cancer, has given many cancer patients a new avenue to treat the disease.

25 Mar 2021

Genetically engineered immune cells deliver anticancer signal to organs to prevent metastasis

Scientists have genetically engineered immune cells, called myeloid cells, to precisely deliver an anticancer signal to organs where cancer may spread.

From National Cancer Institute (NCI) 25 Mar 2021

Specific enzyme can delay the growth and spread of neck and head carcinomas

Scientists were able to considerably delay the growth and proliferation of tumors in mice and improve the effectiveness of immunotherapy.

24 Mar 2021

Study into cellular filopodia could optimize cancer therapy and wound closure

Imagine using only a finger to heal a wound! It seems like science fiction, reminding one of the 1982 movie E.T.

23 Mar 2021

Bacteria residing within tumor cells may boost cancer immunotherapy

Cancer immunotherapy may get a boost from an unexpected direction: bacteria residing within tumor cells. In a new study published in Nature, researchers at the Weizmann Institute of Science and their collaborators have discovered that the immune system "sees" these bacteria and shown they can be harnessed to provoke an immune reaction against the tumor.

23 Mar 2021

Hormone drugs may help disarm coronavirus spike protein and stop disease progression

Hormone drugs that reduce androgen levels may help disarm the coronavirus spike protein used to infect cells and stop the progression of severe COVID-19 disease, suggests a new preclinical study from researchers in the Abramson Cancer Center at the University of Pennsylvania and published online in Cell Press's iScience.

23 Mar 2021

Study reveals mechanism by which ibuprofen prevents RAC1B alternative splicing in colorectal cells

Oncotarget published "Ibuprofen disrupts a WNK1/GSK3β/SRPK1 protein complex required for expression of tumor-related splicing variant RAC1B in colorectal cells" which reported that although the molecular mechanism behind the antitumor properties of NSAIDs has been largely attributed to inhibition of cyclooxygenases , several studies have shown that the chemopreventive properties of ibuprofen also involve multiple COX-independent effects.

23 Mar 2021

Cancer News and Research

Study identifies a pair of microRNA molecules that maintain the population of cancerous stem cells

Low K777 concentrations inhibit cathepsin L and reduce SARS-CoV-2’s ability to infect host cell lines

New mechanism of transcriptional regulators influences tumor development

New AI-based method can lead to faster, low-cost development of protein-based drugs

AI-based software for automatic tracking of cells in microscope videos

Developing a new CRISPR technique

Strong cell-cell junctions preserve the quiescent properties of stem cells

Study reveals molecular mechanisms involved in the maintenance of naïve embryonic stem cells

New label-free immune profiling assay to assess rapidly changing host immune response

Depletion of stem cells could be a significant factor behind miscarriage

Researchers use mathematical modeling to explain CAR T-cell therapy dynamics

Scientists identify new biomarkers in the blood of patients with malignant melanoma

Study shows how a subset of T cells is generated in melanoma survivors affected by vitiligo

Novel vaccine uses patient's own tumor cells to train the immune system to fight cancer

Genetically engineered immune cells deliver anticancer signal to organs to prevent metastasis

Specific enzyme can delay the growth and spread of neck and head carcinomas

Study into cellular filopodia could optimize cancer therapy and wound closure

Bacteria residing within tumor cells may boost cancer immunotherapy

Hormone drugs may help disarm coronavirus spike protein and stop disease progression

Study reveals mechanism by which ibuprofen prevents RAC1B alternative splicing in colorectal cells

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