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Researchers Uncover Complex Substrate Profile for Enzyme Action

Research on γ-secretase reveals its unique substrate recognition mechanism, offering potential for developing precise therapeutic agents for various diseases.

14 Jul 2025

Understanding DNA's Complex 3D Architecture in the Cell

Investigating chromatin's 3D architecture reveals its influence on gene regulation, shedding light on mechanisms underlying cancer and muscular dystrophy.

14 Jul 2025

UAB Identifies Six Novel Subsets, Reshaping Immune Knowledge

The study highlights T-bet's importance in memory B cells, essential for rapid antibody production and sustained immune defense against influenza.

14 Jul 2025

Microglia Replacement Halts Progression of Fatal Neurological Disease in Mice and Humans

Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) is a progressive neurological disease with an average age of onset of 43 years and an average life expectancy of only 3 to 5 years after symptoms begin.

11 Jul 2025

SNAP-tag2 System Improves Protein Imaging with Faster, Brighter Labeling

SNAP-tag2 boosts live-cell imaging with faster labeling, brighter fluorescence, and better protein tracking across biological systems.

11 Jul 2025

Bacteria Show Unexpected Flexibility in Building Their Cell Walls

Closely related bacterial species use different strategies to build their cell walls, an international team of scientists led by Université de Montréal microbiology professor Yves Brun has found.

10 Jul 2025

Exercise Boosts Immune Response in Cancer Through Bacterial Metabolites

A new study from the University of Pittsburgh shows for the first time how exercise improves cancer outcomes and enhances response to immunotherapy in mice by reshaping the gut microbiome.

10 Jul 2025

Machine Learning Uncovers Hidden Role of Glial Cells

Long overlooked and underestimated, glial cells – non-neuronal cells that support, protect and communicate with neurons – are finally stepping into the neuroscience spotlight.

9 Jul 2025

Vanderbilt and Parse Biosciences Join Forces to Accelerate Measles Antibody Discovery

Vanderbilt University Medical Center and Parse Biosciences, an innovator in single-cell sequencing, are collaborating on a new treatment to help unvaccinated measles victims, as the U.S. measles outbreak has now reached its highest case count in 30 years.

9 Jul 2025

New Protein Superfamily Redefines Bacterial Interactions

A newly identified bacterial protein, PopA, reveals complex interactions in bacteria, challenging existing models of membrane protein formation.

9 Jul 2025

New Software Boosts Genome Editing Accuracy for Genetic Therapies

This innovative software, CRISPRware, optimizes guide RNA design for genome editing, supporting research on genetic disorders and uncharacterized peptides.

9 Jul 2025

New Insights into Cell Membrane Energy Waves

Johns Hopkins researchers identify energy-generating waves on cancer cell membranes, revealing potential targets for slowing tumor growth and spread.

9 Jul 2025

SPT Labtech and Semarion Collaborate to Advance Automated Cell-Based Assay Workflows

SPT Labtech, a global leader in innovative laboratory automation, today announced a strategic collaboration with Semarion, a University of Cambridge spin-out company from the Cavendish Laboratory combining materials engineering and cell biology to tackle unmet drug screening needs.

9 Jul 2025

Improved Bacterial Rubisco Offers Hope for Enhancing Plant Photosynthesis

During photosynthesis, an enzyme called rubisco catalyzes a key reaction - the incorporation of carbon dioxide into organic compounds to create sugars.

8 Jul 2025

New Global Platform Aims to Standardize and Improve Single-Cell Analysis

Researchers from more than 50 international institutions have launched Open Problems (https://openproblems.bio), a collaborative open-source platform to benchmark, improve, and run competitions for computational methods in single-cell genomics.

8 Jul 2025

Obesity-Related Cognitive Deficits Improved Through Astrocyte Modulation

Fatty diets and obesity affect the structure and function of astrocytes, the star-shaped brain cells located in the striatum, a brain region involved in the perception of pleasure generated by food consumption.

8 Jul 2025

Cryo-EM Uncovers How Tiny Protein Enzyme Precisely Trims tRNA

To build proteins, cells rely on a molecule called transfer RNA, or tRNA. tRNAs act like protein-building couriers, where they read the genetic instructions from messenger RNA, mRNA, and deliver the right amino acids to ribosomes, the cell's protein-making factories.

8 Jul 2025