Carcinoma is cancer that begins in the skin or in tissues that line or cover internal organs.
A targeted drug has shown promising activity against brain metastases resulting from kidney cancer, achieving a 50 percent response rate, and supporting further studies of the drug in this patient group whose poor prognosis has created a significant unmet need.
Multi-institutional researchers have succeeded in efficiently delivering an immune checkpoint inhibitor (ICI) into the mouse brain, confirming its high efficacy and specificity in treating orthotopically transplanted mice with glioblastoma (GBM). The research was published in Nature Biomedical Engineering.
Malignant tumors can enhance their ability to survive and spread by suppressing antitumor immune cells in their vicinity, but a study led by researchers at Weill Cornell Medicine and NewYork-Presbyterian has uncovered a new way to counter this immunosuppressive effect.
A group of scientists from the University of Texas at Austin created a novel approach to tag tumor cells to identify how they evolve and change eventually to resist cancer treatments.
Lung cancer remains the leading cause of cancer-associated death in the United States and worldwide. Patients with a subtype called lung adenocarcinoma (LUAD) have benefited from the development of new targeted medicines, but the search for effective new therapies for another subtype called lung squamous cell carcinoma (LSCC) has largely come up short.
Struggling against a tumor is not a sprint. It is a marathon. The race of cancer-fighting T cells is at times simply very long, and the T cells give up fighting. This phenomenon is referred to as T cell exhaustion by researchers.
Researchers published an article that represents the transmission electron microscopy (TEM) and flow cytometry study of A-549 (human lung carcinoma) cellular uptake of Pr3+:LaF3 nanoparticles.
Dr Manual Kaulich’s team at Goethe University has developed a new 3Cs multiplex approach that permits the effect of genetic alterations in any two genes to be investigated simultaneously in cell cultures.
In a recent study, researchers investigated how natural killer cells target breast cancer using the body's own immune system.
Just a small number of cells found in tumors can enable and recruit other types of cells nearby, allowing the cancer to spread to other parts of the body, report Georgetown Lombardi Comprehensive Cancer Center scientists.
Treatment with an immunotherapy drug following kidney cancer surgery, prolonged disease-free survival rates in patients at high risk for recurrence, according to an interim report of a phase 3 clinical trial of adjuvant immunotherapy in this patient population.
Oncotarget published "Global DNA hypermethylation pattern and unique gene expression signature in liver cancer from patients with Indigenous American ancestry" which reported that contrasting with this pattern, the age structure of HCC in Andean people displays a bimodal distribution with half of the patients developing HCC in adolescence and early adulthood.
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide. NAFLD patients are at higher risk of developing Non-alcoholic steatohepatitis (NASH), which causes severe and chronic liver inflammation, fibrosis and liver damage.
Up to half of patients with head and neck squamous cell carcinoma will experience tumor recurrence or new tumors--tumors that often spread and are difficult to treat.
Scientists were able to considerably delay the growth and proliferation of tumors in mice and improve the effectiveness of immunotherapy.
Researchers at the Francis Crick Institute, the UCL Cancer Institute, and the Cancer Research UK Lung Cancer Centre of Excellence have identified genetic changes in tumours which could be used to predict if immunotherapy drugs would be effective in individual patients.
Cells need energy to survive and thrive. Generally, if oxygen is available, cells will oxidize glucose to carbon dioxide, which is very efficient, much like burning gasoline in your car. However, even in the presence of adequate oxygen, many malignant cells choose instead to ferment glucose to lactic acid, which is a much less efficient process.
Proteogenomic studies may provide a better understanding of how to match cancer patients with an effective treatment for their specific cancer.
Scientists have successfully utilized a novel stem cell technology to examine the skin, specific to a group of living patients, in laboratory settings.
A recent study by researchers at the University of Jyväskylä was successful in partially preventing fatty liver disease in rats.