Cartilage is a stiff yet flexible connective tissue found in many areas in the bodies of humans and other animals, including the joints between bones, the rib cage, the ear, the nose, the elbow, the knee, the ankle, the bronchial tubes and the intervertebral discs.
The IL-6 protein family has a poor reputation for promoting inflammation, arthritis, autoimmune disease, and even cancer.
Researchers from Tokyo Metropolitan University have discovered how the sponginess and stickiness of stem cell nuclei controls how they "differentiate" into specialized cells. They found that the nucleus starts solid-like but becomes more fluid-like over time.
Researchers at the University of Bonn have developed a method to generate embryo-like cell complexes from the stem cells of mice. The method provides new insights into embryonic development. In the medium term, it might also be suitable for developing tests for substances that could be harmful to fertility. The study is published in the prestigious journal Nature Communications.
The existing methods for the regeneration of injured cartilage generate tissue that breaks down. This deterioration eventually leads to osteoarthritis—the commonly seen form of arthritis—affecting over 32.5 million grown-ups in the United States, as per the Centers for Disease Control and Prevention.
According to recent research, a sugar-containing polymer coating can one day help repair artificial joint implants, such as hip replacements.
According to research by the University of the West of Scotland, antiviral drugs can be produced from earlier overlooked substances seen in marine plants.
The major cause of pain and disability globally is osteoarthritis.
Mesenchymal stem cells (MSCs) are anticipated to harbor great potential in the area of regenerative medicine, which aims at restoring damaged tissues.
A group of researchers headed by Professor Dr Bent Brachvogel, Head of Experimental Neonatology at the Faculty of Medicine and University Hospital Cologne, have identified regulatory mechanisms of tissue organization which were earlier unknown.
Scientists from the University of Southampton have identified a novel means to create human cartilage tissue from stem cells.
A team of scientists from the Institute of Vertebrate Paleontology and Paleoanthropology (IVPP) of the Chinese Academy of Sciences and from the Shandong Tianyu Museum of Nature (STM) has isolated exquisitely preserved cartilage cells in a 125-million-year-old dinosaur from Northeast China that contain nuclei with remnants of organic molecules and chromatin.
The bones become thinner with age, resulting in frequent fractures and making them susceptible to bone diseases like osteoporosis.
With a goal of developing rheumatoid arthritis therapies with minimal side effects, researchers at Washington University School of Medicine in St. Louis have genetically engineered cells that, when implanted in mice, will deliver a biologic drug in response to inflammation.
Wake Forest researchers and clinicians are using patient-specific tumor 'organoid' models as a preclinical companion platform to better evaluate immunotherapy treatment for appendiceal cancer, one of the rarest cancers affecting only 1 in 100,000 people.
A 3D biomaterial scaffold design to slowly release stem cells has worked to ensure implanted stem cells stick around to relieve pain and reverse arthritis in mice knee joints.
A new automated process prints a peptide-based hydrogel scaffold containing uniformly distributed cells. The scaffolds hold their shapes well and successfully facilitate cell growth that lasts for weeks.
Imagine if surgeons could transplant healthy neurons into patients living with neurodegenerative diseases or brain and spinal cord injuries.
A new type of stem cell - that is, a cell with regenerative abilities - could be closer on the horizon, a new study led by UNSW Sydney shows.
Last year, researchers at the University of California, Riverside, identified the early origins of neural crest cells -- embryonic cells in vertebrates that travel throughout the body and generate many cell types -- in chick embryos.
Researchers from Singapore-MIT Alliance for Research and Technology (SMART), MIT's research enterprise in Singapore, have developed a novel microcarrier for large-scale cell production and expansion that offers higher yield and cost-effectiveness compared to traditional methods, and reduces steps required in the cell retrieval process.